ID   CA1A_CONMA              Reviewed;          15 AA.
AC   P0C1W1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   23-FEB-2022, entry version 36.
DE   RecName: Full=Alpha-conotoxin-like MIA;
OS   Conus magus (Magical cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6492;
RN   [1]
RP   REVIEW, AND AMIDATION AT CYS-15.
RX   PubMed=12114524; DOI=10.1074/jbc.m205102200;
RA   McIntosh J.M., Dowell C., Watkins M., Garrett J.E., Yoshikami D.,
RA   Olivera B.M.;
RT   "Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of
RT   nicotinic acetylcholine receptors.";
RL   J. Biol. Chem. 277:33610-33615(2002).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha3/5 pattern.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   ConoServer; 14; M1A.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..15
FT                   /note="Alpha-conotoxin-like MIA"
FT                   /id="PRO_0000249788"
FT   MOD_RES         15
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:12114524"
FT   DISULFID        4..9
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
FT   DISULFID        5..15
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
SQ   SEQUENCE   15 AA;  1662 MW;  DEFF731C2BF011E9 CRC64;
     DGRCCHPACA KHFNC