ID   UN50A_XENLA             Reviewed;         259 AA.
AC   Q6DKM1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Protein unc-50 homolog A;
GN   Name=unc50-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the cell surface expression of neuronal nicotinic
CC       receptors (By similarity). Binds RNA (By similarity).
CC       {ECO:0000250|UniProtKB:O55227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:O55227}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O55227}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q53HI1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q53HI1}.
CC   -!- SIMILARITY: Belongs to the unc-50 family. {ECO:0000305}.
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DR   EMBL; BC071145; AAH71145.1; -; mRNA.
DR   RefSeq; NP_001085372.1; NM_001091903.1.
DR   AlphaFoldDB; Q6DKM1; -.
DR   DNASU; 443798; -.
DR   GeneID; 443798; -.
DR   KEGG; xla:443798; -.
DR   CTD; 443798; -.
DR   Xenbase; XB-GENE-1005838; unc50.L.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 443798; Expressed in liver and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR   InterPro; IPR007881; UNC-50.
DR   PANTHER; PTHR12841; PTHR12841; 1.
DR   Pfam; PF05216; UNC-50; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Nucleus; Reference proteome; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..259
FT                   /note="Protein unc-50 homolog A"
FT                   /id="PRO_0000308965"
FT   TOPO_DOM        1..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..112
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..181
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        203..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..259
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  30602 MW;  D5F3C6852F581157 CRC64;
     MLPTTSVSPR SPDNGILSPR EAARHTAGAK RYKYLRRLFH FKQMDFEFAL WQMLYLFTSP
     QKVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTVGFG FVLDMSFFET FKLLLWVVFI
     DCVGVGLLIA TLMWFVSNKY MVKRQGKDYD VEWGYTFDVH LNAFYPLLVI LHFIQLFFIN
     HVILSGWFIG YFVGNTIWLI AIGYYIYITF LGYSALPFLK NTVILLYPFA ALALLYVLSL
     ALGWNFTEKL CLFYKYRVR