UNC98_CAEBR
ID UNC98_CAEBR Reviewed; 308 AA.
AC Q612G6; A8XPQ2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc finger protein unc-98;
DE AltName: Full=Uncoordinated protein 98;
GN Name=unc-98 {ECO:0000250|UniProtKB:Q19203}; ORFNames=CBG16732;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Probable transcription factor. Required for muscle structure.
CC Its dual subcellular localization suggests that it may function both as
CC a muscle adhesion complex protein and as a transcription factor, or
CC work together with transcription factors, to influence gene expression.
CC Thought to act as a molecular bridge between unc-97 and mhc-a at the M-
CC line of muscles, possibly in a signaling role (By similarity).
CC {ECO:0000250|UniProtKB:Q19203}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q19203}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q19203}. Note=Localized in body wall muscle M-
CC lines, dense bodies and muscle nuclei. {ECO:0000250|UniProtKB:Q19203}.
CC -!- DOMAIN: The N-terminal part (1-106) mediates the nuclear localization,
CC while the fourth zinc finger is required for the localization to M-
CC lines and dense bodies. {ECO:0000250|UniProtKB:Q19203}.
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DR EMBL; HE600942; CAP34628.1; -; Genomic_DNA.
DR RefSeq; XP_002645070.1; XM_002645024.1.
DR AlphaFoldDB; Q612G6; -.
DR STRING; 6238.CBG16732; -.
DR EnsemblMetazoa; CBG16732.1; CBG16732.1; WBGene00036597.
DR GeneID; 8587068; -.
DR KEGG; cbr:CBG_16732; -.
DR CTD; 8587068; -.
DR WormBase; CBG16732; CBP18808; WBGene00036597; Cbr-unc-98.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_078605_0_0_1; -.
DR InParanoid; Q612G6; -.
DR OMA; HERIHDV; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000008549; Chromosome X.
DR GO; GO:0031430; C:M band; ISS:UniProtKB.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0040011; P:locomotion; ISS:UniProtKB.
DR GO; GO:0007626; P:locomotory behavior; ISS:UniProtKB.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0030239; P:myofibril assembly; ISS:UniProtKB.
DR GO; GO:0040032; P:post-embryonic body morphogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Muscle protein; Myogenesis; Nucleus; Reference proteome;
KW Repeat; Thick filament; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..308
FT /note="Zinc finger protein unc-98"
FT /id="PRO_0000306200"
FT ZN_FING 111..133
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 139..161
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 166..186
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q19203,
FT ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..266
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 308 AA; 34999 MW; 68354B18F92EEF8C CRC64;
MGDDLFKEAR KERDDFEELM NACDLAKMSV KNNEMVHGLE TFGVNHGESS SENKPTEIMK
VVAPTVEAYV GSSSSTTVTK PSGGAVDGID QKEVRQDGTS VQKDDNGFIF YKCRFCGLTF
NFMNTLRAHE RIHDVSQPYV CGKCGESYEF ACQLEYHAAQ HSEIDGFKCD CGRTFFSYTE
MLYHKHTDDP IELIGAPETT TVLVNKKKII PVTEQDLPQP AFVTEGYEPK HPLRVYSDVR
SKPYICEYCS KSYSDSRGLA YHMYSHRGEK QFNPRASRYM MGREGVGYTD SRSYYLFPRT
SGYVSPRF
