ID   CA1E_CONCN              Reviewed;          61 AA.
AC   P0DKP7;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Alpha-conotoxin CnIJ;
DE   Contains:
DE     RecName: Full=Alpha-conotoxin CnIE;
DE   Flags: Precursor;
OS   Conus consors (Singed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=101297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT CYS-59, MASS SPECTROMETRY,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=22705119; DOI=10.1016/j.jprot.2012.06.001;
RA   Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F.,
RA   Stocklin R., Favreau P.;
RT   "Large-scale discovery of conopeptides and conoproteins in the injectable
RT   venom of a fish-hunting cone snail using a combined proteomic and
RT   transcriptomic approach.";
RL   J. Proteomics 75:5215-5225(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22705119}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22705119}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha3/6 pattern.
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Alpha-conotoxin CnIJ]: Mass=1623.66;
CC       Method=Electrospray; Note=CnIJ.;
CC       Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MASS SPECTROMETRY: [Alpha-conotoxin CnIE]: Mass=1410.56;
CC       Method=Electrospray; Note=CnIE.;
CC       Evidence={ECO:0000269|PubMed:22705119};
CC   -!- MISCELLANEOUS: Found in injectable (milked) (IV) venom.
CC       {ECO:0000305|PubMed:22705119}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DKP7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..44
FT                   /evidence="ECO:0000305|PubMed:22705119"
FT                   /id="PRO_0000419871"
FT   PEPTIDE         45..59
FT                   /note="Alpha-conotoxin CnIJ"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419872"
FT   PEPTIDE         47..59
FT                   /note="Alpha-conotoxin CnIE"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT                   /id="PRO_0000419873"
FT   MOD_RES         59
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:22705119"
FT   DISULFID        47..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..59
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   61 AA;  6843 MW;  2A76EF20C68DAF5E CRC64;
     MMFTVFLLVV LTTTVVSFPS DSASDGRDDE AKDERSDMYE LKRNGRCCHP ACGGKYFKCG
     R