ID   CA1_CONQU               Reviewed;          68 AA.
AC   A1X8B8; A1X8C5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Putative alpha-conotoxin Qc alphaL-1;
DE            Short=QcaL-1;
DE   Flags: Precursor;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17400270; DOI=10.1016/j.toxicon.2007.02.011;
RA   Yuan D.-D., Han Y.-H., Wang C.-G., Chi C.-W.;
RT   "From the identification of gene organization of alpha conotoxins to the
RT   cloning of novel toxins.";
RL   Toxicon 49:1135-1149(2007).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is C-C-C. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The mature peptide contains 3 cysteine residues.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; DQ311058; ABD33850.1; -; Genomic_DNA.
DR   EMBL; DQ311065; ABD33857.1; -; mRNA.
DR   AlphaFoldDB; A1X8B8; -.
DR   TCDB; 8.B.32.1.2; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR   ConoServer; 548; Qc aL-1 precursor.
DR   ConoServer; 555; Qc aL-1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   5: Uncertain;
KW   Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000370665"
FT   PEPTIDE         50..68
FT                   /note="Putative alpha-conotoxin Qc alphaL-1"
FT                   /id="PRO_0000370666"
FT   DISULFID        51..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7580 MW;  14C64303FB62FCAA CRC64;
     MGMRMMFTMF LLVVLATTVV SINLDHAFDG RNAAANNKAT DLMARTVRRF CSDPPCRISN
     PESCGWEP