ID   UNPG_DROPS              Reviewed;         491 AA.
AC   Q28ZA9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Homeobox protein unplugged;
GN   Name=unpg {ECO:0000250|UniProtKB:Q4V5A3}; ORFNames=GA14073;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL25705.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Plays a regulatory role in neural branching of the tracheae:
CC       segment-specific aspects of these neural branching patterns appear to
CC       be generated by homeotic regulation of expression.
CC       {ECO:0000250|UniProtKB:Q4V5A3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q4V5A3,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL25705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000071; EAL25705.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001361128.1; XM_001361091.2.
DR   AlphaFoldDB; Q28ZA9; -.
DR   SMR; Q28ZA9; -.
DR   STRING; 7237.FBpp0276415; -.
DR   EnsemblMetazoa; FBtr0277977; FBpp0276415; FBgn0074104.
DR   GeneID; 4804593; -.
DR   KEGG; dpo:Dpse_GA14073; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_571441_0_0_1; -.
DR   InParanoid; Q28ZA9; -.
DR   OMA; MSPRNYN; -.
DR   PhylomeDB; Q28ZA9; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0074104; Expressed in adult organism.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0051960; P:regulation of nervous system development; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR042982; GBX-1/2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR031253; Unplugged.
DR   PANTHER; PTHR24334; PTHR24334; 1.
DR   PANTHER; PTHR24334:SF0; PTHR24334:SF0; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..491
FT                   /note="Homeobox protein unplugged"
FT                   /id="PRO_0000299500"
FT   DNA_BIND        323..382
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  52534 MW;  E384B9D8554EA95A CRC64;
     MERPALLQNG EHGAVGSLET KTTTRLMPKP FSIESLIATQ TPATVSASAS IAASPPSPPE
     DHEQEQEQEL SARAMVASSA LGLTQFPLYN PWLHGYFAQN HERLTHLIAG GGCYLGSPVG
     NPFAGKEPSH PHPPPPHALD KSPLPHPLDT RFLPFNASAA AAAASAATPT DLSYRRLAEL
     MNQDYVHNLS VNARLQHMAV AGRLQEDHPS HSLMHLQEPM LLQANPFSPA KSVSHSPVEP
     TLDVGVDEDY ECSGDSSSDI SLTLSPMPRN CNRELDKSRN GAYTNSDSED CSDDEGAHSH
     HDASGLGGKD SQGNGSGSSS SKSRRRRTAF TSEQLLELER EFHAKKYLSL TERSQIATSL
     KLSEVQVKIW FQNRRAKWKR VKAGLTSHGL GRNGSASGTK IVVPIPVHVN RFAVRSQHQQ
     LEKMCLSGPK PDLRKKLSTE AMSGFEKFNG GGLGGSAPSS STASVGAGSV GMGLALGIGV
     TTPLSLGRSI Y