UN93L_DROME
ID UN93L_DROME Reviewed; 538 AA.
AC Q9Y115; Q0KHR6; Q6BD02;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=UNC93-like protein;
GN ORFNames=CG4928;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-523.
RX PubMed=15579698; DOI=10.1534/genetics.104.030478;
RA Swanson W.J., Wong A., Wolfner M.F., Aquadro C.F.;
RT "Evolutionary expressed sequence tag analysis of Drosophila female
RT reproductive tracts identifies genes subjected to positive selection.";
RL Genetics 168:1457-1465(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the unc-93 family. {ECO:0000305}.
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DR EMBL; AE014298; AAN09429.1; -; Genomic_DNA.
DR EMBL; AF145657; AAD38632.1; -; mRNA.
DR EMBL; AY665384; AAT76551.1; -; mRNA.
DR RefSeq; NP_573179.1; NM_132951.3.
DR RefSeq; NP_728035.1; NM_167552.2.
DR AlphaFoldDB; Q9Y115; -.
DR SMR; Q9Y115; -.
DR STRING; 7227.FBpp0074118; -.
DR GlyGen; Q9Y115; 2 sites.
DR PaxDb; Q9Y115; -.
DR DNASU; 32682; -.
DR EnsemblMetazoa; FBtr0074344; FBpp0074118; FBgn0027556.
DR EnsemblMetazoa; FBtr0074345; FBpp0074119; FBgn0027556.
DR GeneID; 32682; -.
DR KEGG; dme:Dmel_CG4928; -.
DR UCSC; CG4928-RA; d. melanogaster.
DR FlyBase; FBgn0027556; CG4928.
DR VEuPathDB; VectorBase:FBgn0027556; -.
DR eggNOG; KOG3097; Eukaryota.
DR GeneTree; ENSGT00530000063359; -.
DR HOGENOM; CLU_025356_1_0_1; -.
DR InParanoid; Q9Y115; -.
DR OrthoDB; 1145833at2759; -.
DR PhylomeDB; Q9Y115; -.
DR BioGRID-ORCS; 32682; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG4928; fly.
DR GenomeRNAi; 32682; -.
DR PRO; PR:Q9Y115; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0027556; Expressed in adult hindgut (Drosophila) and 23 other tissues.
DR ExpressionAtlas; Q9Y115; baseline and differential.
DR Genevisible; Q9Y115; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0055120; C:striated muscle dense body; IBA:GO_Central.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0006937; P:regulation of muscle contraction; IBA:GO_Central.
DR GO; GO:0043266; P:regulation of potassium ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..538
FT /note="UNC93-like protein"
FT /id="PRO_0000190042"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 538 AA; 58683 MW; B6C07AB5E7876EC9 CRC64;
MTGFTNAGFE NDEPVKPKAG FEPDTASLRE KVVLNPGEKW RILKNISIIS IAFMVQFTAF
QGTANLQSSI NAKDGLGTVS LSAIYAALVV SCIFLPTLII RKLTVKWTLV CSMLCYAPYI
AFQLFPRFYT LVPAGILVGM GAAPMWASKA TYLTQVGQVY AKITEQAVDA IIVRFFGFFF
LAWQSAELWG NLISSLVLSS GAHGGGSSSN TTVSEEDLQF CGANFCTTGS GGHGNLERPP
EDEIFEISMI YLSCIVAAVC IIAFFLDPLK RYGEKRKGSN SAAELSGLQL LSATFRQMKK
PNLQLLIPIT VFIGMEQAFI GADFTQAYVA CALGVNKIGF VMICFGVVNA LCSILFGSVM
KYIGRTPIIV LGAVVHFTLI TVELFWRPNP DNPIIFYAMS GLWGVGDAVW QTQINGLYGL
LFRRNKEAAF SNYRLWESAG FVIAYAYATT LCTQMKLYIL LAVLTLGCIG YVIVEILYRK
KQRKLKKQEK LEAAEKEKEA AAAAAAAALA AAEAGADGVE ETDDELDDLE EDIVVTRL
