ID   UNC58_CAEBR             Reviewed;         593 AA.
AC   Q622X0; A8WRQ8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Uncoordinated protein 58;
GN   Name=unc-58 {ECO:0000250|UniProtKB:Q22271}; ORFNames=CBG01980;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Has a role in mobility, possibly in the transport of
CC       potassium in muscles. {ECO:0000250|UniProtKB:Q22271}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000255}.
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DR   EMBL; HE601451; CAP23166.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q622X0; -.
DR   STRING; 6238.CBG01980; -.
DR   WormBase; CBG01980a; CBP46739; WBGene00025136; Cbr-unc-58.
DR   eggNOG; KOG1418; Eukaryota.
DR   HOGENOM; CLU_032755_1_0_1; -.
DR   InParanoid; Q622X0; -.
DR   OMA; VSCICLY; -.
DR   OrthoDB; 1033932at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR   GO; GO:0006936; P:muscle contraction; ISS:UniProtKB.
DR   GO; GO:0007567; P:parturition; ISS:UniProtKB.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; PTHR11003; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
PE   3: Inferred from homology;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..593
FT                   /note="Uncoordinated protein 58"
FT                   /id="PRO_0000306198"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   593 AA;  67584 MW;  6AA6B859574EEB5C CRC64;
     MFFYSPNVAS SSSASHRRGT LTHQHHLHVG HLDTRLSVQI PEILSRNFGH HDPERARLVP
     EHLRFLVDEN QELWTGGNQP PVGILELCAA SPVDSVFSTN DARRHSQRKL ILRRPTISIQ
     EDGKIIIDHV TARWEGANIN SQSALLDADD GATVITDTIK DDQEDKEPKS CPQQTVKYIK
     ILLPHVILVS VLIGYLCLGA WILMLLETRT ELLSRSKKLV RLTNLMSNFT AESWRMLSDA
     QHGSITMDEG EWAATFREWM VRVSETVDDR RPIRRELNRP DDLSNMHNKW TFPTALLYVL
     TVLTTCGYGE VSVDTDVGKV FSVAFALVGI PLMFITAADI GKFLSETLLK FVSFWNRSVR
     KVKQWMSRVR HGRRKSLQST GGQNDTLDIL GVDGTEEKLW FPIGAYVSCI CLYCSMGSAM
     FINWERTWSF IHAFHFGFNL IVTVGLGDIV VTDYIFLSLI VAFVIVGLSV VTMCVDLAST
     HLKAYFTRIH YFGRAKRFLG MSEELKEIVA LLGAMRRKKG GKVTWNDVRD FLDNELRDRP
     FEPHELLMKL RFIDETSSGM STIRHNSFQS DFFRESEYIR RVAALRPEQP AYL