CA210_MOUSE
ID CA210_MOUSE Reviewed; 111 AA.
AC Q9CQM1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Type III endosome membrane protein TEMP {ECO:0000303|PubMed:24710541};
DE Short=TEMP {ECO:0000303|PubMed:24710541};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Amnion, Embryo, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY, AND FUNCTION.
RX PubMed=24710541; DOI=10.3390/cells1041029;
RA Aturaliya R.N., Kerr M.C., Teasdale R.D.;
RT "A novel type III endosome transmembrane protein, TEMP.";
RL Cells 1:1029-1044(2012).
CC -!- FUNCTION: May be involved in membrane trafficking between endosomes and
CC plasma membrane. {ECO:0000303|PubMed:24710541}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}. Early endosome
CC {ECO:0000269|PubMed:24710541}. Recycling endosome
CC {ECO:0000269|PubMed:24710541}. Cell membrane
CC {ECO:0000303|PubMed:24710541}. Note=Also localizes to tubular endosome
CC structures. {ECO:0000269|PubMed:24710541}.
CC -!- TISSUE SPECIFICITY: Expressed in stomach, kidney, large and small
CC intestine and kidney. {ECO:0000269|PubMed:24710541}.
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DR EMBL; AK009128; BAB26091.1; -; mRNA.
DR EMBL; AK012175; BAB28079.1; -; mRNA.
DR EMBL; AK147115; BAE27687.1; -; mRNA.
DR EMBL; BC022764; AAH22764.1; -; mRNA.
DR CCDS; CCDS18554.1; -.
DR RefSeq; NP_079848.1; NM_025572.2.
DR RefSeq; XP_006503335.1; XM_006503272.2.
DR AlphaFoldDB; Q9CQM1; -.
DR SMR; Q9CQM1; -.
DR STRING; 10090.ENSMUSP00000030261; -.
DR GlyGen; Q9CQM1; 1 site.
DR PhosphoSitePlus; Q9CQM1; -.
DR PaxDb; Q9CQM1; -.
DR PRIDE; Q9CQM1; -.
DR Antibodypedia; 52415; 47 antibodies from 12 providers.
DR Ensembl; ENSMUST00000030261; ENSMUSP00000030261; ENSMUSG00000028536.
DR Ensembl; ENSMUST00000106367; ENSMUSP00000101975; ENSMUSG00000028536.
DR GeneID; 66451; -.
DR KEGG; mmu:66451; -.
DR UCSC; uc008ukj.1; mouse.
DR MGI; MGI:1913701; 2610528J11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000028536; -.
DR eggNOG; ENOG502S614; Eukaryota.
DR GeneTree; ENSGT00510000048988; -.
DR HOGENOM; CLU_2157591_0_0_1; -.
DR InParanoid; Q9CQM1; -.
DR OMA; GKGVCPE; -.
DR OrthoDB; 1580923at2759; -.
DR PhylomeDB; Q9CQM1; -.
DR TreeFam; TF338695; -.
DR BioGRID-ORCS; 66451; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q9CQM1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CQM1; protein.
DR Bgee; ENSMUSG00000028536; Expressed in yolk sac and 99 other tissues.
DR Genevisible; Q9CQM1; MM.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR033604; TEMP.
DR PANTHER; PTHR31450:SF3; PTHR31450:SF3; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Endosome; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..111
FT /note="Type III endosome membrane protein TEMP"
FT /id="PRO_0000271011"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000303|PubMed:24710541"
FT TRANSMEM 28..48
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..111
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 64..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 111 AA; 11532 MW; 77DFB4D461B59575 CRC64;
MIGGNTTIIS GAINASTEAP GLGTGGRAWP VLVGVVLGAV VLSILIALAA KCHLCRRYHA
SYRHRPLSSA GGGNRPPVGE DEDDDGFIED NYIQPGAGEM ETTGSRDHFS L
