ID   UN119_CAEBR             Reviewed;         217 AA.
AC   Q17297; A8XSC6; Q60YD0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Protein unc-119;
DE   AltName: Full=Uncoordinated protein 119;
GN   Name=unc-119; ORFNames=CBG18291;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8996090; DOI=10.1016/s0378-1119(96)00491-x;
RA   Maduro M.F., Pilgrim D.B.;
RT   "Conservation of function and expression of unc-119 from two Caenorhabditis
RT   species despite divergence of non-coding DNA.";
RL   Gene 183:77-85(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Myristoyl-binding protein that acts as a cargo adapter:
CC       specifically binds the myristoyl moiety of a subset of N-terminally
CC       myristoylated proteins and is required for their localization. Plays a
CC       key role in ciliary membrane localization of proteins. Required for the
CC       establishment or function of the nervous system (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: Adopts an immunoglobulin-like beta-sandwich fold forming a
CC       hydrophobic cavity that capture N-terminally myristoylated target
CC       peptides. Phe residues within the hydrophobic beta sandwich are
CC       required for myristate binding (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDE6D/unc-119 family. {ECO:0000305}.
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DR   EMBL; U45326; AAB41283.1; -; Genomic_DNA.
DR   EMBL; HE600936; CAP35768.1; -; Genomic_DNA.
DR   PIR; JC5728; JC5728.
DR   RefSeq; XP_002642299.1; XM_002642253.1.
DR   AlphaFoldDB; Q17297; -.
DR   STRING; 6238.CBG18291; -.
DR   EnsemblMetazoa; CBG18291a.1; CBG18291a.1; WBGene00037738.
DR   EnsemblMetazoa; CBG18291a.2; CBG18291a.2; WBGene00037738.
DR   GeneID; 8584293; -.
DR   KEGG; cbr:CBG_18291; -.
DR   CTD; 8584293; -.
DR   WormBase; CBG18291a; CBP04305; WBGene00037738; Cbr-unc-119.
DR   eggNOG; KOG4037; Eukaryota.
DR   HOGENOM; CLU_088825_0_0_1; -.
DR   InParanoid; Q17297; -.
DR   OMA; IAKPPHC; -.
DR   OrthoDB; 1270912at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0042953; P:lipoprotein transport; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   Gene3D; 2.70.50.40; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR008015; PDED_dom.
DR   InterPro; IPR037036; PDED_dom_sf.
DR   Pfam; PF05351; GMP_PDE_delta; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Developmental protein; Lipid-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..217
FT                   /note="Protein unc-119"
FT                   /id="PRO_0000221215"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         110
FT                   /ligand="tetradecanoate"
FT                   /ligand_id="ChEBI:CHEBI:30807"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        147
FT                   /note="K -> F (in Ref. 1; AAB41283)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  25075 MW;  73C1E7809568B09D CRC64;
     MKAEQQQSIP PGSATFPSQM PRPPPSTEQG ITTESELAKK AQITPNDVLA LPGITQGFLC
     SPSANIYNIE FTKFQIRDLD TEQVLFEIAK PENDQENDES PQESARYVRY RFAPNFLKLK
     TVGATVEFKV GDIPIHHFRM IERHFFKDRL LKCFDFEFGF CIPNSRNNCE HIYEFPQLSQ
     QLMDDMINNP NETRSDSFYF VDNKLVMHNK ADYSYDA