ID   UNC1_CAEEL              Reviewed;         285 AA.
AC   Q21190;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protein unc-1;
DE   AltName: Full=Uncoordinated protein 1;
GN   Name=unc-1; ORFNames=K03E6.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SUBCELLULAR LOCATION, AND MUTAGENESIS OF GLU-184.
RX   PubMed=27015090; DOI=10.1371/journal.pgen.1005948;
RA   Meng L., Chen C.H., Yan D.;
RT   "Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP
RT   through VAB-8 in C. elegans Neurons.";
RL   PLoS Genet. 12:E1005948-E1005948(2016).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}. Cell junction, gap junction
CC       {ECO:0000269|PubMed:27015090}. Note=Co-localizes with unc-9 at the gap
CC       junctions formed between PLM and other neurons.
CC       {ECO:0000269|PubMed:27015090}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000305}.
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DR   EMBL; BX284606; CCD62863.1; -; Genomic_DNA.
DR   PIR; T34324; T34324.
DR   RefSeq; NP_508202.1; NM_075801.3.
DR   AlphaFoldDB; Q21190; -.
DR   SMR; Q21190; -.
DR   BioGRID; 45411; 2.
DR   STRING; 6239.K03E6.5b; -.
DR   EPD; Q21190; -.
DR   PaxDb; Q21190; -.
DR   EnsemblMetazoa; K03E6.5a.1; K03E6.5a.1; WBGene00006741.
DR   GeneID; 180458; -.
DR   KEGG; cel:CELE_K03E6.5; -.
DR   UCSC; K03E6.5a; c. elegans.
DR   CTD; 180458; -.
DR   WormBase; K03E6.5a; CE28585; WBGene00006741; unc-1.
DR   eggNOG; KOG2621; Eukaryota.
DR   GeneTree; ENSGT01030000234614; -.
DR   HOGENOM; CLU_024949_3_0_1; -.
DR   InParanoid; Q21190; -.
DR   PhylomeDB; Q21190; -.
DR   PRO; PR:Q21190; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006741; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q21190; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0005911; C:cell-cell junction; IDA:WormBase.
DR   GO; GO:0005921; C:gap junction; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0099106; F:ion channel regulator activity; IMP:WormBase.
DR   GO; GO:0010650; P:positive regulation of cell communication by electrical coupling; IMP:WormBase.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IMP:WormBase.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR043202; Band-7_stomatin-like.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR018080; Band_7/stomatin-like_CS.
DR   InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR   InterPro; IPR028522; Unc-1.
DR   PANTHER; PTHR10264; PTHR10264; 1.
DR   PANTHER; PTHR10264:SF72; PTHR10264:SF72; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PRINTS; PR00721; STOMATIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   PROSITE; PS01270; BAND_7; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..285
FT                   /note="Protein unc-1"
FT                   /id="PRO_0000094043"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         184
FT                   /note="E->V: In e580; no effect on unc-9 localization to
FT                   gap junction in PLM neurons."
FT                   /evidence="ECO:0000269|PubMed:27015090"
SQ   SEQUENCE   285 AA;  31657 MW;  FFBF5DB5FD50B9CD CRC64;
     MSNKERTEPQ WVTPSSNQDV PPDYETIGTI FGYALQALSW ILIIVTFPFS MCVCLKVIKE
     YERVVIFRIG RLVFGGARGP GMIFIIPCID TYRKIDLRVV SYAVPPQEIL SKDSVTVSVD
     AVVYFRTSDP IASVNNVDDA IYSTKLLAQT TLRNALGMKT LTEMLTEREA IAQLCETILD
     EGTEHWGVKV ERVEVKDIRL PQQLTRAMAA EAEAAREARA KVVAAEGEQK ASRALKEAAD
     VIQANPVALQ LRHLQALNSI AAEHNSTIVF PVPVEMFGAF MKKDQ