ID   UN50B_XENLA             Reviewed;         259 AA.
AC   Q5U520;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Protein unc-50 homolog B;
GN   Name=unc50-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the cell surface expression of neuronal nicotinic
CC       receptors (By similarity). Binds RNA (By similarity).
CC       {ECO:0000250|UniProtKB:O55227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:O55227}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O55227}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q53HI1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q53HI1}.
CC   -!- SIMILARITY: Belongs to the unc-50 family. {ECO:0000305}.
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DR   EMBL; BC084865; AAH84865.1; -; mRNA.
DR   RefSeq; NP_001088522.1; NM_001095053.2.
DR   RefSeq; XP_018103913.1; XM_018248424.1.
DR   AlphaFoldDB; Q5U520; -.
DR   DNASU; 495394; -.
DR   GeneID; 495394; -.
DR   KEGG; xla:495394; -.
DR   CTD; 495394; -.
DR   Xenbase; XB-GENE-6253952; unc50.S.
DR   OMA; IWFISNK; -.
DR   OrthoDB; 1351297at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 495394; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR   InterPro; IPR007881; UNC-50.
DR   PANTHER; PTHR12841; PTHR12841; 1.
DR   Pfam; PF05216; UNC-50; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Nucleus; Reference proteome; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..259
FT                   /note="Protein unc-50 homolog B"
FT                   /id="PRO_0000308966"
FT   TOPO_DOM        1..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..109
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..181
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        203..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..259
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  30417 MW;  350DC453F4F47768 CRC64;
     MLPTTSVSPR SPDNGILSPR DATRHTAGAK RYKYLRRLFH FKQMDFEFAL WQMLYLFTSP
     QKVYRNFHYR KQTKDQWARD DPAFLVLLGI WLCVSTVGFG FVLDMSFFET FTLLLWVVFI
     DCVGVGLLIA TSMWFVSNKY MVNRQGKDYD VEWGYTFDVH LNAFYPLLVI LHFIQLFFIN
     HVILTGWFIG CFVGNTLWLI AIGYYIYITF LGYSALPFLK NTVVLLYPFA ALALLYILSL
     ALGWNFTAKL CLFYKYRVR