UN5BA_XENLA
ID UN5BA_XENLA Reviewed; 943 AA.
AC Q8JGT4;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Netrin receptor UNC5B-a;
DE AltName: Full=Protein Xunc-5;
DE AltName: Full=Protein unc-5 homolog-a;
DE Flags: Precursor;
GN Name=unc5b-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12351179; DOI=10.1016/s0925-4773(02)00215-0;
RA Anderson R.B., Holt C.E.;
RT "Expression of UNC-5 in the developing Xenopus visual system.";
RL Mech. Dev. 118:157-160(2002).
CC -!- FUNCTION: Plays a role in cell-cell adhesion during embryonic
CC development. Receptor for netrin required for axon guidance. Mediates
CC axon repulsion of neuronal growth cones in the developing nervous
CC system upon ligand binding (By similarity).
CC {ECO:0000250|UniProtKB:C5IAW9, ECO:0000250|UniProtKB:O08722}.
CC -!- SUBUNIT: Interacts (via extracellular domain) with flrt3 (via
CC extracellular domain). Interacts with rnd1.
CC {ECO:0000250|UniProtKB:C5IAW9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:C5IAW9};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: In the developing visual system, it is expressed
CC within the developing optic vesicles and later become restricted to the
CC dorsal ciliary marginal zone, a site of retinoblast proliferation and
CC differentiation. {ECO:0000269|PubMed:12351179}.
CC -!- PTM: Phosphorylated on cytoplasmic tyrosine residues. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the unc-5 family. {ECO:0000305}.
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DR EMBL; AY099459; AAM34486.1; -; mRNA.
DR RefSeq; NP_001082302.1; NM_001088833.1.
DR AlphaFoldDB; Q8JGT4; -.
DR SMR; Q8JGT4; -.
DR PRIDE; Q8JGT4; -.
DR GeneID; 398393; -.
DR KEGG; xla:398393; -.
DR CTD; 398393; -.
DR Xenbase; XB-GENE-6046969; unc5b.L.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 398393; Expressed in egg cell and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 2.20.100.10; -; 2.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; PTHR12582; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF82895; SSF82895; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..943
FT /note="Netrin receptor UNC5B-a"
FT /id="PRO_0000036074"
FT TOPO_DOM 31..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..943
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 51..148
FT /note="Ig-like"
FT DOMAIN 150..245
FT /note="Ig-like C2-type"
FT DOMAIN 249..303
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 305..357
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 542..685
FT /note="ZU5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT DOMAIN 863..941
FT /note="Death"
FT REGION 688..836
FT /note="UPA domain"
FT /evidence="ECO:0000250"
FT CARBOHYD 225
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 72..133
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 84..131
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 177..228
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 261..298
FT /evidence="ECO:0000250"
FT DISULFID 265..302
FT /evidence="ECO:0000250"
FT DISULFID 276..288
FT /evidence="ECO:0000250"
FT DISULFID 317..351
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 321..356
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 329..341
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
SQ SEQUENCE 943 AA; 105084 MW; A024E24A7EDB6175 CRC64;
MYLSRNPSGA ALAAILVALI LSCNFPSSTA GIEYSDVLPD SFPSAPAESL PHFLLEPEDA
YIVKNKPVEL VCKANPATQI YFKCNGEWVN QNDHITKERV DDVTGLVVRE VQIEVSRQQV
EELFGLEDYW CQCVAWSSAG TTKSKRSYVR IAYLRKNFDQ EPLGKEVALE QEALLQCRPP
EGVPPAEVEW LKNEEIIDPT KDTNFLITID HNLIIKQARL SDTANYTCVS KNIVAKRRST
TATVIVFVNG GWSSWTEWSP CNNRCGHGWQ KRTRTCTNPA PLNGGTMCEG QQYQKFACNT
MCPVDGGWTE WSKWSACSTE CTHWRSRECN APTPKNGGKD CSGMLLDSKN CTDGLCMQNK
RVLGETKSRL LESTGDVALY AGLVVAIFIV IILLMAVGIV VYRRNCREFD TDITDSSAAL
TGGFHPVNFK TSRHDNSQLI HPAMQPDLTA NAGIYRGNMY ALQDSADKIP MTNSPLLDPL
PNLKIKVYNS STVGSSPGIH DGNNLLGTKP TGTYPSDNNI MNARNKNMSM QHLLTLPRDS
SNSVTGTFGS LGGRLTFPNT GVSLLIPQGA IPQGKYYEMY LMINKRENTV LPSEGTQTIL
SPIITCGPTG LLLCKPVILT VPHCADINTS DWILQLKTQS HQGNWEEVVT LNEETLNTPC
YCQLESHSCH TLLDQLGTYA FVGESYSRSA IKRLQLAIFA PMLCTSLEYN LKVYCVEDTP
DALKEVLELE KTLGGYLVEE PKLLMFKDSY HNLRLSIHDI PHSLWRSKLM AKYQEIPFYH
IWSGSQRTLH CTFTLERYSL AATELTCKIC VRQVEGEGQI FQLHTLLEEN VKSFDPFCSQ
AENSVTTHLG PYAFKIPFSI RQKICNSLDA PNSRGNDWRL LAQKLCMDRY LNYFATKASP
TGVILDLWEA LHQDDGDLNT LASALEEMGK SEMMLVMATD GDC
