UNC53_CAEEL
ID UNC53_CAEEL Reviewed; 1654 AA.
AC Q7YSI9; Q7YSI0; Q7YXD0; Q8MLZ1; Q8MM94; Q8MV03;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Adapter protein unc-53;
DE AltName: Full=Uncoordinated protein 53;
GN Name=unc-53; ORFNames=F45E10.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, AND INTERACTION WITH
RP SEM-5.
RX PubMed=12091307; DOI=10.1242/dev.129.14.3367;
RA Stringham E., Pujol N., Vandekerckhove J., Bogaert T.;
RT "unc-53 controls longitudinal migration in C. elegans.";
RL Development 129:3367-3379(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP INTERACTION WITH CMD-1.
RX PubMed=17854888; DOI=10.1016/j.ceca.2007.07.008;
RA Shen X., Valencia C.A., Gao W., Cotten S.W., Dong B., Huang B.C., Liu R.;
RT "Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome.";
RL Cell Calcium 43:444-456(2008).
CC -!- FUNCTION: Involved in the migration and outgrowth of muscles, axons and
CC excretory canals. {ECO:0000269|PubMed:12091307}.
CC -!- SUBUNIT: Interacts with sem-5 (PubMed:12091307). Interacts with cmd-1
CC in the presence of Ca(2+) (PubMed:17854888).
CC {ECO:0000269|PubMed:12091307, ECO:0000269|PubMed:17854888}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=c;
CC IsoId=Q7YSI9-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q7YSI9-2; Sequence=VSP_025273;
CC Name=b;
CC IsoId=Q7YSI9-3; Sequence=VSP_025272, VSP_025274;
CC Name=e;
CC IsoId=Q7YSI9-4; Sequence=VSP_025270;
CC Name=d;
CC IsoId=Q7YSI9-5; Sequence=VSP_025271;
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
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DR EMBL; AF504312; AAM22693.1; -; mRNA.
DR EMBL; Z50109; CAD44091.1; -; Genomic_DNA.
DR EMBL; Z47810; CAD44091.1; JOINED; Genomic_DNA.
DR EMBL; Z50109; CAD44092.1; -; Genomic_DNA.
DR EMBL; Z47810; CAD44092.1; JOINED; Genomic_DNA.
DR EMBL; Z47810; CAD44132.1; -; Genomic_DNA.
DR EMBL; Z50109; CAD44132.1; JOINED; Genomic_DNA.
DR EMBL; Z47810; CAD44133.1; -; Genomic_DNA.
DR EMBL; Z50109; CAD44133.1; JOINED; Genomic_DNA.
DR EMBL; Z50109; CAD89729.3; -; Genomic_DNA.
DR EMBL; Z47810; CAD89729.3; JOINED; Genomic_DNA.
DR EMBL; Z47810; CAD89730.3; -; Genomic_DNA.
DR EMBL; Z50109; CAD89730.3; JOINED; Genomic_DNA.
DR EMBL; Z50109; CAD91624.1; -; Genomic_DNA.
DR EMBL; Z47810; CAD91624.1; JOINED; Genomic_DNA.
DR EMBL; Z47810; CAD91631.1; -; Genomic_DNA.
DR EMBL; Z47810; CAD91632.1; -; Genomic_DNA.
DR EMBL; Z50109; CAD91632.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001022169.1; NM_001026998.3. [Q7YSI9-3]
DR RefSeq; NP_001022170.1; NM_001026999.5. [Q7YSI9-1]
DR RefSeq; NP_001022171.1; NM_001027000.3. [Q7YSI9-5]
DR RefSeq; NP_001022172.1; NM_001027001.3. [Q7YSI9-4]
DR RefSeq; NP_741045.1; NM_171039.2. [Q7YSI9-2]
DR AlphaFoldDB; Q7YSI9; -.
DR SMR; Q7YSI9; -.
DR BioGRID; 40003; 5.
DR IntAct; Q7YSI9; 1.
DR STRING; 6239.F45E10.1c; -.
DR EPD; Q7YSI9; -.
DR PaxDb; Q7YSI9; -.
DR PRIDE; Q7YSI9; -.
DR EnsemblMetazoa; F45E10.1a.1; F45E10.1a.1; WBGene00006788. [Q7YSI9-2]
DR EnsemblMetazoa; F45E10.1b.1; F45E10.1b.1; WBGene00006788. [Q7YSI9-3]
DR EnsemblMetazoa; F45E10.1c.1; F45E10.1c.1; WBGene00006788. [Q7YSI9-1]
DR EnsemblMetazoa; F45E10.1d.1; F45E10.1d.1; WBGene00006788. [Q7YSI9-5]
DR EnsemblMetazoa; F45E10.1e.1; F45E10.1e.1; WBGene00006788. [Q7YSI9-4]
DR GeneID; 174693; -.
DR UCSC; F45E10.1a; c. elegans. [Q7YSI9-1]
DR CTD; 174693; -.
DR WormBase; F45E10.1a; CE31346; WBGene00006788; unc-53. [Q7YSI9-2]
DR WormBase; F45E10.1b; CE31347; WBGene00006788; unc-53. [Q7YSI9-3]
DR WormBase; F45E10.1c; CE33783; WBGene00006788; unc-53. [Q7YSI9-1]
DR WormBase; F45E10.1d; CE34019; WBGene00006788; unc-53. [Q7YSI9-5]
DR WormBase; F45E10.1e; CE34020; WBGene00006788; unc-53. [Q7YSI9-4]
DR eggNOG; ENOG502QPT3; Eukaryota.
DR GeneTree; ENSGT00940000168701; -.
DR InParanoid; Q7YSI9; -.
DR OMA; LECYKNT; -.
DR OrthoDB; 113614at2759; -.
DR PRO; PR:Q7YSI9; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00006788; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q7YSI9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0051015; F:actin filament binding; TAS:WormBase.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISS:WormBase.
DR GO; GO:0007411; P:axon guidance; IMP:WormBase.
DR GO; GO:0043057; P:backward locomotion; IMP:WormBase.
DR GO; GO:0048858; P:cell projection morphogenesis; IMP:WormBase.
DR GO; GO:0016204; P:determination of muscle attachment site; IMP:WormBase.
DR GO; GO:0007617; P:mating behavior; IMP:WormBase.
DR GO; GO:0008078; P:mesodermal cell migration; IGI:WormBase.
DR GO; GO:0008045; P:motor neuron axon guidance; IGI:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0018991; P:oviposition; IMP:WormBase.
DR GO; GO:0045773; P:positive regulation of axon extension; IMP:WormBase.
DR GO; GO:0048842; P:positive regulation of axon extension involved in axon guidance; IMP:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; IGI:WormBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0007165; P:signal transduction; IPI:WormBase.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784; PTHR12784; 1.
DR Pfam; PF00307; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calmodulin-binding; Coiled coil;
KW Developmental protein; Reference proteome.
FT CHAIN 1..1654
FT /note="Adapter protein unc-53"
FT /id="PRO_0000286979"
FT DOMAIN 6..115
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 128..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 962..994
FT /evidence="ECO:0000255"
FT COILED 1152..1184
FT /evidence="ECO:0000255"
FT COMPBIAS 145..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..420
FT /note="Missing (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_025270"
FT VAR_SEQ 1..134
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_025271"
FT VAR_SEQ 797..908
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_025272"
FT VAR_SEQ 838..908
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:12091307"
FT /id="VSP_025273"
FT VAR_SEQ 1093
FT /note="W -> WALSVDSQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_025274"
FT CONFLICT 1257
FT /note="P -> S (in Ref. 1; AAM22693)"
FT /evidence="ECO:0000305"
FT CONFLICT 1600
FT /note="E -> K (in Ref. 1; AAM22693)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1654 AA; 181427 MW; D33B8C651BAF0453 CRC64;
MTTSNVELIP IYTDWANRHL SKGSLSKSIR DISNDFRDYR LVSQLINVIV PINEFSPAFT
KRLAKITSNL DGLETCLDYL KNLGLDCSKL TKTDIDSGNL GAVLQLLFLL STYKQKLRQL
KKDQKKLEQL PTSIMPPAVS KLPSPRVATS ATASATNPNS NFPQMSTSRL QTPQSRISKI
DSSKIGIKPK TSGLKPPSSS TTSSNNTNSF RPSSRSSGNN NVGSTISTSA KSLESSSTYS
SISNLNRPTS QLQKPSRPQT QLVRVATTTK IGSSKLAAPK AVSTPKLASV KTIGAKQEPD
NSGGGGGGML KLKLFSSKNP SSSSNSPQPT RKAAAVPQQQ TLSKIAAPVK SGLKPPTSKL
GSATSMSKLC TPKVSYRKTD APIISQQDSK RCSKSSEEES GYAGFNSTSP TSSSTEGSLS
MHSTSSKSST SDEKSPSSDD LTLNASIVTA IRQPIAATPV SPNIINKPVE EKPTLAVKGV
KSTAKKDPPP AVPPRDTQPT IGVVSPIMAH KKLTNDPVIS EKPEPEKLQS MSIDTTDVPP
LPPLKSVVPL KMTSIRQPPT YDVLLKQGKI TSPVKSFGYE QSSASEDSIV AHASAQVTPP
TKTSGNHSLE RRMGKNKTSE SSGYTSDAGV AMCAKMREKL KEYDDMTRRA QNGYPDNFED
SSSLSSGISD NNELDDISTD DLSGVDMATV ASKHSDYSHF VRHPTSSSSK PRVPSRSSTS
VDSRSRAEQE NVYKLLSQCR TSQRGAAATS TFGQHSLRSP GYSSYSPHLS VSADKDTMSM
HSQTSRRPSS QKPSYSGQFH SLDRKCHLQE FTSTEHRMAA LLSPRRVPNS MSKYDSSAAA
LNASGMSRSM ILLESLSPRP PRRHQSPADS CIITASPSAP RRSHSPRGPT ARIPLSLASS
PVHVNNNWGS YSARSRGGSS TGIYGETFQL HRLSDEKSPA HSAKSEMGSQ LSLASTTAYG
SLNEKYEHAI RDMARDLECY KNTVDSLTKK QENYGALFDL FEQKLRKLTQ HIDRSNLKPE
EAIRFRQDIA HLRDISNHLA SNSAHANEGA GELLRQPSLE SVASHRSSMS SSSKSSKQEK
ISLSSFGKNK KSWIRSSLSK FTKKKNKNYD EAHMPSISGS QGTLDNIDVI ELKQELKERD
SALYEVRLDN LDRAREVDVL RETVNKLKTE NKQLKKEVDK LTNGPATRAS SRASIPVIYD
DEHVYDAACS STSASQSSKR SSGCNSIKVT VNVDIAGEIS SIVNPDKEII VGYLAMPTSQ
SCWKDIDVSI LGLFEVYLSR IDVEHQLGID ARDSILGYQI GELRRVIGDS TTMITSHPTD
ILTSSTTIRM FMHGAAQSRV DSLVLDMLLP KQMILQLVKS ILTERRLVLA GATGIGKSKL
AKTLAAYVSI RTNQSEDSIV NISIPENNKE ELLQVERRLE KILRSKESCI VILDNIPKNR
IAFVVSVFAN VPLQNNEGPF VVCTVNRYQI PELQIHHNFK MSVMSNRLEG FILRYLRRRA
VEDEYRLTVQ MPSELFKIID FFPIALQAVN NFIEKTNSVD VTVGPRACLN CPLTVDGSRE
WFIRLWNENF IPYLERVARD GKKTFGRCTS FEDPTDIVSE KWPWFDGENP ENVLKRLQLQ
DLVPSPANSS RQHFNPLESL IQLHATKHQT IDNI
