UNC80_DROME
ID UNC80_DROME Reviewed; 3303 AA.
AC Q9VB11;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2015, sequence version 5.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein unc-80 homolog;
GN Name=unc80 {ECO:0000312|FlyBase:FBgn0039536};
GN ORFNames=CG18437 {ECO:0000312|FlyBase:FBgn0039536};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=17350263; DOI=10.1016/j.cub.2007.02.037;
RA Humphrey J.A., Hamming K.S., Thacker C.M., Scott R.L., Sedensky M.M.,
RA Snutch T.P., Morgan P.G., Nash H.A.;
RT "A putative cation channel and its novel regulator: cross-species
RT conservation of effects on general anesthesia.";
RL Curr. Biol. 17:624-629(2007).
RN [4]
RP FUNCTION, INTERACTION WITH UNC79 AND NA, AND DISRUPTION PHENOTYPE.
RX PubMed=24223770; DOI=10.1371/journal.pone.0078147;
RA Lear B.C., Darrah E.J., Aldrich B.T., Gebre S., Scott R.L., Nash H.A.,
RA Allada R.;
RT "UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion
RT channel, are indispensable for robust circadian locomotor rhythms in
RT Drosophila.";
RL PLoS ONE 8:E78147-E78147(2013).
CC -!- FUNCTION: Component of the na (narrow abdomen) sodium channel complex.
CC In the circadian clock neurons it functions with na and unc79 to
CC promote circadian rhythmicity. {ECO:0000269|PubMed:24223770}.
CC -!- SUBUNIT: Interacts with unc79 and na. Can interact with unc79
CC independently of na. {ECO:0000269|PubMed:24223770}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Severe disruptions in circadian rhythmicity.
CC Decreases anticipatory behaviors and free-running rhythmicity. RNAi-
CC mediated knockdown in pacemaker neurons decreases anticipatory
CC behaviors under constant dark (DD) conditions but has no effect on
CC light-dark (LD) rhythmic behavior. {ECO:0000269|PubMed:24223770}.
CC -!- SIMILARITY: Belongs to the unc-80 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF56734.5; -; Genomic_DNA.
DR RefSeq; NP_651577.4; NM_143320.4.
DR SMR; Q9VB11; -.
DR BioGRID; 68206; 3.
DR IntAct; Q9VB11; 4.
DR STRING; 7227.FBpp0303144; -.
DR PaxDb; Q9VB11; -.
DR PRIDE; Q9VB11; -.
DR EnsemblMetazoa; FBtr0330108; FBpp0303141; FBgn0039536.
DR GeneID; 43324; -.
DR KEGG; dme:Dmel_CG18437; -.
DR UCSC; CG18437-RB; d. melanogaster.
DR CTD; 285175; -.
DR FlyBase; FBgn0039536; unc80.
DR VEuPathDB; VectorBase:FBgn0039536; -.
DR eggNOG; ENOG502QSTP; Eukaryota.
DR GeneTree; ENSGT00640000091496; -.
DR InParanoid; Q9VB11; -.
DR Reactome; R-DME-2672351; Stimuli-sensing channels.
DR BioGRID-ORCS; 43324; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43324; -.
DR PRO; PR:Q9VB11; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039536; Expressed in brain and 5 other tissues.
DR ExpressionAtlas; Q9VB11; baseline and differential.
DR Genevisible; Q9VB11; DM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0034703; C:cation channel complex; ISS:UniProtKB.
DR GO; GO:0005261; F:cation channel activity; ISS:UniProtKB.
DR GO; GO:0055080; P:cation homeostasis; ISS:UniProtKB.
DR GO; GO:0045475; P:locomotor rhythm; IMP:FlyBase.
DR InterPro; IPR045852; UNC80.
DR InterPro; IPR031542; UNC80_N.
DR Pfam; PF19424; UNC80; 4.
DR Pfam; PF15778; UNC80_N; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..3303
FT /note="Protein unc-80 homolog"
FT /id="PRO_0000367809"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1969..1989
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2018..2038
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2048..2068
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2518..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3003..3158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3170..3262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2523..2538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3017..3110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3140..3155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3170..3189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3222..3262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3303 AA; 367919 MW; 08CEFCF686F3635D CRC64;
MVTNAAGTAA TGGATSNTTN NNNLQTNNNS HGANNNNDDF DFDQDSGLQD LGLPVSVQTF
LWRQIAPFIR PKLGKLHEST CLFCQHAPGH HESKEACKSF EKVLVQNIQF GLSPPLTKGL
GVIPRWRLLQ GALPHVMHAC AALLYNRVKD MQAIGPVETK LLYTMQWILL YAAEECADDE
GGEDLGLGDA AEPKSKSIDQ YLFSVPTITL FVYLFAPIIH HLKESDFQNF RLENGIKLWQ
GMWDNRAPGA PCFTAPVKPK ARNLLCAPTP KGSTDVFPAR KHSLSADAMS PKADSPQSGI
SDYGRQDEEG SWVSSPKEFA FPETIPEEAS SVEDERVVIF RLPSAPQLMD NSFFTADASL
LQQQQSQSRR GSRQSMNSRD KDKVPSTKFE FDQQELMRGA SMKEKRSASI EKETDSDKSE
SIKADVSAAT FLDVAVLRCL FISHWQEEGI FWSLQYLYNR LSDIGEEAAI TLNQPRKRSN
SLPIPQIEIS LYQGPGSNSR DSPGSSVVKD YIEIPDPSPT VTACVAEEPQ SAPSTTERRG
SEKKKRVKMA DLRAFVETKM FSKSEKNLEK VGLDTNSANG KTPLQHAEYH RSLDTGEKKL
SRSASMISRE PASNLIKGKS MPSLRFYRYV EPPKAPRPSQ ATCPRSTAFY PRNPIITVTE
HTPTPSPDYM KRQGSIDSQL DALSNGGSIA GMTGNGGGNG STGMGSSTTR YRGQMLRSHT
DSHIDYTGVD ESEAPGSSFY ITRDGGIDYE IILLAISNVF KRDPAQVCSL RVLEAGLNIC
ELLIEMGVLK LGEHAHEISM SITRRALQVL GCPHGCNDGV RGPPADFLRN QCQKILSRML
RQAGQRTKRF MQEMVKTSPL PELIDYFHAF LAFCVDPSSL LSPLSQGGYS TNFSGGMSGG
AEAQVVGAVF KPLVSRFVEA SKDLKGPENI ALYGDIRQLV TYVKGAHGGP FRLVALSGIL
AVTPRPHKKG PSAQTTRVIR HIPQANANQS LQNDDNRSQR RLLLKKRSTS SACASLLETE
ACEEHYKTSQ SPLSNFRRRT TGVRPTLTPR HSERALLSDS TSSSERNSLG RLSGLVRWFR
GTPKEASSID LEIGSLNPEI SSTFMRHASL KIQRGRSSDG IGRSIQRAKR RVERRLNRFG
GIVKGKKKVG GIEETADFSR RSSSDMCDGP RESEVVILKE RKLVPTEPVR VGMLRLSFLL
ETCAPGSFPD PQLVAAVLDL PQAPLVARAT FLLECAHFVH LCNKGQWPAW MKQNVGSYRA
SGANINLNQM KQQVSQTSAR RTHILQRAAG KMFHQWAEMV GARLEEILFT ERLQYEAVNA
SLTDPEKQRE LLQQDEEEDF LDETSVNPHG NDCPHSLKLI ACVLLFEITA FLRDTYLMLP
KTSKLIHRDK PAPWEKVYRE ANRRWSMALS SMGHSQTSAQ SLQSIAAGND GAGQSERKIS
FVLHEPDNES ENSSNTTLTK EGEEARRPTT SAVRPFLLRR GTATTTGGSF KRRSLKLRRN
TKDSKDIETD FNMQSRRKVS SLSDRSDTSE QGMISGGEES PGILSDDQQP ESPTDSNEND
DTAKNMPWLK AIIDLMSSYN YYCTHKGYCH PFCYKRHMRS CTRLVKATRK VYGEEFGFTF
DADHPNVEPT IITSSKPHTS RARSTRKVSE QSSTQTSPSK RKDSLSRKDR ISDDPDLEMA
EKLAKAFRQE KEKKMQEEPP ILKFIRIHIR NLFHFPLATL LKGAVVLTEE MVIEAMPAAW
ELLLETNHDT ATSSAAVFLM GSVKAQNFAF DIMQRALKHK DPDIRIGAIQ RYLVLWKCRF
HVWPRMEENA HDVTFKVPPG GIEFTLPSPK IGIESLPVVD PPWMPVQQTK DMDVTLNQDR
HRSLVTATKS RKMQQTEAIR NALRQQRDKQ RAERHSFLIT MIPISQQASH EPGMEKLEDH
EIEEDLDGTR MSSHLHHAHS LFPSVLCSSV MQIVGCLDDA AIGSDGNAVY EIAYQVIWVC
LVEESALFLR YVFERLTRDR QDQMFKLLRH LIRFVPRLPQ QAAFALYNSI IGYIMFYVRS
SNELKQELVG SALSVLWMVV HSVHGIMFKD LKQILRKEQC DASILLTANV PAAKKIVVHG
PADDDYNIPS QFPVQEDTLF CQLLKEALDY YPIDEKNTSH YCLVDYKSSK ILNPNWYIRD
LYFFKRSQYP EVRLMLMRPE ESFLALQKQE LTKKFVEIGK VHLTWAILKN VDMVVQRVVF
LHEELMKLPS FPRKALEVDL DLHHGGEYGK VLLGLDVLHK FMWVRLIARM FEAMAGNFAY
SADIQLFLNV LSGASILHAE DSCIMRYVMA TFINAAFNFK NIFSTNGYFM IMPTLLQVYS
LHQTNKLITT TIEYAVKQFY LLNRKPFILQ MFGSVSAILD TDEDGTYGEA HKVQSSCLFN
LLLSLEDPSP DPLNIAELVK EPKPLKAIDF CYHDEDDDVT VLDCITLCVM VVSYSAESTR
GYQMLIILEA ILPCYLQQIQ SPSYIPLQGK SERDIILQLA VAIRTMVHNC EGLAKSYNGP
YRNSPEHKGS SQRNCSRGPP CSPGLDFEEE THPKYMTDAR TKNMMDSAED SEMIRTEYRR
PRDVLLSVVA DFLTKSTVRL AELAKKMPSD TKPTEVLDAK CHIRLADIAH SLLKVSPYDP
ESMACRGLQR YMQAVLPRAE WSNDTLRNAL VTILRRIDKV FLKISKKPSI RRNTDWEAAA
GLLKGIHETI IRHSYVLHWQ QMKTLISTVQ NLIVNEPGIP EGVSSAGAAL MSQNPPAFFC
SAVVRLVALQ VVSPVDCFSL VQICGGSSEF ATQEKAEGFL MHLIMPLCLK VCSGRGVSDV
GELKMSDVSF LLTAVLNAMS PPAGRTGQAV SQINRVTGDL RAGSLTFTGS RDAKRPARIS
GSLYQAAFLA LRIVCICFES RLSNEWPRIV RVMRDLGRRN EAAPDLWSFM EFVVTHRTPL
YIVLLPFILH KISQPPIGDH ERHMQFIIRE RLRGTPPQGG IKSKGALLLE LARELRDLRD
ELEEKRYDRE SSEQKKSDTP AATSAAEAHK SQQRPSLISI FTGTTTGQAS HSHVSAVPID
SRSGSGGICT PSDTLSQQTL HPPRESLSSS STGRDPHTTT SESQSGEADA GSAPTLVGAT
PSGSGHGSGG GIGTGAASAV PSHLSHSQSL QQAPFKAQPP KLRFVSSVEF RHSSGETSTT
PLSPESPAED SSGDHTRSRL QRSKAASRKT FRLKRSRLTP MEPPSIVTSQ EEQAPQAQAK
TLGEISWDSV SQTSSTSGYR DNNSLQTGLL SPDGSLGGLT LGRSPSQHSL LMVFEGQDED
TLI
