UNC8_CAEEL
ID UNC8_CAEEL Reviewed; 777 AA.
AC Q21974;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Degenerin unc-8;
DE AltName: Full=Uncoordinated protein 8;
GN Name=unc-8; ORFNames=R13A1.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RA Tavernarakis N., Shreffler W., Wang S.L., Driscoll M.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000305}.
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DR EMBL; U76402; AAB39734.1; -; mRNA.
DR EMBL; FO080842; CCD67152.1; -; Genomic_DNA.
DR PIR; T16737; T16737.
DR RefSeq; NP_501138.1; NM_068737.1.
DR AlphaFoldDB; Q21974; -.
DR BioGRID; 42613; 1.
DR STRING; 6239.R13A1.4c; -.
DR TCDB; 1.A.6.2.4; the epithelial na(+) channel (enac) family.
DR PaxDb; Q21974; -.
DR EnsemblMetazoa; R13A1.4a.1; R13A1.4a.1; WBGene00006748.
DR GeneID; 177494; -.
DR UCSC; R13A1.4; c. elegans.
DR CTD; 177494; -.
DR WormBase; R13A1.4a; CE26381; WBGene00006748; unc-8.
DR eggNOG; KOG4294; Eukaryota.
DR InParanoid; Q21974; -.
DR PhylomeDB; Q21974; -.
DR PRO; PR:Q21974; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006748; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q21974; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IC:WormBase.
DR GO; GO:0005261; F:cation channel activity; ISS:WormBase.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; ISS:WormBase.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004726; Deg-1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690; PTHR11690; 2.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR TIGRFAMs; TIGR00867; deg-1; 1.
DR PROSITE; PS01206; ASC; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium channel; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..777
FT /note="Degenerin unc-8"
FT /id="PRO_0000181289"
FT TOPO_DOM 1..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..689
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 711..777
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 752..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 411
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 533
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 597
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 777 AA; 89128 MW; 9B328C3A24A1E7E6 CRC64;
MSPLLTWNLI CVSSRWYTIL CLKNKVKFWL GTRLVHEPES MESRSSPYIR PSPYAGGVHP
HFEEEDDRSK LHASALYSER RTSSRKSLRS QKIDYHTTTI KSLWFDFCAR TSSHGIPYVA
TSSFFGRYVW AALFMCMLMA FLLQTYWTMS EYLQYRTIIE MQLQFEAAAF PAATVCNLNA
FKYSELTQYE EIKEGFDYWE RVINARMMSD SMKPGGDILE AISVRKKRSK SRDQLLFPID
DEDLEGAVYQ PVFVRCTCMN MEQCVPNRNP LEVNASICMC FEDVTRGLIW PCYPTSVWTV
KKCSGCSISN TCPDPDGPNA SKQIAKHNSP LPCLCQSISH HCMVHPKDEI RWWNPNNYTV
YSVTEPPTTE ITETEEAFGL SDLKDAGAIT TQTKENLIFL VAALPRETRR NLSYTLNEFV
LRCSFNSKDC SMERDFKLHV DPEYGNCYTF NFNDSVELKN SRAGPMYGLR LLLNVHQSDY
MPTTEAAGVR LVVHEQDQEP FPDTFGYSAP TGFISSFGLK TKELHRLSAP WGNCSDTFRP
VPYIYNEHYS PEGCHRNCFQ LKVLEICGCG DPRFPLPSEE HRHCNAKSKI DRQCLSNLTS
DSGGYHHLHE QCECRQPCHE KVFETAYSAS AWPSQNFKIG TDCPAVSDIF NDTEACTEYY
RQNTAYIEIY YEQLNFESLK ETAGYTLVNL FSDFGGNIGL WIGFSVITFA EFAELFCEIC
KLMYFKGIVY VQKKMQGKEY TSSSLMHIDF LQRSPKKSQP GEDEVSTNES TKELMSK
