ID   CA1CB_CONTE             Reviewed;          62 AA.
AC   P0DPL8;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Conotoxin TxIC {ECO:0000305};
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   McIntosh J.M., Olivera B.M., Cruz L.J., Corpuz G.P., Jones R.M.,
RA   Garrett J.E.;
RT   "Conotoxin peptides.";
RL   Patent number US6767896, 27-JUL-2004.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, HYDROXYLATION AT
RP   PRO-60, AND AMIDATION AT CYS-61.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22709442}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/2 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DPL8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR031565; T-conotoxin.
DR   Pfam; PF16981; Chi-conotoxin; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW   Hydroxylation; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..47
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000445054"
FT   PEPTIDE         48..61
FT                   /note="Conotoxin TxIC"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000445055"
FT   MOD_RES         60
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         61
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        52..58
FT                   /evidence="ECO:0000250|UniProtKB:P0C1D0"
FT   DISULFID        53..61
FT                   /evidence="ECO:0000250|UniProtKB:P0C1D0"
SQ   SEQUENCE   62 AA;  6879 MW;  7EDDA285C044FAAA CRC64;
     MHCLPIFVIL LLLTASGPSV DAQLKTKDDV PLSSFRDHAK STLRRLQDKQ TCCGYRMCVP
     CG