ID   UNG_SUHVF               Reviewed;         315 AA.
AC   P52506; Q69399;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-JUN-2021, entry version 76.
DE   RecName: Full=Uracil-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_04046};
DE            Short=UDG {ECO:0000255|HAMAP-Rule:MF_04046};
DE            EC=3.2.2.27 {ECO:0000255|HAMAP-Rule:MF_04046};
DE   AltName: Full=UNG {ECO:0000255|HAMAP-Rule:MF_04046};
GN   Name=UL2;
OS   Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1)
OS   (Pseudorabies virus (strain Indiana-Funkhauser / Becker)).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31523;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8189524; DOI=10.1128/jvi.68.6.3868-3878.1994;
RA   Klupp B.G., Baumeister J., Karger A., Visser N., Mettenleiter T.C.;
RT   "Identification and characterization of a novel structural glycoprotein in
RT   pseudorabies virus, gL.";
RL   J. Virol. 68:3868-3878(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8396663; DOI=10.1128/jvi.67.10.5955-5961.1993;
RA   Dean H.J., Cheung A.K.;
RT   "A 3' coterminal gene cluster in pseudorabies virus contains herpes simplex
RT   virus UL1, UL2, and UL3 gene homologs and a unique UL3.5 open reading
RT   frame.";
RL   J. Virol. 67:5955-5961(1993).
CC   -!- FUNCTION: Excises uracil residues from the DNA which can arise as a
CC       result of misincorporation of dUMP residues by DNA polymerase or
CC       deamination of cytosines. Therefore may reduce deleterious uracil
CC       incorporation into the viral genome, particularly in terminally
CC       differentiated cells which lack DNA repair enzymes. {ECO:0000255|HAMAP-
CC       Rule:MF_04046}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded
CC         DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_04046};
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04046}.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC       UNG family. {ECO:0000255|HAMAP-Rule:MF_04046}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16422.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U02512; AAA18856.1; -; Unassigned_DNA.
DR   EMBL; L13855; AAA16422.1; ALT_INIT; Unassigned_DNA.
DR   SMR; P52506; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd10027; UDG-F1-like; 1.
DR   Gene3D; 3.40.470.10; -; 1.
DR   HAMAP; MF_00148; UDG; 1.
DR   InterPro; IPR002043; UDG_fam1.
DR   InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR   InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR   InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR   PANTHER; PTHR11264; PTHR11264; 1.
DR   Pfam; PF03167; UDG; 1.
DR   SMART; SM00986; UDG; 1.
DR   SUPFAM; SSF52141; SSF52141; 1.
DR   TIGRFAMs; TIGR00628; ung; 1.
DR   PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Host nucleus; Hydrolase.
FT   CHAIN           1..315
FT                   /note="Uracil-DNA glycosylase"
FT                   /id="PRO_0000176195"
FT   REGION          35..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        158
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04046"
FT   CONFLICT        26
FT                   /note="A -> AA (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  32911 MW;  08363116D263DDC7 CRC64;
     MEGPPPSKRP CGLPPGVRLV VPAAAASASN AATAAAAAAP AGAGAGASKP ARPPAAARPA
     KGTPAASAAT TATGADASAP APDPGAPTWD AFAAEFDVAP SWRALLEPEI AKPYARLLLA
     EYRGRCLTEE VLPAREDVFA WTRLTAPEDV KVVIIGQDPY HGPGQAHGLA FSVRRGVPIP
     PSLANIFAAV RATYPTLPAP AHGCLEAWAR RGVLLLNTTL TVRRGVPGSH APLGWARLVR
     AVVQRLCETR PKLVFMLWGA HAQKACAPDP RRHKVLTFSH PSPLARTPFR TCPHFGEANA
     YLVQTGRAPV DWSVD