UNC50_CAEEL
ID UNC50_CAEEL Reviewed; 301 AA.
AC Q10045;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein unc-50;
DE AltName: Full=Uncoordinated protein 50;
GN Name=unc-50; ORFNames=T07A5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=10980252; DOI=10.1016/s0006-8993(00)02692-5;
RA Fitzgerald J., Kennedy D., Viseshakul N., Cohen B.N., Mattick J.,
RA Bateman J.F., Forsayeth J.R.;
RT "UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-
RT binding protein.";
RL Brain Res. 877:110-123(2000).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=17853888; DOI=10.1038/sj.emboj.7601858;
RA Eimer S., Gottschalk A., Hengartner M., Horvitz H.R., Richmond J.,
RA Schafer W.R., Bessereau J.-L.;
RT "Regulation of nicotinic receptor trafficking by the transmembrane Golgi
RT protein UNC-50.";
RL EMBO J. 26:4313-4323(2007).
CC -!- FUNCTION: Required for cell surface expression of acetylcholine
CC receptors in body-wall muscles. {ECO:0000269|PubMed:17853888}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:17853888}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17853888}.
CC -!- DEVELOPMENTAL STAGE: Ubiquitously expressed, from early embryogenesis
CC to adulthood. {ECO:0000269|PubMed:17853888}.
CC -!- SIMILARITY: Belongs to the unc-50 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z48055; CAA88132.2; -; Genomic_DNA.
DR PIR; T24631; T24631.
DR RefSeq; NP_499279.2; NM_066878.3.
DR AlphaFoldDB; Q10045; -.
DR IntAct; Q10045; 2.
DR MINT; Q10045; -.
DR STRING; 6239.T07A5.2; -.
DR iPTMnet; Q10045; -.
DR EPD; Q10045; -.
DR PaxDb; Q10045; -.
DR PeptideAtlas; Q10045; -.
DR EnsemblMetazoa; T07A5.2.1; T07A5.2.1; WBGene00006785.
DR GeneID; 176443; -.
DR KEGG; cel:CELE_T07A5.2; -.
DR UCSC; T07A5.2; c. elegans.
DR CTD; 176443; -.
DR WormBase; T07A5.2; CE36501; WBGene00006785; unc-50.
DR eggNOG; KOG3012; Eukaryota.
DR GeneTree; ENSGT00390000018553; -.
DR HOGENOM; CLU_066239_1_0_1; -.
DR InParanoid; Q10045; -.
DR OMA; ISTLMWV; -.
DR OrthoDB; 1351297at2759; -.
DR PhylomeDB; Q10045; -.
DR PRO; PR:Q10045; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006785; Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:WormBase.
DR GO; GO:0097120; P:receptor localization to synapse; IMP:WormBase.
DR GO; GO:0006937; P:regulation of muscle contraction; IGI:UniProtKB.
DR InterPro; IPR007881; UNC-50.
DR PANTHER; PTHR12841; PTHR12841; 1.
DR Pfam; PF05216; UNC-50; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..301
FT /note="Protein unc-50"
FT /id="PRO_0000065452"
FT TOPO_DOM 1..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..142
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..221
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..301
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 34739 MW; 186A5B6AE302DDEA CRC64;
MSSQPRGSGT QPGPSQSPIS QRNFRYEPAR SGYTSPGQYS TYSTSTADRV GCLTAVRMSA
FAKLSRFTRR LVHIRQMDFE FALWQMLYLL IQPSKVYKNF IYRKRTKDQF ARDDPAFLVL
LALSLLFSSI FYAYALGLEK IGFFTFFLWS VFVDCIGVGV VIATVLWWVS NRFLRKVRDQ
DVEWGYCFDV HLNAFFPMLI LLHVIVPILY PTLIDSPAFL SILLGNTFWF LAACYYVYIT
FLGYTALPIL HKTQYFLYPI SFIFMFFVAT LTGGWNISRT ALNFYHSRAE PHKFAPQHGG
L
