ID   UNGI_ARATH              Reviewed;         170 AA.
AC   Q9SI87;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable inactive uracil-DNA glycosylase, mitochondrial {ECO:0000303|PubMed:20056608};
DE   Flags: Precursor;
GN   OrderedLocusNames=At2g10550 {ECO:0000312|Araport:AT2G10550};
GN   ORFNames=T4D8.4 {ECO:0000312|EMBL:AAD28673.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION.
RX   PubMed=20056608; DOI=10.1074/jbc.m109.067173;
RA   Cordoba-Canero D., Dubois E., Ariza R.R., Doutriaux M.P., Roldan-Arjona T.;
RT   "Arabidopsis uracil DNA glycosylase (UNG) is required for base excision
RT   repair of uracil and increases plant sensitivity to 5-fluorouracil.";
RL   J. Biol. Chem. 285:7475-7483(2010).
CC   -!- FUNCTION: Probable inactive paralog of AtUNG (AC Q9LIH6) generated by a
CC       gene duplication event and subsequently disrupted by at least two
CC       transposon insertions. {ECO:0000269|PubMed:20056608}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC       UNG family. {ECO:0000305}.
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DR   EMBL; AC007188; AAD28673.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06148.1; -; Genomic_DNA.
DR   PIR; C84492; C84492.
DR   RefSeq; NP_178849.1; NM_126808.1.
DR   AlphaFoldDB; Q9SI87; -.
DR   STRING; 3702.AT2G10550.1; -.
DR   iPTMnet; Q9SI87; -.
DR   PaxDb; Q9SI87; -.
DR   PRIDE; Q9SI87; -.
DR   EnsemblPlants; AT2G10550.1; AT2G10550.1; AT2G10550.
DR   GeneID; 815515; -.
DR   Gramene; AT2G10550.1; AT2G10550.1; AT2G10550.
DR   KEGG; ath:AT2G10550; -.
DR   Araport; AT2G10550; -.
DR   TAIR; locus:2063555; AT2G10550.
DR   HOGENOM; CLU_1572796_0_0_1; -.
DR   OrthoDB; 832568at2759; -.
DR   PhylomeDB; Q9SI87; -.
DR   PRO; PR:Q9SI87; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004844; F:uracil DNA N-glycosylase activity; IBA:GO_Central.
DR   GO; GO:0097510; P:base-excision repair, AP site formation via deaminated base removal; IBA:GO_Central.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..53
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           54..170
FT                   /note="Probable inactive uracil-DNA glycosylase,
FT                   mitochondrial"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000433480"
SQ   SEQUENCE   170 AA;  18494 MW;  EA3FD2CBFC187BDF CRC64;
     MALSTPKTLM DFFQPAKRLK ASPSSSSSFP AVSVAGRSRD LGSVANSPPR VTVTTAVADD
     SSGLTPEQVA RAEFHKFVAK SKSNLAVCSV KVTKAKGLIL IMDLVKLWVY PSMCLKEKSP
     SSLLNIFKEL HKDVGDKLHM VYFRRNKKEN VSHVTSLAVE DVTGITRTKG