ID   UN45A_PONAB             Reviewed;         929 AA.
AC   Q5RAP0;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein unc-45 homolog A;
DE            Short=Unc-45A;
DE   AltName: Full=Smooth muscle cell-associated protein 1;
DE            Short=SMAP-1;
GN   Name=UNC45A; Synonyms=SMAP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as co-chaperone for HSP90 (Potential). Prevents the
CC       stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in
CC       promoting PGR function in the cell (By similarity). May be necessary
CC       for proper folding of myosin (Potential). Necessary for normal cell
CC       proliferation. Necessary for normal myotube formation and myosin
CC       accumulation during muscle cell development. May play a role in
CC       erythropoiesis in stroma cells in the spleen (By similarity).
CC       {ECO:0000250, ECO:0000305}.
CC   -!- SUBUNIT: Interacts with PGR isoforms A and B as well as with NR3C1 in
CC       the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves
CC       2 UNC45A monomers per HSP90AB1 dimer (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominant in the
CC       perinuclear region. Little protein in the nucleus (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; CR858975; CAH91170.1; -; mRNA.
DR   RefSeq; NP_001127383.1; NM_001133911.1.
DR   AlphaFoldDB; Q5RAP0; -.
DR   BMRB; Q5RAP0; -.
DR   SMR; Q5RAP0; -.
DR   STRING; 9601.ENSPPYP00000007701; -.
DR   PRIDE; Q5RAP0; -.
DR   GeneID; 100174449; -.
DR   KEGG; pon:100174449; -.
DR   CTD; 55898; -.
DR   eggNOG; KOG4151; Eukaryota.
DR   InParanoid; Q5RAP0; -.
DR   OrthoDB; 1059433at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR024660; UCS_central_dom.
DR   Pfam; PF13181; TPR_8; 1.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Cytoplasm; Developmental protein; Differentiation;
KW   Myogenesis; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..929
FT                   /note="Protein unc-45 homolog A"
FT                   /id="PRO_0000249890"
FT   REPEAT          6..39
FT                   /note="TPR 1"
FT   REPEAT          43..76
FT                   /note="TPR 2"
FT   REPEAT          77..110
FT                   /note="TPR 3"
FT   MOD_RES         55
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3U1"
FT   MOD_RES         468
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3U1"
SQ   SEQUENCE   929 AA;  101757 MW;  C72A45413A185C69 CRC64;
     MTASSVEQLR KEGNELFKCG DYGGALAAYT QALGLDATPQ DQAVLHRNRA ACYLKLEDYD
     KAETEASKAI EKDGGDVKAL YRRSQALEKL GRLDQAVLDL QRCVSLEPKN KVFQEALRNI
     GGQIQEKVRY MSSTDAKVEQ MFQILLDPEE KGTEKKQKAS QNLVVLARED AGAEKTLRSN
     GVQLLQRLLD TGETDLMLAA LRTLVGICSE HQSRTVATLS ILGTRRVVSI LGVESQSVSL
     AACHLLQVMF DALKEGVKKG FRGKEGAIIV DPARELKVLI SNLLDLLTEV GVSGQGRDNA
     LTLLIKAVPR KSLKDPNNSL TLWVIDQGLK KILEVGGSLQ DPPGELAVTA NSRMSASILL
     SKLFDDLKCD AERENFHRLC ENYIKSWFEG RGLAGKLRAI QTVSCLLQGP CDAGNRALEL
     SGVMEGVIAL CASEQEEEQL VAVEALIHAA GKAKRASFIT ANGVSLLKDL YKRSEKDSIR
     IRALVGLCKL GSAGGTDFSM KQFAEGSTLK LAKQCRKWLC NDQIDAGTRR WAVEGLAYLT
     FDADVKEEFV EDAAALKALF QLSRSEERSV LFAVASALVN CTNSYDYEEP DPKMVELAKY
     AKQHVPEQHP KDKPSFVRAR VKKLLAAGVV SAMVYMVKTE SPVLTSSCRE LLSRIFLALV
     EEVEDRGTVV AQGGGRALIP LALEGTDVGQ TKAAQALAKL TITSNPEMTF PGERIYEVVR
     PLVSLLHLNC SGLQNFEALM ALTNLAGISE RLRQKILKEK AVPMIEGYMF EEHEMIRRAS
     TECMCNLAMS KEVQDLFEAE GNDRLKLLVL YSGEDDELLQ RAAAGGLAML TSMRPTLCSR
     IPQVTTHWLE ILQALLLSSN QELQHRGAVV VLNMVEASRE IASTLMESEM MEILSVLAKG
     DHSPVTRAAA ACLDKAVEYG LIQPNQDGE