ID   UNC5_PETMA              Reviewed;         199 AA.
AC   Q9PVD5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Netrin receptor unc-5 homolog;
DE   Flags: Fragment;
GN   Name=UNC-5;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Brain;
RX   PubMed=11228949; DOI=10.1177/154596830001400106;
RA   Shifman M.I., Selzer M.E.;
RT   "Expression of the netrin receptor UNC-5 in lamprey brain: modulation by
RT   spinal cord transection.";
RL   Neurorehabil. Neural Repair 14:49-58(2000).
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the spinal cord, primarily in neurons
CC       of the lateral gray matter and in dorsal cells. Also expressed in
CC       reticulospinal neurons. {ECO:0000269|PubMed:11228949}.
CC   -!- DEVELOPMENTAL STAGE: Following spinal cord transection, it is strongly
CC       down-regulated at two weeks, during the period of axon dieback. Up-
CC       regulated at three weeks, when many axons are beginning to regenerate.
CC       {ECO:0000269|PubMed:11228949}.
CC   -!- PTM: Phosphorylated on cytoplasmic tyrosine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the unc-5 family. {ECO:0000305}.
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DR   EMBL; AF129475; AAF00103.1; -; mRNA.
DR   AlphaFoldDB; Q9PVD5; -.
DR   SMR; Q9PVD5; -.
DR   STRING; 7757.ENSPMAP00000010563; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR037936; UNC5.
DR   PANTHER; PTHR12582; PTHR12582; 1.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome.
FT   CHAIN           <1..>199
FT                   /note="Netrin receptor unc-5 homolog"
FT                   /id="PRO_0000189079"
FT   TOPO_DOM        <1..>199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          103..192
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        172
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..175
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
FT   NON_TER         199
SQ   SEQUENCE   199 AA;  22911 MW;  C41F9CFC66D8DC0B CRC64;
     HREEQARYIV KNKPVTMSCA ASPATQIYFK CNGEWLHQKA HHIEEREDET TGRSVREVQT
     DVSRQQVEEL FGLEDYWCQC VAWSAAGTSK SRKAYVRLAY LRKNFEQKPL GKYALLDHEV
     LLHCRPPDAI PQAEVEWLKS EEIIDPVIDQ NFYITVDHNL IIKQTRLADS ANYTCVAKNL
     VAKRRSSTAT ITVYVNGGW