UNG_STRA3
ID UNG_STRA3 Reviewed; 217 AA.
AC P0A4P3; Q9XDS8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Uracil-DNA glycosylase;
DE Short=UDG;
DE EC=3.2.2.27;
GN Name=ung; OrderedLocusNames=gbs1231;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- FUNCTION: Excises uracil residues from the DNA which can arise as a
CC result of misincorporation of dUMP residues by DNA polymerase or due to
CC deamination of cytosine. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded
CC DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC UNG family. {ECO:0000305}.
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DR EMBL; AL766849; CAD46890.1; -; Genomic_DNA.
DR RefSeq; WP_000682955.1; NC_004368.1.
DR AlphaFoldDB; P0A4P3; -.
DR SMR; P0A4P3; -.
DR STRING; 211110.gbs1231; -.
DR PRIDE; P0A4P3; -.
DR EnsemblBacteria; CAD46890; CAD46890; CAD46890.
DR GeneID; 66886082; -.
DR KEGG; san:ung; -.
DR eggNOG; COG0692; Bacteria.
DR HOGENOM; CLU_032162_3_1_9; -.
DR OMA; PDNGYLM; -.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR CDD; cd10027; UDG-F1-like; 1.
DR Gene3D; 3.40.470.10; -; 1.
DR HAMAP; MF_00148; UDG; 1.
DR InterPro; IPR002043; UDG_fam1.
DR InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR11264; PTHR11264; 1.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SUPFAM; SSF52141; SSF52141; 1.
DR TIGRFAMs; TIGR00628; ung; 1.
DR PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Hydrolase.
FT CHAIN 1..217
FT /note="Uracil-DNA glycosylase"
FT /id="PRO_0000176145"
FT ACT_SITE 62
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24570 MW; EC6C29EF8732895B CRC64;
MKHSSWHDLI KRELPNHYYN KINTFMDAVY ESGIVYPPRD KVFNAIQITP LENVKVVIIG
QDPYHGPQQA QGLSFSVPDN LPAPPSLQNI LKELAEDIGS RSHHDLTSWA QQGVLLLNAC
LTVPEHQANG HAGLIWEPFT DAVIKVVNQK ETPVVFILWG GYARKKKSLI DNPIHHIIES
PHPSPLSAYR GFFGSRPFSR TNHFLEEEGI NEIDWLN