UNC62_CAEBR
ID UNC62_CAEBR Reviewed; 725 AA.
AC A8WL06;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Homeobox protein unc-62;
DE AltName: Full=Uncoordinated protein 62;
GN Name=unc-62; ORFNames=CBG24578;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Acts redundantly with ceh-20 and ceh-40 to perform
CC overlapping roles during embryogenesis. Required for postembryonic
CC development of the ectoderm, including the Q, V and P cell lineages,
CC playing a crucial role in ensuring that these cells and their
CC descendants undergo their invariant patterns of cell division,
CC migration, fusion and morphogenesis. Has a role in the mig-13 pathway
CC to promote anterior migration of neuroblasts in the Q lineage. Required
CC for multiple roles in regulating vulva development (By similarity).
CC {ECO:0000250|UniProtKB:Q9N5D6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000255}.
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DR EMBL; HE601496; CAP21151.3; -; Genomic_DNA.
DR AlphaFoldDB; A8WL06; -.
DR SMR; A8WL06; -.
DR STRING; 6238.CBG24578; -.
DR WormBase; CBG24578a; CBP42144; WBGene00042654; Cbr-unc-62.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_023139_3_0_1; -.
DR InParanoid; A8WL06; -.
DR OMA; AATAMHY; -.
DR OrthoDB; 1126341at2759; -.
DR Proteomes; UP000008549; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..725
FT /note="Homeobox protein unc-62"
FT /id="PRO_0000341482"
FT DOMAIN 133..218
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 552..614
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 214..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..403
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 78935 MW; 5C5544F95C0361D4 CRC64;
MSADSKVWAH ASADTWTTAQ GISTYDLDTS SIKREKIDCH EQFNDGYGPP PGTASTDAVS
YAADPTAYFN LYTNMGAAPT TTPMMHHEMG EAMKRDKEAI YAHPLYPLLV VLFEKCELAT
STPRETSRDG TTSSDVCSSA SFKDDLNEFV KHTQENADKQ YYQPNPQLDQ IMLQSIQMLR
FHLLELEKVH ELCDNFCNRY VTCLKGKMPL DIVGDERASS SQPPMSPGSM GHHGHSGSPS
MGGAGAATPM HYPPPYEPQS VPLPENVLGG GHPLEMFPGS SMAYAMAGMA AAAASSSSSQ
PQPGDHPLAN GGTLHSTAGA SQTLLPIAVS SPSTCSSGGL RQDSTPLSGE TPMANGNSMD
SISEAERIRR RFYMCVIVSA GPSSSSLHQH HLHHPHHFPH HQLQPPAHHQ DFLLPPPPQN
IIEQSLHCAG VSMLDASLIP PSSSSSASEY HGDMMSHMYS HHDVYHHQDM TYTDYGDYGT
PDVVMMSSSD VKMEDAASVS SSKSGGKKQQ PGTPNGRVGK SRGRDEFSVC GSNEDGRDSV
LSDSANGSQN GKRKVPKVFS KEAITKFRAW LFQNLAHPYP SEEQKKQLAK ETGLTILQVN
NWFINARRRI VQPMIDQNNR AGRTPHMNVC KNRRRNRSEQ SPGPSPDSES DSGANYSPDP
TSLAAATAMH YPGAELYMQR TMNYGGFQPF PNPAMQFMNP MMGFPVAPAV DAISQQWIDL
SAPHE
