ID   UNC4_RAT                Reviewed;         530 AA.
AC   P97830;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Homeobox protein unc-4 homolog;
DE   AltName: Full=Homeobox protein Uncx4.1;
DE   AltName: Full=Paired-type homeodomain transcription factor 1;
GN   Name=Uncx; Synonyms=Phd1, Uncx4.1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Head;
RX   PubMed=8948581; DOI=10.1006/dbio.1996.0291;
RA   Saito T., Lo L., Anderson D.J., Mikoshiba K.;
RT   "Identification of novel paired homeodomain protein related to C. elegans
RT   unc-4 as a potential downstream target of MASH1.";
RL   Dev. Biol. 180:143-155(1996).
CC   -!- FUNCTION: Transcription factor involved in somitogenesis and
CC       neurogenesis. Required for the maintenance and differentiation of
CC       particular elements of the axial skeleton. May act upstream of PAX9.
CC       Plays a role in controlling the development of connections of
CC       hypothalamic neurons to pituitary elements, allowing central neurons to
CC       reach the peripheral blood circulation and to deliver hormones for
CC       control of peripheral functions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in a narrow layer adjacent to the
CC       ventricular zone of the dorsal spinal cord, preceding overt neuronal
CC       differentiation. {ECO:0000269|PubMed:8948581}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Unc-4 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; D87748; BAA13452.1; -; mRNA.
DR   RefSeq; NP_058875.1; NM_017179.1.
DR   AlphaFoldDB; P97830; -.
DR   STRING; 10116.ENSRNOP00000001730; -.
DR   PaxDb; P97830; -.
DR   GeneID; 29375; -.
DR   KEGG; rno:29375; -.
DR   UCSC; RGD:69361; rat.
DR   CTD; 340260; -.
DR   RGD; 69361; Uncx.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; P97830; -.
DR   OrthoDB; 1401774at2759; -.
DR   PhylomeDB; P97830; -.
DR   PRO; PR:P97830; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0001502; P:cartilage condensation; ISO:RGD.
DR   GO; GO:0035726; P:common myeloid progenitor cell proliferation; ISO:RGD.
DR   GO; GO:0021516; P:dorsal spinal cord development; ISO:RGD.
DR   GO; GO:0021889; P:olfactory bulb interneuron differentiation; ISO:RGD.
DR   GO; GO:0007389; P:pattern specification process; ISO:RGD.
DR   GO; GO:0045595; P:regulation of cell differentiation; ISO:RGD.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..530
FT                   /note="Homeobox protein unc-4 homolog"
FT                   /id="PRO_0000334626"
FT   DNA_BIND        109..168
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          90..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..423
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..503
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  53880 MW;  F5D5C0BD87ECF792 CRC64;
     MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAAAA ASVPFSIDGL
     LSGSCAAAAA SVVNPTPLLP AACGVAGESQ PFKLADSGDP DKESPGCKRR RTRTNFTGWQ
     LEELEKAFNE SHYPDVFMRE ALAVRLDLVE SRVQVWFQNR RAKWRKKENT KKGPGRPAHN
     SHPTTCSGEP MDPEEIARKE LEKMEKKKRK HEKKLLKSQS RHLHSPGGLS LHSAPSSDSD
     SGGGGLSPEP PEPPPPTASA KGPGAHGSGI AGSAPVPPGE PPAPGTCDPA FYPSQRSGAG
     SQPRLGRPAD KDTVPCGPGA ASTAGLPKAS PFSVESLLSD SPPRRKATPA NTAATAGLDF
     TPGLPCAPRT LIGKGHFLLY PITQPLGFLV PQAALKGGAG PELVPKDAPP APPAPPAPPA
     QASFGAFPGP VGAADPAFAR RSPEVVASPG PPAPASFRGL AAAAAESGAG DCADAGTVCP
     AAPPPPPLET SPGPGPRAPS PPGEPATCGA AEPGAATGSS PPEGEEVDMD