UNC79_HUMAN
ID UNC79_HUMAN Reviewed; 2635 AA.
AC Q9P2D8; B5MDL6; Q6ZUT7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2013, sequence version 4.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein unc-79 homolog;
GN Name=UNC79; Synonyms=KIAA1409;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1458 (ISOFORM 2).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-2635 (ISOFORM 3), AND VARIANT
RP ILE-1670.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [4]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R.;
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=32494638; DOI=10.1126/sciadv.aaz3154;
RA Chua H.C., Wulf M., Weidling C., Rasmussen L.P., Pless S.A.;
RT "The NALCN channel complex is voltage sensitive and directly modulated by
RT extracellular calcium.";
RL Sci. Adv. 6:eaaz3154-eaaz3154(2020).
CC -!- FUNCTION: Auxiliary subunit of the NALCN sodium channel complex, a
CC voltage-gated ion channel responsible for the resting Na(+)
CC permeability that controls neuronal excitability. Activated by
CC neuropeptides substance P, neurotensin, and extracellular calcium that
CC regulates neuronal excitability by controlling the sizes of NALCN-
CC dependent sodium-leak current. {ECO:0000250|UniProtKB:Q8BLN6}.
CC -!- SUBUNIT: NALCN complex consists of NALCN and auxiliary subunits, UNC79,
CC UNC80 and NACL1. These auxiliary subunits are essential for the NALCN
CC channel function (By similarity). UNC80 bridges NALCN to UNC79 (By
CC similarity). {ECO:0000250|UniProtKB:Q8BLN6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32494638};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9P2D8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P2D8-2; Sequence=VSP_030583;
CC Name=3;
CC IsoId=Q9P2D8-3; Sequence=VSP_030584;
CC -!- SIMILARITY: Belongs to the unc-79 family. {ECO:0000305}.
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DR EMBL; AL122023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK125327; BAC86131.1; -; mRNA.
DR EMBL; AB037830; BAA92647.2; -; mRNA.
DR CCDS; CCDS9911.2; -. [Q9P2D8-2]
DR RefSeq; NP_065869.3; NM_020818.4. [Q9P2D8-2]
DR PDB; 7SX3; EM; 3.10 A; D=173-2635.
DR PDB; 7SX4; EM; 3.50 A; D=173-2635.
DR PDBsum; 7SX3; -.
DR PDBsum; 7SX4; -.
DR AlphaFoldDB; Q9P2D8; -.
DR SMR; Q9P2D8; -.
DR BioGRID; 121631; 7.
DR IntAct; Q9P2D8; 3.
DR STRING; 9606.ENSP00000256339; -.
DR TCDB; 1.A.1.11.15; the voltage-gated ion channel (vic) superfamily.
DR iPTMnet; Q9P2D8; -.
DR PhosphoSitePlus; Q9P2D8; -.
DR BioMuta; UNC79; -.
DR DMDM; 557952608; -.
DR EPD; Q9P2D8; -.
DR jPOST; Q9P2D8; -.
DR MassIVE; Q9P2D8; -.
DR PaxDb; Q9P2D8; -.
DR PeptideAtlas; Q9P2D8; -.
DR PRIDE; Q9P2D8; -.
DR ProteomicsDB; 6182; -.
DR ProteomicsDB; 83787; -. [Q9P2D8-1]
DR ProteomicsDB; 83788; -. [Q9P2D8-2]
DR ProteomicsDB; 83789; -. [Q9P2D8-3]
DR Antibodypedia; 77841; 32 antibodies from 8 providers.
DR DNASU; 57578; -.
DR Ensembl; ENST00000256339.8; ENSP00000256339.4; ENSG00000133958.13. [Q9P2D8-2]
DR Ensembl; ENST00000393151.6; ENSP00000376858.2; ENSG00000133958.13. [Q9P2D8-1]
DR Ensembl; ENST00000553484.5; ENSP00000451360.1; ENSG00000133958.13. [Q9P2D8-3]
DR Ensembl; ENST00000615108.1; ENSP00000479521.1; ENSG00000276416.3. [Q9P2D8-2]
DR Ensembl; ENST00000621021.1; ENSP00000480937.1; ENSG00000133958.13. [Q9P2D8-2]
DR Ensembl; ENST00000627404.2; ENSP00000487436.1; ENSG00000276416.3. [Q9P2D8-1]
DR Ensembl; ENST00000627695.2; ENSP00000485969.1; ENSG00000276416.3. [Q9P2D8-2]
DR Ensembl; ENST00000629588.2; ENSP00000486167.1; ENSG00000276416.3. [Q9P2D8-3]
DR GeneID; 57578; -.
DR KEGG; hsa:57578; -.
DR UCSC; uc001ybs.2; human. [Q9P2D8-1]
DR CTD; 57578; -.
DR DisGeNET; 57578; -.
DR GeneCards; UNC79; -.
DR HGNC; HGNC:19966; UNC79.
DR HPA; ENSG00000133958; Tissue enhanced (brain, pituitary gland).
DR neXtProt; NX_Q9P2D8; -.
DR OpenTargets; ENSG00000133958; -.
DR PharmGKB; PA134994003; -.
DR VEuPathDB; HostDB:ENSG00000133958; -.
DR eggNOG; KOG3685; Eukaryota.
DR eggNOG; KOG4820; Eukaryota.
DR GeneTree; ENSGT00390000011802; -.
DR InParanoid; Q9P2D8; -.
DR OMA; QGKEDQD; -.
DR OrthoDB; 81334at2759; -.
DR TreeFam; TF313437; -.
DR PathwayCommons; Q9P2D8; -.
DR Reactome; R-HSA-2672351; Stimuli-sensing channels.
DR SignaLink; Q9P2D8; -.
DR SIGNOR; Q9P2D8; -.
DR BioGRID-ORCS; 57578; 22 hits in 1073 CRISPR screens.
DR ChiTaRS; UNC79; human.
DR GenomeRNAi; 57578; -.
DR Pharos; Q9P2D8; Tbio.
DR PRO; PR:Q9P2D8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9P2D8; protein.
DR Bgee; ENSG00000133958; Expressed in right hemisphere of cerebellum and 79 other tissues.
DR ExpressionAtlas; Q9P2D8; baseline and differential.
DR Genevisible; Q9P2D8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024855; UNC79.
DR PANTHER; PTHR21696; PTHR21696; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..2635
FT /note="Protein unc-79 homolog"
FT /id="PRO_0000315618"
FT TRANSMEM 2223..2243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2466..2486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 907..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1693..1832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1929..1950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 754
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0KK59"
FT MOD_RES 758
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0KK59"
FT VAR_SEQ 1..177
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030583"
FT VAR_SEQ 1252
FT /note="R -> PMRLTRHEQSAPALGGTPEQTPG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10718198"
FT /id="VSP_030584"
FT VARIANT 1597
FT /note="V -> A (in dbSNP:rs28670114)"
FT /id="VAR_038260"
FT VARIANT 1670
FT /note="V -> I (in dbSNP:rs4905081)"
FT /evidence="ECO:0000269|PubMed:10718198"
FT /id="VAR_038261"
FT VARIANT 2183
FT /note="K -> R (in dbSNP:rs2296687)"
FT /id="VAR_038262"
FT VARIANT 2444
FT /note="G -> S (in dbSNP:rs7359096)"
FT /id="VAR_038263"
FT CONFLICT 494
FT /note="K -> R (in Ref. 2; BAC86131)"
FT /evidence="ECO:0000305"
FT CONFLICT 1284
FT /note="L -> P (in Ref. 2; BAC86131)"
FT /evidence="ECO:0000305"
FT HELIX 176..179
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 180..183
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 187..199
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 201..205
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 222..233
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 237..250
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 254..264
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 267..269
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 270..280
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 282..284
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 435..437
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 440..455
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 498..510
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 520..537
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 554..567
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 569..576
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 596..610
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 611..613
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 619..634
FT /evidence="ECO:0007829|PDB:7SX3"
FT TURN 638..641
FT /evidence="ECO:0007829|PDB:7SX4"
FT HELIX 644..651
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 652..655
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 663..666
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 668..671
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 672..674
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 675..677
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 679..694
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 701..715
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 797..815
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 826..840
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 860..878
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 951..963
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 969..983
FT /evidence="ECO:0007829|PDB:7SX3"
FT TURN 984..986
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 988..995
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 997..1006
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1008..1014
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1021..1035
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1040..1052
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1057..1072
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1076..1079
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1083..1099
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1105..1115
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1120..1136
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1138..1140
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1141..1154
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1163..1180
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1209..1219
FT /evidence="ECO:0007829|PDB:7SX3"
FT TURN 1221..1223
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1228..1231
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1273..1289
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1299..1315
FT /evidence="ECO:0007829|PDB:7SX3"
FT TURN 1320..1322
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 1325..1327
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1329..1334
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1336..1351
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1353..1371
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1376..1379
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 1380..1382
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1387..1389
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1392..1408
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 1414..1432
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2020..2036
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2038..2041
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2042..2044
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2045..2057
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2074..2089
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2090..2092
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2094..2099
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2108..2115
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 2120..2122
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2124..2137
FT /evidence="ECO:0007829|PDB:7SX3"
FT STRAND 2138..2140
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2145..2158
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2170..2181
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2182..2186
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2195..2205
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2210..2214
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2217..2230
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2235..2248
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2252..2270
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2278..2292
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2319..2324
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2325..2333
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2337..2342
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2357..2377
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2383..2387
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2389..2392
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2407..2428
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2441..2443
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2444..2457
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2471..2488
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2504..2526
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2531..2547
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2551..2565
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2576..2584
FT /evidence="ECO:0007829|PDB:7SX3"
FT HELIX 2605..2624
FT /evidence="ECO:0007829|PDB:7SX3"
SQ SEQUENCE 2635 AA; 295326 MW; 6ECB232BE0A4EA71 CRC64;
MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL SRTGKKENQD
ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY SVLRDAPSER GPQSRDAQLS
DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD LGQSIFYTTT CLLPFLNDDI LSTLPYTMIS
TLATFPPFLH KDIIEYLSTS FLPMAILGSS RREGVPAHVN LSASSMLMIA MQYTSNPVYH
CQLLECLMKY KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA
WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIA GDHSEWLIDV
LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP VRYCKRCHSN HHSNEVGAAA
ETHLYQTSPP PINTRECGAE ELVCAVEAVI SLLKEAEFHA EQREHELNRR RQLGLSSSHH
SLDNADFDNK DDDKHDQRLL SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM
MDDEVGSLVE KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL
KEGLNRILCL IPYNVINQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK MFDIELCPLP
FSMEEMFGFI SCRFTGYPSS VQEQALLWLH VLSELDIMVP LQLLISMFSD GVNSVKELAN
QRKSRVSELA GNLASRRVSV ASDPGRRVQH NMLSPFHSPF QSPFRSPLRS PFRSPFKNFG
HPGGRTIDFD CEDDEMNLNC FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ
APWGGSHTCQ KDEKAIECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS
RPEFIIGPEG EEEENPASKH GENPGNCTEP VEHAAVKNDT ERKFCYQQLP VTLRLIYTIF
QEMAKFEEPD ILFNMLNCLK ILCLHGECLY IARKDHPQFL AYIQDHMLIA SLWRVVKSEF
SQLSSLAVPL LLHALSLPHG ADIFWTIING NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT
KNHLLKYSLA HAFCCFLTAV EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD
RPTILSKLLL LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV
ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPVESKRA LSLPETLTSK IRQQSPENDN
TIKDLLPEDA GIDHQTVHQL ITVLMKFMAK DESSAESDIS SAKAFNTVKR HLYVLLGYDQ
QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ
QPPRCSLWSL KPHIRQMWLK ALLVILYKYP YRDCDISKIL LHLIHITVNT LNAQYHSCKP
HATAGPLYSD NSNISRYSEK EKGEIELAEY RETGALQDSL LHCVREESIP KKKLRSFKQK
SLDIGNADSL LFTLDEHRRK SCIDRCDIEK PPTQAAYIAQ RPNDPGRSRQ NSATRPDNSE
IPENPAMEGF PDARRPVIPE VRLNCMETFE VKVDSPVKPA PKEDLDLIDL SSDSTSGPEK
HSILSTSDSD SLVFEPLPPL RIVESDEEEE TMNQGDDGPS GKNAASSPSV PSHPSVLSLS
TAPLVQVSVE DCSKDFSSKD SGNNQSAGNT DSALITLEDP MDAEGSSKPE ELPEFSCGSP
LTLKQKRDLL QKSFALPEMS LDDHPDPGTE GEKPGELMPS SGAKTVLLKV PEDAENPTES
EKPDTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR EYLDISFNIL
DKLGEQKDPD PSTKGLSTLE MPRESSSAPT LDAGVPETSS HSSISTQYRQ MKRGSLGVLT
MSQLMKRQLE HQSSAPHNIS NWDTEQIQPG KRQCNVPTCL NPDLEGQPLR MRGATKSSLL
SAPSIVSMFV PAPEEFTDEQ PTVMTDKCHD CGAILEEYDE ETLGLAIVVL STFIHLSPDL
AAPLLLDIMQ SVGRLASSTT FSNQAESMMV PGNAAGVAKQ FLRCIFHQLA PNGIFPQLFQ
STIKDGTFLR TLASSLMDFN ELSSIAALSQ LLEGLNNKKN LPAGGAMIRC LENIATFMEA
LPMDSPSSLW TTISNQFQTF FAKLPCVLPL KCSLDSSLRI MICLLKIPST NATRSLLEPF
SKLLSFVIQN AVFTLAYLVE LCGLCYRAFT KERDKFYLSR SVVLELLQAL KLKSPLPDTN
LLLLVQFICA DAGTKLAEST ILSKQMIASV PGCGTAAMEC VRQYINEVLD FMADMHTLTK
LKSHMKTCSQ PLHEDTFGGH LKVGLAQIAA MDISRGNHRD NKAVIRYLPW LYHPPSAMQQ
GPKEFIECVS HIRLLSWLLL GSLTHNAVCP NASSPCLPIP LDAGSHVADH LIVILIGFPE
QSKTSVLHMC SLFHAFIFAQ LWTVYCEQSA VATNLQNQNE FSFTAILTAL EFWSRVTPSI
LQLMAHNKVM VEMVCLHVIS LMEALQECNS TIFVKLIPMW LPMIQSNIKH LSAGLQLRLQ
AIQNHVNHHS LRTLPGSGQS SAGLAALRKW LQCTQFKMAQ VEIQSSEAAS QFYPL
