ID   UNC50_BOVIN             Reviewed;         259 AA.
AC   Q3ZBG6; Q5E989;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein unc-50 homolog;
GN   Name=UNC50;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the cell surface expression of neuronal nicotinic
CC       receptors (By similarity). Binds RNA (By similarity).
CC       {ECO:0000250|UniProtKB:O55227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:O55227}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O55227}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q53HI1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q53HI1}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3ZBG6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3ZBG6-2; Sequence=VSP_029085;
CC   -!- SIMILARITY: Belongs to the unc-50 family. {ECO:0000305}.
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DR   EMBL; BT021031; AAX09048.1; -; mRNA.
DR   EMBL; BC103305; AAI03306.1; -; mRNA.
DR   RefSeq; NP_001014921.1; NM_001014921.1. [Q3ZBG6-2]
DR   RefSeq; XP_005212372.1; XM_005212315.3. [Q3ZBG6-1]
DR   AlphaFoldDB; Q3ZBG6; -.
DR   STRING; 9913.ENSBTAP00000019807; -.
DR   PaxDb; Q3ZBG6; -.
DR   Ensembl; ENSBTAT00000019807; ENSBTAP00000019807; ENSBTAG00000014877. [Q3ZBG6-1]
DR   GeneID; 513629; -.
DR   KEGG; bta:513629; -.
DR   CTD; 25972; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014877; -.
DR   eggNOG; KOG3012; Eukaryota.
DR   GeneTree; ENSGT00390000018553; -.
DR   HOGENOM; CLU_066239_0_0_1; -.
DR   InParanoid; Q3ZBG6; -.
DR   OMA; ISTLMWV; -.
DR   OrthoDB; 1351297at2759; -.
DR   TreeFam; TF105624; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000014877; Expressed in oocyte and 103 other tissues.
DR   ExpressionAtlas; Q3ZBG6; baseline and differential.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR   InterPro; IPR007881; UNC-50.
DR   PANTHER; PTHR12841; PTHR12841; 1.
DR   Pfam; PF05216; UNC-50; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Golgi apparatus; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome; RNA-binding; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..259
FT                   /note="Protein unc-50 homolog"
FT                   /id="PRO_0000308960"
FT   TOPO_DOM        1..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..115
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..163
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..187
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..259
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53HI1"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53HI1"
FT   VAR_SEQ         180..181
FT                   /note="NH -> NPD (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_029085"
SQ   SEQUENCE   259 AA;  30352 MW;  5F3D4B6562CCC0DC CRC64;
     MLPSTSVNSP AQGNGVLSSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA WQMLYLFTSP
     QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG FVLDMGFFET IKLLLWVVFI
     DCVGVGLLIS TLMWFISNKY LVKRQSRDYD VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN
     HVILTDTFIG YLVGNTLWLV AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL
     ALGWNFTHTL CSFYKYRVK