ID   CA1C_CONAL              Reviewed;          16 AA.
AC   P56641;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Alpha-conotoxin AuIC;
OS   Conus aulicus (Princely cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
OX   NCBI_TaxID=89437;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, AMIDATION AT CYS-16, MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=9786965; DOI=10.1523/jneurosci.18-21-08571.1998;
RA   Luo S., Kulak J.M., Cartier G.E., Jacobsen R.B., Yoshikami D.,
RA   Olivera B.M., McIntosh J.M.;
RT   "Alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic
RT   acetylcholine receptors and nicotine-evoked norepinephrine release.";
RL   J. Neurosci. 18:8571-8579(1998).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       This toxin blocks mammalian nAChR alpha-3/beta-4 subunits.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9786965}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:9786965}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1667.6; Method=LSI;
CC       Evidence={ECO:0000269|PubMed:9786965};
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   PIR; C59045; C59045.
DR   AlphaFoldDB; P56641; -.
DR   ConoServer; 407; AuIC.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018072; Conotoxin_a-typ_CS.
DR   PROSITE; PS60014; ALPHA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Alpha-conotoxin AuIC"
FT                   /evidence="ECO:0000269|PubMed:9786965"
FT                   /id="PRO_0000044456"
FT   REGION          4..6
FT                   /note="Ser-Xaa-Pro motif, crucial for potent interaction
FT                   with nAChR"
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
FT   MOD_RES         16
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:9786965"
FT   DISULFID        2..8
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
FT   DISULFID        3..16
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
SQ   SEQUENCE   16 AA;  1673 MW;  1E310D3B8FDC7001 CRC64;
     GCCSYPPCFA TNSGYC