CA210_HUMAN
ID CA210_HUMAN Reviewed; 113 AA.
AC Q8IVY1; D3DPX2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Type III endosome membrane protein TEMP {ECO:0000250|UniProtKB:Q9CQM1};
DE Short=TEMP {ECO:0000250|UniProtKB:Q9CQM1};
GN Name=C1orf210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in membrane trafficking between endosomes and
CC plasma membrane.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}. Early endosome
CC {ECO:0000250|UniProtKB:Q9CQM1}. Recycling endosome
CC {ECO:0000250|UniProtKB:Q9CQM1}. Cell membrane
CC {ECO:0000250|UniProtKB:Q9CQM1}. Note=Also localizes to tubular endosome
CC structures. {ECO:0000250|UniProtKB:Q9CQM1}.
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DR EMBL; CH471059; EAX07108.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07109.1; -; Genomic_DNA.
DR EMBL; BC041633; AAH41633.1; -; mRNA.
DR CCDS; CCDS481.1; -.
DR RefSeq; NP_001158301.1; NM_001164829.1.
DR RefSeq; NP_872323.1; NM_182517.2.
DR RefSeq; XP_011539104.1; XM_011540802.1.
DR AlphaFoldDB; Q8IVY1; -.
DR BioGRID; 127215; 31.
DR STRING; 9606.ENSP00000430918; -.
DR GlyGen; Q8IVY1; 3 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; Q8IVY1; -.
DR PhosphoSitePlus; Q8IVY1; -.
DR BioMuta; C1orf210; -.
DR DMDM; 74728100; -.
DR EPD; Q8IVY1; -.
DR jPOST; Q8IVY1; -.
DR MassIVE; Q8IVY1; -.
DR PaxDb; Q8IVY1; -.
DR PeptideAtlas; Q8IVY1; -.
DR PRIDE; Q8IVY1; -.
DR ProteomicsDB; 70791; -.
DR Antibodypedia; 52415; 47 antibodies from 12 providers.
DR DNASU; 149466; -.
DR Ensembl; ENST00000423420.1; ENSP00000429399.1; ENSG00000253313.6.
DR Ensembl; ENST00000523677.6; ENSP00000430918.1; ENSG00000253313.6.
DR GeneID; 149466; -.
DR KEGG; hsa:149466; -.
DR MANE-Select; ENST00000523677.6; ENSP00000430918.1; NM_182517.3; NP_872323.1.
DR UCSC; uc001cit.5; human.
DR CTD; 149466; -.
DR DisGeNET; 149466; -.
DR GeneCards; C1orf210; -.
DR HGNC; HGNC:28755; C1orf210.
DR HPA; ENSG00000253313; Tissue enhanced (intestine).
DR neXtProt; NX_Q8IVY1; -.
DR OpenTargets; ENSG00000253313; -.
DR PharmGKB; PA144596510; -.
DR VEuPathDB; HostDB:ENSG00000253313; -.
DR eggNOG; ENOG502S614; Eukaryota.
DR GeneTree; ENSGT00510000048988; -.
DR HOGENOM; CLU_2157591_0_0_1; -.
DR InParanoid; Q8IVY1; -.
DR OMA; AAKCHVC; -.
DR OrthoDB; 1580923at2759; -.
DR PhylomeDB; Q8IVY1; -.
DR TreeFam; TF338695; -.
DR PathwayCommons; Q8IVY1; -.
DR BioGRID-ORCS; 149466; 15 hits in 1057 CRISPR screens.
DR ChiTaRS; C1orf210; human.
DR GenomeRNAi; 149466; -.
DR Pharos; Q8IVY1; Tdark.
DR PRO; PR:Q8IVY1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8IVY1; protein.
DR Bgee; ENSG00000253313; Expressed in oocyte and 111 other tissues.
DR Genevisible; Q8IVY1; HS.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR033604; TEMP.
DR PANTHER; PTHR31450:SF3; PTHR31450:SF3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endosome; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..113
FT /note="Type III endosome membrane protein TEMP"
FT /id="PRO_0000271010"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q9CQM1"
FT TRANSMEM 30..50
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 12
FT /note="S -> L (in dbSNP:rs35465732)"
FT /id="VAR_033655"
SQ SEQUENCE 113 AA; 12024 MW; 55492589C5DDF35D CRC64;
MNETNKTLVG PSELPTASAV APGPGTGARA WPVLVGFVLG AVVLSLLIAL AAKCHLCRRY
HASYRHRPLP ETGRGGRPQV AEDEDDDGFI EDNYIQPGTG ELGTEGSRDH FSL
