ID   UNC50_DANRE             Reviewed;         259 AA.
AC   Q7ZUU1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein unc-50 homolog;
GN   Name=unc50;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the cell surface expression of neuronal nicotinic
CC       receptors (By similarity). Binds RNA (By similarity).
CC       {ECO:0000250|UniProtKB:O55227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:O55227}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O55227}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q53HI1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q53HI1}.
CC   -!- SIMILARITY: Belongs to the unc-50 family. {ECO:0000305}.
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DR   EMBL; BC047831; AAH47831.1; -; mRNA.
DR   RefSeq; NP_956541.1; NM_200247.1.
DR   AlphaFoldDB; Q7ZUU1; -.
DR   STRING; 7955.ENSDARP00000059211; -.
DR   PaxDb; Q7ZUU1; -.
DR   GeneID; 393217; -.
DR   KEGG; dre:393217; -.
DR   CTD; 25972; -.
DR   ZFIN; ZDB-GENE-040426-907; unc50.
DR   eggNOG; KOG3012; Eukaryota.
DR   InParanoid; Q7ZUU1; -.
DR   OrthoDB; 1351297at2759; -.
DR   PhylomeDB; Q7ZUU1; -.
DR   PRO; PR:Q7ZUU1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0034394; P:protein localization to cell surface; ISS:UniProtKB.
DR   InterPro; IPR007881; UNC-50.
DR   PANTHER; PTHR12841; PTHR12841; 1.
DR   Pfam; PF05216; UNC-50; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Nucleus; Reference proteome; RNA-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..259
FT                   /note="Protein unc-50 homolog"
FT                   /id="PRO_0000308964"
FT   TOPO_DOM        1..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..110
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..198
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..259
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  30554 MW;  38E63EEF9E330576 CRC64;
     MLPTSSPQIH RNGSLSERDA ARHTAGAKRY KYLRRLLHFR QMDFEFAVWQ MLYLFTSPQK
     VYRNFHYRKQ TKDQWARDDP AFLVLLSIWL CVSTVGFGLV LDMGFVETLT LLLWVVFIDC
     IGVGLLISTL MWFVTNKYLM KHPNRDYDVE WGYAFDVHLN AFYPLLVILH FLQLFFINHV
     VVISSDWFLG YFVGNTMWLI AIGYYVYITF LGYSALPFLK NTVVLLYPFA LLGLLYVLSI
     SLGWNFTKGL CWFYKHRVQ