UNG_MIMIV
ID UNG_MIMIV Reviewed; 370 AA.
AC Q5UPT2;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Probable uracil-DNA glycosylase;
DE Short=UDG;
DE EC=3.2.2.-;
GN Name=UNG; OrderedLocusNames=MIMI_L249;
OS Acanthamoeba polyphaga mimivirus (APMV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Imitervirales; Mimiviridae; Mimivirus.
OX NCBI_TaxID=212035;
OH NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rowbotham-Bradford;
RX PubMed=15486256; DOI=10.1126/science.1101485;
RA Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA La Scola B., Susan M., Claverie J.-M.;
RT "The 1.2-megabase genome sequence of Mimivirus.";
RL Science 306:1344-1350(2004).
CC -!- FUNCTION: Excises uracil residues from the DNA which can arise as a
CC result of misincorporation of dUMP residues by DNA polymerase or due to
CC deamination of cytosine. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC UNG family. {ECO:0000305}.
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DR EMBL; AY653733; AAV50521.1; -; Genomic_DNA.
DR RefSeq; YP_003986745.1; NC_014649.1.
DR PDB; 5X55; X-ray; 2.30 A; A/B=1-370.
DR PDB; 6LYD; X-ray; 2.60 A; A=95-370.
DR PDB; 6LYE; X-ray; 3.10 A; A=95-370.
DR PDBsum; 5X55; -.
DR PDBsum; 6LYD; -.
DR PDBsum; 6LYE; -.
DR SMR; Q5UPT2; -.
DR GeneID; 9924856; -.
DR KEGG; vg:9924856; -.
DR Proteomes; UP000001134; Genome.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd10027; UDG-F1-like; 1.
DR DisProt; DP01481; -.
DR Gene3D; 3.40.470.10; -; 1.
DR InterPro; IPR002043; UDG_fam1.
DR InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR11264; PTHR11264; 1.
DR Pfam; PF03167; UDG; 1.
DR SUPFAM; SSF52141; SSF52141; 1.
DR PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA repair; Hydrolase; Reference proteome.
FT CHAIN 1..370
FT /note="Probable uracil-DNA glycosylase"
FT /id="PRO_0000176176"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 191
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10072"
FT HELIX 98..102
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 114..117
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 119..121
FT /evidence="ECO:0007829|PDB:6LYD"
FT HELIX 125..128
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 132..134
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 135..142
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 146..159
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 164..166
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 168..170
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 173..177
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 180..182
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 185..191
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 206..209
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 219..230
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 244..248
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 251..257
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 264..266
FT /evidence="ECO:0007829|PDB:5X55"
FT TURN 267..272
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 273..286
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 291..296
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 297..303
FT /evidence="ECO:0007829|PDB:5X55"
FT TURN 308..310
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 311..316
FT /evidence="ECO:0007829|PDB:5X55"
FT TURN 321..325
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 328..332
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 334..336
FT /evidence="ECO:0007829|PDB:5X55"
FT STRAND 338..342
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 345..347
FT /evidence="ECO:0007829|PDB:5X55"
FT HELIX 350..360
FT /evidence="ECO:0007829|PDB:5X55"
SQ SEQUENCE 370 AA; 42218 MW; 15D0E0CF1DB11A26 CRC64;
MSKKNVDPFS DSDSSSEPPS IFSSDNEENS DVDNSVIIND KNTKSDEADI KYMDEDESSD
SESESESKKK SKKSKKSKKS KKSVTKKKNN LLVGNRIITE YILIDANNYH FKSWIECFPD
CKVNLKLLLF RPEWFDFFKY VESKTYFPQL ESKLSSYLEK RQRIVPYPEL LFNTMNVLPP
GKIKVVILGQ DPYPGSCISG VPYAMGCSFS VPLNCPVPKS LANIYTNLIK FNHMRKAPKH
GCLASWILQG TFMINSAFTT VLNESGVHAR TWESFTADLI DYLTDNYDDL IFVAWGAHAH
KLCQRVDPKK HYIITSSHPS PYSVSNTMTS MSYGPNPKKV TYPSFNSVDH FGKINEHLKS
RNKKPIFWDL
