UN933_ARATH
ID UN933_ARATH Reviewed; 464 AA.
AC Q94AA1; B9DFQ8; Q67XL1; Q67Y57; Q9SF56;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=UNC93-like protein 3;
GN OrderedLocusNames=At3g09470; ORFNames=F11F8.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q94AA1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q94AA1-2; Sequence=VSP_014037, VSP_014038;
CC -!- SIMILARITY: Belongs to the unc-93 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF23279.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016661; AAF23279.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74771.1; -; Genomic_DNA.
DR EMBL; AY049250; AAK83592.1; -; mRNA.
DR EMBL; BT004735; AAO43565.1; -; mRNA.
DR EMBL; AK176494; BAD44257.1; -; mRNA.
DR EMBL; AK176611; BAD44374.1; -; mRNA.
DR EMBL; AK176808; BAD44571.1; -; mRNA.
DR EMBL; AK316867; BAH19575.1; -; mRNA.
DR RefSeq; NP_850546.1; NM_180215.4. [Q94AA1-2]
DR AlphaFoldDB; Q94AA1; -.
DR SMR; Q94AA1; -.
DR BioGRID; 5438; 1.
DR STRING; 3702.AT3G09470.1; -.
DR PaxDb; Q94AA1; -.
DR PeptideAtlas; Q94AA1; -.
DR PRIDE; Q94AA1; -.
DR ProteomicsDB; 245272; -. [Q94AA1-1]
DR EnsemblPlants; AT3G09470.2; AT3G09470.2; AT3G09470. [Q94AA1-2]
DR GeneID; 820104; -.
DR Gramene; AT3G09470.2; AT3G09470.2; AT3G09470. [Q94AA1-2]
DR KEGG; ath:AT3G09470; -.
DR Araport; AT3G09470; -.
DR TAIR; locus:2074929; AT3G09470.
DR eggNOG; KOG3097; Eukaryota.
DR HOGENOM; CLU_025356_1_1_1; -.
DR InParanoid; Q94AA1; -.
DR OMA; FLCLEYK; -.
DR PhylomeDB; Q94AA1; -.
DR PRO; PR:Q94AA1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q94AA1; baseline and differential.
DR Genevisible; Q94AA1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0055075; P:potassium ion homeostasis; IMP:TAIR.
DR CDD; cd17338; MFS_unc93_like; 1.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044771; UN933_plant.
DR PANTHER; PTHR19444:SF53; PTHR19444:SF53; 1.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..464
FT /note="UNC93-like protein 3"
FT /id="PRO_0000190043"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 415..437
FT /note="RDFTVEETHFTSSLLFQNSLSRN -> VCVSLFSFLFLALKVENVFTHDE
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640, ECO:0000303|Ref.4"
FT /id="VSP_014037"
FT VAR_SEQ 438..464
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640, ECO:0000303|Ref.4"
FT /id="VSP_014038"
FT CONFLICT 385
FT /note="K -> R (in Ref. 4; BAD44374)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 50292 MW; 31C0525F73B972A9 CRC64;
MESRNDEEAP LISASGEDRK VRAGKCYTRD VHILSISFLL IFLAYGAAQN LETTVNKDLG
TISLGILYVS FMFCSMVASL VVRLMGSKNA LVLGTTGYWL FVAANLKPSW FTMVPASLYL
GFAASIIWVG QGTYLTSIAR SHATDHGLHE GSVIGVFNGE FWAMFACHQL FGNLITLALL
KDGKEGSTSG TTLLMLVFLF SMTLGTILMF FIRKIDGEDG KGPVGSPVGL VDSLASLPRM
IITPLLDIRM LLIVPLLAYS GLQQAFVWAE FTKEIVTPAI GVSGVGGAMA VYGALDAVCS
MTAGRFTSGL SSITFIVSGG AVAQASVFLW LLLGYRQTSG VLGTAYPLIM AAILGIGDGI
LNTQISALLA LLFKHDTEGA FAQLKVWQSA AIAIVFFLSP YISLQAMLIV MLVMRDFTVE
ETHFTSSLLF QNSLSRNSLR FRRCLTIKIW DSLPISWESS FSYW