UNC36_CAEBR
ID UNC36_CAEBR Reviewed; 1254 AA.
AC A8XP97;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Voltage-dependent calcium channel unc-36 {ECO:0000250|UniProtKB:P34374};
DE AltName: Full=Pharyngeal calcium channel subunit alpha-2;
DE AltName: Full=Uncoordinated protein 36;
DE Flags: Precursor;
GN Name=unc-36; ORFNames=CBG16666;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: May act as an auxiliary subunit of the unc-2 voltage-gated
CC calcium channel which appears to trigger calcium-activated signaling
CC pathways that control the serotonin response. Inhibiting serotonin
CC sensitivity of the vulval muscles results in egg laying defects. May
CC act in both neurons and muscle cells to enhance motor activity as it is
CC required for coordinated movement. Has a role in neural depolarization-
CC induced calcium influx and pharyngeal pumping. Involved in restricting
CC the expression of the putative olfactory receptor str-2 to only one of
CC the two AWC neurons. {ECO:0000250|UniProtKB:P34374}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}.
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DR EMBL; HE600949; CAP34577.2; -; Genomic_DNA.
DR AlphaFoldDB; A8XP97; -.
DR SMR; A8XP97; -.
DR STRING; 6238.CBG16666; -.
DR WormBase; CBG16666a; CBP23420; WBGene00036546; Cbr-unc-36.
DR eggNOG; KOG2353; Eukaryota.
DR HOGENOM; CLU_260458_0_0_1; -.
DR InParanoid; A8XP97; -.
DR OMA; NDYFNIM; -.
DR OrthoDB; 69856at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; ISS:UniProtKB.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB.
DR GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR GO; GO:0018991; P:oviposition; ISS:UniProtKB.
DR GO; GO:0043050; P:pharyngeal pumping; ISS:UniProtKB.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0007210; P:serotonin receptor signaling pathway; ISS:UniProtKB.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF13768; VWA_3; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium channel; Calcium transport; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1254
FT /note="Voltage-dependent calcium channel unc-36"
FT /id="PRO_0000356225"
FT TOPO_DOM 20..1233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1234..1254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 250..479
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 558
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 757
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 838
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 903
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 923
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1254 AA; 144808 MW; BDA7538157F9C2A6 CRC64;
MRAVHLLLVL AIYITRTRSF NKESIKECAQ VLSEHMKETF SKISHETILK QNYEKLVEEE
QFDPRAELKR SKHRIEDYLK VRSQFAYKAK ISLEARSVKN DTSVNDPQSK SFIRFMSAKQ
GNDGTTIYES NHLGKKLKVN ETKSFNLTQN ANFYTLPTSS VSSAVHIPTP LYDRNEELLR
KIDWSDIDAV YRTNREETKD LAFQLFCSEA GYMRYYPAAS WFWDNQDEHL DLFDCRNTEW
YINSATNSKN VLIMLDMSGS MLGQRYEVAK QTTEAILETL SHNDYFNIMT FSKNTFLLDG
CNGTNGLLQA TMRNKKALRR KMDTYQSEGK AEYEKALPLA FSVLLDLKGS YALYTKEEMS
MMSGNATNDY QFHLELPEHV LAATRQYIDS INNGGGDNNR GACENVIMLI TDGAPNAYKK
IFDMYNADKK VRVFTFLVGD EAIDFNEVRE MACNNRGYMV HVANMADVDE KIHHYIRRMS
RVVGRHYKES GQLSWWTGVY RERLYLPRPE VFAEPVPITN QSFAVMNKMA SRRKIRLQKS
EARSRMFVTT VSYPVIVNET FMGVAAVNIP LTEIAQKSHP ANIGAKSYFF MLDQNGFVMT
HPQLRPIDPV TKYHKQNYNN MDLLELEVGQ NQNVRSSQKS QAVSDLVCES GANYAECVDD
LRKAVRKMII DCDNSDVQQL DVLYATELLD RVYPQTNTYY AECINHANFV LGLAVAKGDD
YRIIKKQKKY DFGRVKMDWM GDKRWKLHPH WRYCFLNDTD THMTKEEAFE IYAQQMSDSG
KAPLLCEYRR NLVEKLLLDM EATSNLIDSW DTQYSYMKNN LIHLAFFSTP SGMIRYYNLT
LQDYDYIDPY WSIFEHIGHL LSFEHAQESY NHFITDLNRK STDDRYYRRA VRMKDTIMFD
VSNNSKIWYK SETQLTGYGL NENLTMLGQA FKAIYLDKAV LGVSGYEFAF DHVVDTMAEH
GCPASDDRKW CLLLDEHAYV FFSNQNDISY EDYLVGKGKH ISQYFGGLNR IAQRAMALLV
ENKFYTKFTY TDNQAVCKAA KQVTLSAGRL RPFYHVFQFL MQTFNFMVRL ASQVSGGYLI
WLPNIQFTEA YTASFHEGTD VYPCPKQSSF YFSNKDGKNR PTSTHLVTGN RSERPCKMNA
KCSVKIEAAF VDGTNLVMVW ITQDKASENC YDESECSMDI PSAQVPFGFE EVKNDESCEN
LEKRKSKAND VCYSIDDDDS EVSVTNERRP CSLSPSSLVS IVPILVGFLH FYMF
