UN119_DROME
ID UN119_DROME Reviewed; 265 AA.
AC Q9XYQ2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein unc-119 homolog;
DE Short=DmUNC-119;
GN Name=unc-119; ORFNames=CG1659;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10858820; DOI=10.3109/01677060009084494;
RA Maduro M.F., Gordon M., Jacobs R., Pilgrim D.B.;
RT "The UNC-119 family of neural proteins is functionally conserved between
RT humans, Drosophila and C. elegans.";
RL J. Neurogenet. 13:191-212(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Myristoyl-binding protein that acts as a cargo adapter:
CC specifically binds the myristoyl moiety of a subset of N-terminally
CC myristoylated proteins and is required for their localization.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in nervous system.
CC -!- DOMAIN: Adopts an immunoglobulin-like beta-sandwich fold forming a
CC hydrophobic cavity that capture N-terminally myristoylated target
CC peptides. Phe residues within the hydrophobic beta sandwich are
CC required for myristate binding (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDE6D/unc-119 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF119102; AAD30967.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46250.1; -; Genomic_DNA.
DR RefSeq; NP_001284978.1; NM_001298049.1.
DR RefSeq; NP_572389.1; NM_132161.5.
DR AlphaFoldDB; Q9XYQ2; -.
DR SMR; Q9XYQ2; -.
DR BioGRID; 58140; 9.
DR DIP; DIP-22008N; -.
DR IntAct; Q9XYQ2; 2.
DR STRING; 7227.FBpp0071024; -.
DR PaxDb; Q9XYQ2; -.
DR DNASU; 31664; -.
DR EnsemblMetazoa; FBtr0071066; FBpp0071024; FBgn0025549.
DR EnsemblMetazoa; FBtr0346619; FBpp0312199; FBgn0025549.
DR GeneID; 31664; -.
DR KEGG; dme:Dmel_CG1659; -.
DR CTD; 31664; -.
DR FlyBase; FBgn0025549; unc-119.
DR VEuPathDB; VectorBase:FBgn0025549; -.
DR eggNOG; KOG4037; Eukaryota.
DR GeneTree; ENSGT00390000014595; -.
DR HOGENOM; CLU_088825_2_0_1; -.
DR InParanoid; Q9XYQ2; -.
DR OMA; CNSADMG; -.
DR OrthoDB; 1270912at2759; -.
DR PhylomeDB; Q9XYQ2; -.
DR BioGRID-ORCS; 31664; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31664; -.
DR PRO; PR:Q9XYQ2; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0025549; Expressed in egg cell and 32 other tissues.
DR ExpressionAtlas; Q9XYQ2; baseline and differential.
DR Genevisible; Q9XYQ2; DM.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0042953; P:lipoprotein transport; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IGI:FlyBase.
DR Gene3D; 2.70.50.40; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008015; PDED_dom.
DR InterPro; IPR037036; PDED_dom_sf.
DR InterPro; IPR032977; UNC119_homologue_A.
DR PANTHER; PTHR12951:SF5; PTHR12951:SF5; 1.
DR Pfam; PF05351; GMP_PDE_delta; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Lipid-binding; Protein transport; Reference proteome; Transport.
FT CHAIN 1..265
FT /note="Protein unc-119 homolog"
FT /id="PRO_0000221217"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 154
FT /ligand="tetradecanoate"
FT /ligand_id="ChEBI:CHEBI:30807"
FT /evidence="ECO:0000250"
SQ SEQUENCE 265 AA; 28412 MW; 6C183CBCF5F2B95E CRC64;
MSVVGKQLNP VQSSGAGAVT TSSSAAAGSS SSNSGVEANG GSGGSSGAAA AGAGASGDAK
RPAESSSVTP DEVLHLTKIT DDYLCSANAN VFEIDFTRFK IRDLESGAVL FEIAKPPSEQ
YPEGLSSDET MLAAAEKLSL DDTADPNAGR YVRYQFTPAF LNLKTVGATV EFTVGSQPLN
NFRMIERHFF RDRLLKTFDF EFGFCFPFSK NTVEHIYEFP NLPPDLVAEM ISSPFETRSD
SFYFVGNRLV MHNKADYAYD GGNIV
