ID   UN45B_XENLA             Reviewed;         927 AA.
AC   Q68F64;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein unc-45 homolog B {ECO:0000250|UniProtKB:Q8CGY6};
DE            Short=Unc-45B {ECO:0000250|UniProtKB:Q8CGY6};
GN   Name=unc45b {ECO:0000312|Xenbase:XB-GENE-971733};
GN   Synonyms=cmya4 {ECO:0000250|UniProtKB:Q8CGY6};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH79980.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH79980.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a co-chaperone for HSP90 and is required for proper
CC       folding of the myosin motor domain. Plays a role in sarcomere formation
CC       during muscle cell assembly (By similarity). Is necessary for normal
CC       early lens development. {ECO:0000250|UniProtKB:D7REX8,
CC       ECO:0000250|UniProtKB:Q6DGE9, ECO:0000250|UniProtKB:Q8CGY6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band
CC       {ECO:0000250|UniProtKB:Q8IWX7}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the
CC       perinuclear region of myofibrils. Translocates to the A band in
CC       response to stress conditions and fibril damage.
CC       {ECO:0000250|UniProtKB:Q6DGE9}.
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DR   EMBL; BC079980; AAH79980.1; -; mRNA.
DR   RefSeq; NP_001087472.1; NM_001094003.1.
DR   AlphaFoldDB; Q68F64; -.
DR   SMR; Q68F64; -.
DR   MaxQB; Q68F64; -.
DR   DNASU; 447296; -.
DR   GeneID; 447296; -.
DR   KEGG; xla:447296; -.
DR   CTD; 447296; -.
DR   Xenbase; XB-GENE-971733; unc45b.S.
DR   OMA; CDPERAN; -.
DR   OrthoDB; 1059433at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 447296; Expressed in muscle tissue and 9 other tissues.
DR   GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0002088; P:lens development in camera-type eye; ISS:UniProtKB.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR024660; UCS_central_dom.
DR   Pfam; PF13181; TPR_8; 1.
DR   Pfam; PF11701; UNC45-central; 1.
DR   SMART; SM00185; ARM; 5.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Developmental protein; Differentiation; Myogenesis;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..927
FT                   /note="Protein unc-45 homolog B"
FT                   /id="PRO_0000410948"
FT   REPEAT          4..37
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          41..74
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          76..108
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          167..206
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          209..248
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          746..785
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   927 AA;  103510 MW;  42837E57F4C2C540 CRC64;
     MEDPVQLKEE GNKYFQSNDY GNAIECYSKA LKLITDKKMK AVLYRNRSAC YLKQENYIQA
     AADASKAIDV DASDIKALFR RCQALEKLGK LDQAYKDVQR CATLEPKNRT FLEMLHRLGS
     NIQEKLHVQF STDSRVQKMF EILLDENSDK EKREKAANNL IVLGREDAGA ERIFQNNGVN
     LLMQLIETKD PELILSAVRT LSGMCTGHRA RATAIVHLVG INKICSIMAV DHEEIALAAC
     NLLQNIVDSL TGEDKKVHGK EEALVLDTKK DLKVITTHLL DMLVSKKVSG HGRDQALNLL
     NKNIPRYDLK NKDNSKTLFV VDVGLKKILK VLGQVPELPN CLPLTPNTRL NASVLINKLY
     DDLRCDPERD DFRKICEEYI TGSFDPKDME KNLHAIQTVS GILQGPFDLG NILLGMQGVM
     EMMVALTGSE KEVDQLVAVE ALIHASTKLS RASFIITNGV SLLKDIYKKT KNEKIKIRAL
     VGLCKLGSAG GTDYALRQFA EGSTDKLAKQ CRKWLCNTSL DIQTRKWAVE GLAYLTLDAD
     VKDEFVEDEQ SLKAMFELCK TSDKTILYSV ATTLVNCTNS YDVKEVIPEM VQLAKFSKQH
     VPEQHPKDKK DFVLKRVKKL LQADVISALS CMVKADNSIL TDQTKEQIAR VFLALCDEPK
     DRGIIVAQGG GKAMIPLALE GTDVGKTKAS HGLAKIAAVS NPDIAFPGER VYEVVRPLVS
     LLNTERDGVQ NFEALLALTN LSGKSDKLRQ KIVKEKALPE IENYMFENHE QIRQAATECM
     CNLAVNKEVK ERFTAEGNDR LKLIVLLCGE DEEVKLQRAA AGTLAILTAA EKKLCHKMTE
     VTSQWLEILQ RLCLNEDLQV QHRGVVITYN LISAEKELAK KLVESEMLEI LTVIGKQADV
     PNKQHIINVA REALVKCLDY GFIKTVS