ID   CA1A_CONVE              Reviewed;          17 AA.
AC   P0C8V4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Alpha-conotoxin-like Vn {ECO:0000303|PubMed:18266261};
DE   AltName: Full=Vn1A {ECO:0000305};
OS   Conus ventricosus (Mediterranean cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lautoconus.
OX   NCBI_TaxID=117992;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT CYS-17, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=18266261; DOI=10.1002/jssc.200700448;
RA   Romeo C., Di Francesco L., Oliverio M., Palazzo P., Massilia G.R.,
RA   Ascenzi P., Polticelli F., Schinina M.E.;
RT   "Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in
RT   the intraspecific variation.";
RL   J. Sep. Sci. 31:488-498(2008).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18266261}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:18266261}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C8V4; -.
DR   ConoServer; 3712; Vn1A.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..17
FT                   /note="Alpha-conotoxin-like Vn"
FT                   /id="PRO_0000366082"
FT   REGION          5..7
FT                   /note="Ser-Xaa-Pro motif, crucial for potent interaction
FT                   with nAChR"
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
FT   MOD_RES         17
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:18266261"
FT   DISULFID        3..9
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
FT   DISULFID        4..17
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
SQ   SEQUENCE   17 AA;  1723 MW;  76F7F3995FD87F15 CRC64;
     GGCCSYPPCA VSNPQHC