UN5CL_MOUSE
ID UN5CL_MOUSE Reviewed; 518 AA.
AC Q6R653; Q3UMF8; Q501N0; Q8BTQ8; Q8BYF7; Q8C1L0; Q8K3C8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=UNC5C-like protein;
DE AltName: Full=Protein unc-5 homolog C-like;
DE AltName: Full=ZU5 and death domain-containing protein;
GN Name=Unc5cl; Synonyms=Zud;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=14769797; DOI=10.1074/jbc.m310737200;
RA Zhang J., Xu L.-G., Han K.-J., Shu H.-B.;
RT "Identification of a ZU5 and death domain-containing inhibitor of NF-
RT kappaB.";
RL J. Biol. Chem. 279:17819-17825(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Liver, Mammary gland, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N, and NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits NF-kappa-B-dependent transcription by impairing NF-
CC kappa-B binding to its targets. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with p65/RELA and NFKB1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6R653-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6R653-2; Sequence=VSP_029236, VSP_029237;
CC Name=3;
CC IsoId=Q6R653-3; Sequence=VSP_029236, VSP_029237, VSP_029239,
CC VSP_029240;
CC Name=4;
CC IsoId=Q6R653-4; Sequence=VSP_029235, VSP_029238;
CC -!- SIMILARITY: Belongs to the unc-5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE26140.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY510108; AAS80164.1; -; mRNA.
DR EMBL; AK010945; BAC25320.1; -; mRNA.
DR EMBL; AK039924; BAC30479.1; -; mRNA.
DR EMBL; AK089034; BAC40711.1; -; mRNA.
DR EMBL; AK144925; BAE26140.1; ALT_FRAME; mRNA.
DR EMBL; BC022701; AAH22701.1; -; mRNA.
DR EMBL; BC095959; AAH95959.1; -; mRNA.
DR CCDS; CCDS28870.1; -. [Q6R653-1]
DR AlphaFoldDB; Q6R653; -.
DR SMR; Q6R653; -.
DR STRING; 10090.ENSMUSP00000074159; -.
DR PhosphoSitePlus; Q6R653; -.
DR PaxDb; Q6R653; -.
DR PRIDE; Q6R653; -.
DR ProteomicsDB; 300087; -. [Q6R653-1]
DR ProteomicsDB; 300088; -. [Q6R653-2]
DR ProteomicsDB; 300090; -. [Q6R653-4]
DR UCSC; uc008cya.1; mouse. [Q6R653-2]
DR UCSC; uc008cyb.1; mouse. [Q6R653-4]
DR MGI; MGI:1923839; Unc5cl.
DR eggNOG; KOG1480; Eukaryota.
DR InParanoid; Q6R653; -.
DR PhylomeDB; Q6R653; -.
DR ChiTaRS; Unc5cl; mouse.
DR PRO; PR:Q6R653; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6R653; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; ISO:MGI.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:MGI.
DR GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; PTHR12582; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..518
FT /note="UNC5C-like protein"
FT /id="PRO_0000309568"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..518
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 102..237
FT /note="ZU5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT DOMAIN 415..494
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT REGION 186..400
FT /note="Interaction with RELA and NFKB1"
FT /evidence="ECO:0000250"
FT REGION 208..235
FT /note="Peptidase S68"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT ACT_SITE 227
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT ACT_SITE 229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT VAR_SEQ 1..354
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029235"
FT VAR_SEQ 1..342
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029236"
FT VAR_SEQ 343..373
FT /note="SFCFRRKAANGNEECSALTNEIIVTMHTFQD -> MWMIAVASWFHISTSGM
FT ESAPSVLSASGERQ (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029237"
FT VAR_SEQ 355..383
FT /note="EECSALTNEIIVTMHTFQDGLETKYVEIL -> MWMIAVASWFHISTSGMES
FT APSVLSASGE (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029238"
FT VAR_SEQ 446..449
FT /note="FLSC -> DPVD (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029239"
FT VAR_SEQ 450..518
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029240"
FT CONFLICT 46
FT /note="P -> L (in Ref. 1; AAS80164)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="G -> R (in Ref. 2; AAH95959)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="S -> L (in Ref. 2; AAH95959)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="F -> V (in Ref. 1; AAS80164)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 518 AA; 57956 MW; 9CDBC91527996C8B CRC64;
MSPQESSVQP SQFLLLVGIP VASALLLAQC LRWHCCQWLP GTCRKPDDPE EPVSPSTPLP
EYELPRQCPA PTLPEVAAFY QELHMPTQGQ TVTRQMMHKL LVFSAREVDH RGGCLILQDT
GISLLIPPGA VTVGRQERVS LVLVWDLTDA PSLSHRQGLV SPVVACGPHG ASFLKPCTLT
FKHCAQQPSQ ACAYSSNTSL LDAKDWKPLG QPGTHISRDE CRILLSHFSL YTCVLEAPLG
QTARKWLQLA MFCSPLVPGQ THLQLRVYFL NNTPCALQWA ITNEQPHGGR MRGPCQLFDF
TGARADQCLK LKYISEGWEN VDDSSSQLVP HLHIWHGKCP FRSFCFRRKA ANGNEECSAL
TNEIIVTMHT FQDGLETKYV EILRFQASEE ETWAVPPPVS QPPLCNRLPP ELFEQLQMLL
EPNSVTGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTSMER
LDCASAIQNY LNRSPRGSPD RLHGGTWENH GLELDEKL
