UNC79_MOUSE
ID UNC79_MOUSE Reviewed; 2596 AA.
AC Q0KK59; Q0KK54; Q6L9U9; Q8CCC5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein unc-79 homolog;
GN Name=Unc79; Synonyms=Kiaa1409;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=BALB/cCrSlc; TISSUE=Brain;
RX PubMed=16807365; DOI=10.1096/fj.06-5952fje;
RA Nakayama M., Iida M., Koseki H., Ohara O.;
RT "A gene-targeting approach for functional characterization of KIAA genes
RT encoding extremely large proteins.";
RL FASEB J. 20:1718-1720(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 740-2596.
RC TISSUE=Brain;
RX PubMed=14680840; DOI=10.1016/j.bbrc.2003.10.193;
RA Nakayama M., Ohara O.;
RT "A system using convertible vectors for screening soluble recombinant
RT proteins produced in Escherichia coli from randomly fragmented cDNAs.";
RL Biochem. Biophys. Res. Commun. 312:825-830(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2123-2596.
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754 AND SER-758, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP INTERACTION WITH UNC80 AND NACLN, AND SUBUNIT.
RX PubMed=21040849; DOI=10.1016/j.neuron.2010.09.014;
RA Lu B., Zhang Q., Wang H., Wang Y., Nakayama M., Ren D.;
RT "Extracellular calcium controls background current and neuronal
RT excitability via an UNC79-UNC80-NALCN cation channel complex.";
RL Neuron 68:488-499(2010).
RN [6]
RP SUBUNIT, AND INTERACTION WITH UNC80.
RX PubMed=32620897; DOI=10.1038/s41467-020-17105-8;
RG C4RCD Research Group;
RA Wie J., Bharthur A., Wolfgang M., Narayanan V., Ramsey K., Aranda K.,
RA Zhang Q., Zhou Y., Ren D.;
RT "Intellectual disability-associated UNC80 mutations reveal inter-subunit
RT interaction and dendritic function of the NALCN channel complex.";
RL Nat. Commun. 11:3351-3351(2020).
CC -!- FUNCTION: Auxiliary subunit of the NALCN sodium channel complex. The
CC NALCN sodium channel complex is a voltage-gated ion channel responsible
CC for the resting Na(+) permeability that controls neuronal excitability.
CC Activated by neuropeptides substance P, neurotensin, and extracellular
CC calcium that regulates neuronal excitability by controlling the sizes
CC of NALCN-dependent sodium-leak current. {ECO:0000250|UniProtKB:Q8BLN6}.
CC -!- SUBUNIT: NALCN complex consists of NALCN and auxiliary subunits, UNC79,
CC UNC80 and NACL1. These auxiliary subunits are essential for the NALCN
CC channel function (By similarity). UNC80 bridges NALCN to UNC79
CC (PubMed:21040849). Interacts with NALCN (PubMed:21040849). Interacts
CC with UNC80 (PubMed:21040849,PubMed:32620897).
CC {ECO:0000250|UniProtKB:Q8BLN6, ECO:0000269|PubMed:21040849,
CC ECO:0000269|PubMed:32620897}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9P2D8};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the unc-79 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28287.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB257853; BAF03196.1; -; mRNA.
DR EMBL; AB257858; BAF03201.1; -; Genomic_DNA.
DR EMBL; AB093296; BAD02453.1; -; mRNA.
DR EMBL; AK033439; BAC28287.1; ALT_INIT; mRNA.
DR CCDS; CCDS49149.2; -.
DR RefSeq; NP_001074486.2; NM_001081017.2.
DR AlphaFoldDB; Q0KK59; -.
DR SMR; Q0KK59; -.
DR BioGRID; 229968; 5.
DR IntAct; Q0KK59; 1.
DR STRING; 10090.ENSMUSP00000136332; -.
DR iPTMnet; Q0KK59; -.
DR PhosphoSitePlus; Q0KK59; -.
DR EPD; Q0KK59; -.
DR MaxQB; Q0KK59; -.
DR PaxDb; Q0KK59; -.
DR PeptideAtlas; Q0KK59; -.
DR PRIDE; Q0KK59; -.
DR ProteomicsDB; 300094; -.
DR Antibodypedia; 77841; 32 antibodies from 8 providers.
DR Ensembl; ENSMUST00000101099; ENSMUSP00000098659; ENSMUSG00000021198.
DR GeneID; 217843; -.
DR KEGG; mmu:217843; -.
DR UCSC; uc007ouw.2; mouse.
DR CTD; 57578; -.
DR MGI; MGI:2684729; Unc79.
DR VEuPathDB; HostDB:ENSMUSG00000021198; -.
DR eggNOG; KOG3685; Eukaryota.
DR eggNOG; KOG4820; Eukaryota.
DR GeneTree; ENSGT00390000011802; -.
DR HOGENOM; CLU_000485_0_0_1; -.
DR InParanoid; Q0KK59; -.
DR OMA; QGKEDQD; -.
DR OrthoDB; 81334at2759; -.
DR PhylomeDB; Q0KK59; -.
DR Reactome; R-MMU-2672351; Stimuli-sensing channels.
DR BioGRID-ORCS; 217843; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Unc79; mouse.
DR PRO; PR:Q0KK59; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q0KK59; protein.
DR Bgee; ENSMUSG00000021198; Expressed in cortical plate and 42 other tissues.
DR ExpressionAtlas; Q0KK59; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030534; P:adult behavior; IMP:MGI.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI.
DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024855; UNC79.
DR PANTHER; PTHR21696; PTHR21696; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..2596
FT /note="Protein unc-79 homolog"
FT /id="PRO_0000315619"
FT TRANSMEM 2184..2204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2426..2446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 907..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1594..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1695..1832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1700..1717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1879..1909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 754
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 758
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 2596 AA; 290740 MW; 2FA26FC00CF5377B CRC64;
MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL SRTGKKENQD
ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY SVLRDAPSER GPQSRDAQLS
DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD LGQSIFYTTT CLLPFLNDDV LSTLPYTMIS
TLATFPPFLH KDIIEYLSTS FLPMAILGSS GREGVPAHVN LSASSMLMIA MQYTSNPVYH
CQLLECLMKY KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA
WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIS GDHSEWLIDV
LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP VRYCKRCHSN HHSNEVGATA
ETHLYQTSPP PINTRECGAE ELVCAVEAVI SLLKEAEFHA EQREHELNRR RQLGLSSSHH
SLDNTDFDNK DDDKHDQRLL SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM
MDDEVGSLVE KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL
KEGLNRILCL IPYNVISQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK MFDIELCPLP
FSMEEMFGFI SCRFTGYPST VQEQALLWLH VLSELDITVP LQLLISMFSD GVNSVKELAN
QRKSRANELA GNLASRRVSV ASDPGRRGQH NTLSPFHSPF QSPFRSPMRS PFRSPFKNFG
HPGGRTIDFD CEDDDMNLNC FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ
APWGGSHSCQ KDKKATECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS
RPEFILGPEG EEEENPAAKH GENPGNRTVP SEHAAIKNDT ERKFCYQQLP VTLRLIYTIF
QEMAKFEEPD ILFNMLNCLK ILCLHGECLY TARKDHPQFL AYIQDHMLIA SLWRVVKSEF
SQLSSLAVPL LLHALSLPHG ADIFWTIING NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT
KNHLLKYSLA HAFCCFLTAV EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD
RPTILSKLLL LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV
ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPAESKRA LSLPETLTSK IRQQSPENDN
TIKDLLPEDA GIDHQTVHQL ITVLMKFMAR DESSAESDIS SAKAFNTVKR HLYVLLGYDQ
QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ
QPPRCSLWSL KPHIRQMWLK ALLVILYKYP YRDCDVSKTL LHLIHITVNT LNAQYHSCKP
HATAGPLYTD NSNISRYSEK EKGEIELAEY RETGALQDSV LHCVREESIQ KKKLRSLKQK
SLDIGNADSL LFTLDEHRRK SCIDRCDIDK PPAQAAYISQ RQNDHHGRSR QNSATRPDNT
EIPKNPGTEG FQEIRRPVIP EVRLNCMETF EVRVDSPGKP APREDLDLID LSSDSTSGPE
KHSILSTSDS DSLVFEPLPP LRIVESDEEE EMMNQGNGGA LGNNAASSPS IPSQPSVLSL
STTPLVQVSV EDCSKDFSSK DSGNHQSASN EDSTIAALDD LTDSEELSKS EELREFASGS
PLTLKQKRDL LQKSSAVPEM SVDYNPEPSP AEEKPGQTPT SGVKTVLLKV PEDGENLIES
EKPNTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR EYLDISFNIL
DKLGEQKDPD PSAKGLSTLE MPRESSSAPT LEAGAPETSS HSSISKQIQP GKRQCNVPMC
LNPDLEGQPL RTRGATKSSL LSAPSIASMF VPAPEEFTEE QPTVMADKCH DCGAILEEYD
EETLGLAIVV LSTFIHLSPD LAAPLLLDIM QSVGRLASST TFSNQAESMM VPGNAAGVAK
QFLRCIFHQL APNGIFPQLF QSAIKDGTFL RTLATSLMDF NELSSIAALS QLLEGLNNKK
NLPAGGAMIR CLENIATFME ALPMDSPSSL WTTISNQFQT FFAKLPCVLP LKCSLDSSLR
IMICLLKIPS TNATRSLLEP FSKLLSFVIQ NAVFTLAYLV ELCGLCYRAF TKERDKFYLS
RSVVLELLQA LKLKSPLPDT NLLLLVQFIC ADAGTKLAES TILSKQMIAS VPGCGTAAME
CIRQYVSEVL EFMADMHTLT KLKSHMKTCS QPLHEDTFGG HLKVGLAQIA AMEISRGNHR
DNKAVIRYLP WLYHPPSAMQ QGPKEFIECV SHIRLLSWLL LGSLTHNAVC PNASSPCLPI
PLDAGSHIAD HLIVILIGFP EQSKTCVLHM CSLFHAFIFA QLWTVYCEQS AVATNVQNQN
EFSFTAILTA LEFWSRVTPS ILQLMAHNKV MVEMVCLHVI SLMEALQECN STIFVKLIPM
WLPMIQSNTK HLSAGLQLRL QAIQNNVNHH SLRTLPGSGQ SSAGLAALRK WLQCTQFKMA
QVEIQSSEAA SQFYPL
