ID   UNC4_DANRE              Reviewed;         470 AA.
AC   Q50D79; Q1JQ36;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Homeobox protein unc-4 homolog;
DE   AltName: Full=Homeobox protein Uncx4.1;
GN   Name=uncx; Synonyms=uncx4.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15889082; DOI=10.1038/nature03512;
RA   Kawakami Y., Raya A., Raya R.M., Rodriguez-Esteban C., Belmonte J.C.;
RT   "Retinoic acid signalling links left-right asymmetric patterning and
RT   bilaterally symmetric somitogenesis in the zebrafish embryo.";
RL   Nature 435:165-171(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in somitogenesis and
CC       neurogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: In the somite, it is restricted to the caudal half
CC       of the newly formed somite and sclerotome.
CC       {ECO:0000269|PubMed:15889082}.
CC   -!- MISCELLANEOUS: Marker of antero-posterior subdivisions of the somite.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Unc-4 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY881012; AAX73253.1; -; mRNA.
DR   EMBL; BC116499; AAI16500.1; -; mRNA.
DR   RefSeq; NP_001018616.2; NM_001020780.2.
DR   AlphaFoldDB; Q50D79; -.
DR   STRING; 7955.ENSDARP00000055008; -.
DR   PaxDb; Q50D79; -.
DR   GeneID; 553947; -.
DR   KEGG; dre:553947; -.
DR   CTD; 553947; -.
DR   ZFIN; ZDB-GENE-050714-1; uncx4.1.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q50D79; -.
DR   OrthoDB; 1401774at2759; -.
DR   PhylomeDB; Q50D79; -.
DR   PRO; PR:Q50D79; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..470
FT                   /note="Homeobox protein unc-4 homolog"
FT                   /id="PRO_0000334627"
FT   DNA_BIND        101..160
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          83..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        20
FT                   /note="S -> G (in Ref. 1; AAX73253)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="G -> V (in Ref. 1; AAX73253)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        120
FT                   /note="S -> F (in Ref. 1; AAX73253)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   470 AA;  51726 MW;  67EAA35C5E8CC756 CRC64;
     MMDSRILEHP HAQFGGSLGS MVGMGFPYHL GHHHVYDISG HQLQSAAAVP FSIDGLLNGS
     CSGSVANSNP LLGSGCGVNG DSQYKLGDGG DPDKESPGCK RRRTRTNFTG WQLEELEKAS
     NESHYPDVFM REALALRLDL VESRVQVWFQ NRRAKWRKKE NTKKGPGRPA HNSHPTTCSG
     EPMDPEEIAR RELERLEKKK RKQERKLLKS QNKLLAGELF HTPGSDSDSG VSQSTDSEST
     PHTGPQHSAH RQQTEHICEQ HARHQRASTV NETAEPMDST RNSGLCPANG ITRASTLQKL
     NPFSVESLLA DSSPRRKTIL DFSQLPPQRP LVGKGHFLLY PITQPLGFIV PQTAMKQSHD
     SGNSGHHCST TDTSTSNQKN VNHLCRDNTG ASDELQRETK NSSIQSPSTS SEKCFSESNS
     PQKESENDSE STVTNSSQKE SISANLSEYS DRKSRSSADT NTDGEDVDMD