UNC5C_CHICK
ID UNC5C_CHICK Reviewed; 931 AA.
AC Q7T2Z5;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Netrin receptor UNC5C;
DE AltName: Full=Protein unc-5 homolog 3;
DE Short=cUNC-5H3;
DE AltName: Full=Protein unc-5 homolog C;
DE Flags: Precursor;
GN Name=UNC5C;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12799087; DOI=10.1016/s1567-133x(03)00007-3;
RA Guan W., Condic M.L.;
RT "Characterization of Netrin-1, Neogenin and cUNC-5H3 expression during
RT chick dorsal root ganglia development.";
RL Gene Expr. Patterns 3:369-373(2003).
RN [2]
RP FUNCTION.
RX PubMed=28483977; DOI=10.1523/jneurosci.2617-16.2017;
RA Shao Q., Yang T., Huang H., Alarmanazi F., Liu G.;
RT "Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates
RT Netrin-1 Repulsion.";
RL J. Neurosci. 37:5620-5633(2017).
CC -!- FUNCTION: Receptor for netrin required for axon guidance (By
CC similarity). Mediates axon repulsion of neuronal growth cones in the
CC developing nervous system upon ligand binding (By similarity). Involved
CC in dorsal root ganglion axon projection towards the spinal cord
CC (PubMed:28483977). {ECO:0000250|UniProtKB:O08747,
CC ECO:0000269|PubMed:28483977}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08747};
CC Single-pass type I membrane protein {ECO:0000255}. Cell surface
CC {ECO:0000250|UniProtKB:O95185}. Synapse, synaptosome
CC {ECO:0000250|UniProtKB:Q761X5}. Cell projection, axon
CC {ECO:0000250|UniProtKB:O08747}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:O08747}. Cell projection, growth cone
CC {ECO:0000250|UniProtKB:O08747}. Cell projection, lamellipodium
CC {ECO:0000250|UniProtKB:O08747}. Cell projection, filopodium
CC {ECO:0000250|UniProtKB:O08747}.
CC -!- TISSUE SPECIFICITY: Restricted to proprioceptive neurons.
CC {ECO:0000269|PubMed:12799087}.
CC -!- SIMILARITY: Belongs to the unc-5 family. {ECO:0000305}.
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DR EMBL; AY187310; AAO67275.1; -; mRNA.
DR RefSeq; NP_989782.1; NM_204451.1.
DR AlphaFoldDB; Q7T2Z5; -.
DR SMR; Q7T2Z5; -.
DR STRING; 9031.ENSGALP00000036855; -.
DR PaxDb; Q7T2Z5; -.
DR GeneID; 395101; -.
DR KEGG; gga:395101; -.
DR CTD; 8633; -.
DR VEuPathDB; HostDB:geneid_395101; -.
DR eggNOG; KOG1480; Eukaryota.
DR InParanoid; Q7T2Z5; -.
DR PhylomeDB; Q7T2Z5; -.
DR PRO; PR:Q7T2Z5; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:1990791; P:dorsal root ganglion development; IMP:UniProtKB.
DR CDD; cd08799; Death_UNC5C; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 2.20.100.10; -; 2.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042154; Death_UNC5C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; PTHR12582; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF82895; SSF82895; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Developmental protein; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
KW Reference proteome; Repeat; Signal; Synapse; Synaptosome; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..931
FT /note="Netrin receptor UNC5C"
FT /id="PRO_0000036078"
FT TOPO_DOM 40..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..931
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 62..159
FT /note="Ig-like"
FT DOMAIN 161..256
FT /note="Ig-like C2-type"
FT DOMAIN 260..314
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 316..368
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 530..664
FT /note="ZU5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00485"
FT DOMAIN 850..929
FT /note="Death"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..144
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 95..142
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 188..239
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 272..309
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 276..313
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 287..299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 328..362
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 332..367
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
FT DISULFID 340..352
FT /evidence="ECO:0000250|UniProtKB:Q6ZN44"
SQ SEQUENCE 931 AA; 102906 MW; 1E23A0D84F2E2C62 CRC64;
MGKGLEGTAA RCGLGMGYLL HSVVLPALAV LGASRPGSAA QDDDFFHELP ETFPSDPPEP
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVC
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL
EQEVLLQCRP PEGIPVAEVE WLKNEEVIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS ACNSRCGRGF QKRTRTCTNP APLNGGAFCE
GQNVQKIACT TLCPVDGKWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCEGLVLQSK
NCTDGLCMQA APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK
VYNTSGAVTP QDELSDFSSK LSPQITQSLL ENETLNVKNQ SLARQTDPSC TAFGTFNSLG
GHLVIPNSGV SLLIPAGAVP QGRVYEMYVT VHRKEGMRPP VEDSQTLLTP VVSCGPPGAL
LTRPVVLTMH HCAEPNMDDW QIQLKHQAGQ GPWEDVVVVG EENFTTPCYI QLDPEACHIL
TETLSTYALV GQSITKAAAK RLKLAIFGPL SCSSLEYSIR VYCLDDTQDA LKEVLQLERQ
MGGQLLEEPK TLHFKGSTHN LRLSIHDIAH SLWKSKLPAK YQEIPFYHIW SGCQRNLHCT
FTLERFSLNT LELVCKLCVR QVEGEGQIFQ LNCSVSEEPT GIDYPIMDSA GSITTIVGPN
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLKLDRYLN YFATKSSPTG VILDLWEAQN
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGN Y
