ID   UN5BB_XENLA             Reviewed;         942 AA.
AC   C5IAW9;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Netrin receptor UNC5B-b {ECO:0000305};
DE   AltName: Full=Protein unc-5 homolog-b;
DE   AltName: Full=Unc-5-like protein B {ECO:0000312|EMBL:ACR78433.1};
DE   Flags: Precursor;
GN   Name=unc5b-b {ECO:0000305};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000312|EMBL:ACR78433.1};
RN   [1] {ECO:0000312|EMBL:ACR78433.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FLRT3 AND RND1, SUBCELLULAR
RP   LOCATION, AND FUNCTION.
RX   PubMed=19492039; DOI=10.1371/journal.pone.0005742;
RA   Karaulanov E., Boettcher R.T., Stannek P., Wu W., Rau M., Ogata S.,
RA   Cho K.W.Y., Niehrs C.;
RT   "Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus
RT   embryos.";
RL   PLoS ONE 4:E5742-E5742(2009).
CC   -!- FUNCTION: Plays a role in cell-cell adhesion during embryonic
CC       development (PubMed:19492039). Receptor for netrin required for axon
CC       guidance. Mediates axon repulsion of neuronal growth cones in the
CC       developing nervous system upon ligand binding (By similarity).
CC       {ECO:0000250|UniProtKB:O08722, ECO:0000269|PubMed:19492039}.
CC   -!- SUBUNIT: Interacts (via extracellular domain) with flrt3 (via
CC       extracellular domain). Interacts with rnd1.
CC       {ECO:0000269|PubMed:19492039}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19492039};
CC       Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the unc-5 family. {ECO:0000305}.
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DR   EMBL; FJ824811; ACR78433.1; -; mRNA.
DR   RefSeq; NP_001155366.1; NM_001161894.1.
DR   AlphaFoldDB; C5IAW9; -.
DR   SMR; C5IAW9; -.
DR   GeneID; 100302095; -.
DR   KEGG; xla:100302095; -.
DR   CTD; 100302095; -.
DR   Xenbase; XB-GENE-17333473; unc5b.S.
DR   OrthoDB; 334938at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 100302095; Expressed in egg cell and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   CDD; cd08802; Death_UNC5B; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 2.20.100.10; -; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR042156; Death_UNC5B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; PTHR12582; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF82895; SSF82895; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Developmental protein; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..942
FT                   /note="Netrin receptor UNC5B-b"
FT                   /id="PRO_0000434571"
FT   TOPO_DOM        31..380
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        402..942
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          51..148
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DOMAIN          150..245
FT                   /note="Ig-like C2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DOMAIN          249..303
FT                   /note="TSP type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          305..357
FT                   /note="TSP type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          541..684
FT                   /note="ZU5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT   DOMAIN          863..940
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   REGION          687..835
FT                   /note="UPA domain"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        225
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   DISULFID        72..133
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT   DISULFID        84..131
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT   DISULFID        177..228
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44,
FT                   ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        261..298
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        265..302
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        276..288
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DISULFID        317..351
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT   DISULFID        321..356
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT   DISULFID        329..341
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZN44"
SQ   SEQUENCE   942 AA;  104842 MW;  D1369FE28407255F CRC64;
     MYLSRIPGGA ALAALLVALL LCCNFPPSIA GIEYSDVLPD SFPSAPAESL PHFLLEPEDA
     YIVKNKAVEL VCKANPATQI YFKCNGEWVN QNDHITKERV DDVTGLVVRE VQIEVSRQQV
     EELFGLEDFW CQCVAWSSAG TTKSKRSYVR IAYLRKNFDQ EPLGKEVALE QEALLQCRPP
     EGVPPAEVEW LKNEEIIDST KDTNFLITID HNLIIKQARL SDTANYTCVA KNIVAKRRST
     TATVIVFVNG GWSSWTEWSP CNNRCGHGWQ KRTRTCTNPA PLNGGTMCEG QQYQKFACNT
     MCPVDGGWTE WSKWSACSTE CTHWRSRECN APTPKNGGKD CSGMLLDSKN CTDGLCMQNK
     RVLGETKSHL LESTGDVALY AGLVVAIFII IILLMAVGIV VYRRNCREFD TDITDSSAAL
     TGGFHPVNFK TSRHDNSHLI HPAMQPDLTA NAGIYRGHMY ALQDSADKIP MTNSPLLDPL
     PNLKIKVYNS STVGSSPGIH DGNDLLGAKP TGTYPSDNIM NARNKNMSTQ HLLTLPRDSS
     NSVTGTFGSL GGRLTFPNTG VSLLIPQGAI PQGKYYEMYL MINKRENTVL PSEGTQTILS
     PIITCGPTGL LLCKPVILTV PHCADITTSD WILQLKTQSH QGNWEEVVTL NEETLNTPCY
     CQLESHSCHI LLDQLGTYAF VGESYSRSAI KRLQLAIFAP MLCTSLEYNL KVYCVEDTPD
     ALKEVLELEK TLGGYLIEEP KPLMFKDSYH NLRLSIHDIP HSLWRSKLLA KYQEIPFYHV
     WSGSQRTLHC TFTLERYSLA ATELTCKICV RQVEGEGQIF QLHTSLEENV KSFDPFCSHA
     ENSVTTQLGP YAFKIPFLIR QKICNSLDAP NSRGNDWRLL AQKLCMDRYL NYFATKASPT
     GVILDLWEAL HQDDGDLNTL ASALEEMGKS EMMLVMATDG DC