CA216_HUMAN
ID CA216_HUMAN Reviewed; 229 AA.
AC Q8TAB5; D3DPS1; Q8N8N6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=UPF0500 protein C1orf216;
GN Name=C1orf216;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8TAB5; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-747505, EBI-11096309;
CC Q8TAB5; Q13155: AIMP2; NbExp=3; IntAct=EBI-747505, EBI-745226;
CC Q8TAB5; A2BDD9: AMOT; NbExp=3; IntAct=EBI-747505, EBI-17286414;
CC Q8TAB5; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-747505, EBI-3891843;
CC Q8TAB5; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-747505, EBI-10193358;
CC Q8TAB5; P27797: CALR; NbExp=3; IntAct=EBI-747505, EBI-1049597;
CC Q8TAB5; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-747505, EBI-10171416;
CC Q8TAB5; Q8NCU1: CCDC197; NbExp=8; IntAct=EBI-747505, EBI-750686;
CC Q8TAB5; Q01850: CDR2; NbExp=6; IntAct=EBI-747505, EBI-1181367;
CC Q8TAB5; Q86X02: CDR2L; NbExp=3; IntAct=EBI-747505, EBI-11063830;
CC Q8TAB5; Q9H3R5: CENPH; NbExp=3; IntAct=EBI-747505, EBI-1003700;
CC Q8TAB5; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-747505, EBI-747776;
CC Q8TAB5; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-747505, EBI-1045797;
CC Q8TAB5; Q9NRP2: CMC2; NbExp=3; IntAct=EBI-747505, EBI-16780661;
CC Q8TAB5; P17661: DES; NbExp=3; IntAct=EBI-747505, EBI-1055572;
CC Q8TAB5; P36957: DLST; NbExp=3; IntAct=EBI-747505, EBI-351007;
CC Q8TAB5; Q9NPF5: DMAP1; NbExp=5; IntAct=EBI-747505, EBI-399105;
CC Q8TAB5; O00303: EIF3F; NbExp=3; IntAct=EBI-747505, EBI-711990;
CC Q8TAB5; O00471: EXOC5; NbExp=3; IntAct=EBI-747505, EBI-949824;
CC Q8TAB5; A1L4K1: FSD2; NbExp=3; IntAct=EBI-747505, EBI-5661036;
CC Q8TAB5; Q9UJY5: GGA1; NbExp=3; IntAct=EBI-747505, EBI-447141;
CC Q8TAB5; Q9UJY5-4: GGA1; NbExp=3; IntAct=EBI-747505, EBI-12108696;
CC Q8TAB5; P17302: GJA1; NbExp=3; IntAct=EBI-747505, EBI-1103439;
CC Q8TAB5; P28799: GRN; NbExp=3; IntAct=EBI-747505, EBI-747754;
CC Q8TAB5; P54257: HAP1; NbExp=3; IntAct=EBI-747505, EBI-712814;
CC Q8TAB5; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-747505, EBI-2558143;
CC Q8TAB5; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-747505, EBI-9091197;
CC Q8TAB5; O60333-2: KIF1B; NbExp=3; IntAct=EBI-747505, EBI-10975473;
CC Q8TAB5; Q9BS75: KLHL20; NbExp=3; IntAct=EBI-747505, EBI-10693436;
CC Q8TAB5; A1A4E9: KRT13; NbExp=3; IntAct=EBI-747505, EBI-10171552;
CC Q8TAB5; P19012: KRT15; NbExp=4; IntAct=EBI-747505, EBI-739566;
CC Q8TAB5; P08779: KRT16; NbExp=3; IntAct=EBI-747505, EBI-356410;
CC Q8TAB5; Q2M2I5: KRT24; NbExp=5; IntAct=EBI-747505, EBI-2952736;
CC Q8TAB5; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-747505, EBI-3044087;
CC Q8TAB5; Q15323: KRT31; NbExp=6; IntAct=EBI-747505, EBI-948001;
CC Q8TAB5; Q14525: KRT33B; NbExp=3; IntAct=EBI-747505, EBI-1049638;
CC Q8TAB5; O76011: KRT34; NbExp=3; IntAct=EBI-747505, EBI-1047093;
CC Q8TAB5; O76013-2: KRT36; NbExp=3; IntAct=EBI-747505, EBI-11958506;
CC Q8TAB5; O76015: KRT38; NbExp=6; IntAct=EBI-747505, EBI-1047263;
CC Q8TAB5; Q6A163: KRT39; NbExp=3; IntAct=EBI-747505, EBI-11958242;
CC Q8TAB5; Q6A162: KRT40; NbExp=3; IntAct=EBI-747505, EBI-10171697;
CC Q8TAB5; O95678: KRT75; NbExp=3; IntAct=EBI-747505, EBI-2949715;
CC Q8TAB5; Q01546: KRT76; NbExp=3; IntAct=EBI-747505, EBI-2952745;
CC Q8TAB5; Q9BV99: LRRC61; NbExp=3; IntAct=EBI-747505, EBI-2350424;
CC Q8TAB5; P43360: MAGEA6; NbExp=3; IntAct=EBI-747505, EBI-1045155;
CC Q8TAB5; Q99750: MDFI; NbExp=3; IntAct=EBI-747505, EBI-724076;
CC Q8TAB5; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-747505, EBI-394607;
CC Q8TAB5; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-747505, EBI-1104552;
CC Q8TAB5; Q9BV36: MLPH; NbExp=3; IntAct=EBI-747505, EBI-7042162;
CC Q8TAB5; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-747505, EBI-748896;
CC Q8TAB5; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-747505, EBI-742948;
CC Q8TAB5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-747505, EBI-11522433;
CC Q8TAB5; Q8NFW9: MYRIP; NbExp=6; IntAct=EBI-747505, EBI-1759414;
CC Q8TAB5; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-747505, EBI-10172876;
CC Q8TAB5; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-747505, EBI-1055945;
CC Q8TAB5; Q13287: NMI; NbExp=6; IntAct=EBI-747505, EBI-372942;
CC Q8TAB5; Q96F24: NRBF2; NbExp=3; IntAct=EBI-747505, EBI-2362014;
CC Q8TAB5; P37198: NUP62; NbExp=6; IntAct=EBI-747505, EBI-347978;
CC Q8TAB5; Q96M63: ODAD1; NbExp=6; IntAct=EBI-747505, EBI-10173858;
CC Q8TAB5; P16284: PECAM1; NbExp=3; IntAct=EBI-747505, EBI-716404;
CC Q8TAB5; Q96KN3: PKNOX2; NbExp=5; IntAct=EBI-747505, EBI-2692890;
CC Q8TAB5; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-747505, EBI-710402;
CC Q8TAB5; P62333: PSMC6; NbExp=4; IntAct=EBI-747505, EBI-357669;
CC Q8TAB5; P20339: RAB5A; NbExp=3; IntAct=EBI-747505, EBI-399437;
CC Q8TAB5; Q15311: RALBP1; NbExp=6; IntAct=EBI-747505, EBI-749285;
CC Q8TAB5; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-747505, EBI-748621;
CC Q8TAB5; Q13573: SNW1; NbExp=3; IntAct=EBI-747505, EBI-632715;
CC Q8TAB5; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-747505, EBI-5235340;
CC Q8TAB5; P37173: TGFBR2; NbExp=3; IntAct=EBI-747505, EBI-296151;
CC Q8TAB5; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-747505, EBI-741515;
CC Q8TAB5; Q08117: TLE5; NbExp=3; IntAct=EBI-747505, EBI-717810;
CC Q8TAB5; Q8N6Q1: TMCO5A; NbExp=3; IntAct=EBI-747505, EBI-12821895;
CC Q8TAB5; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-747505, EBI-11952721;
CC Q8TAB5; P09493: TPM1; NbExp=3; IntAct=EBI-747505, EBI-351158;
CC Q8TAB5; P06753: TPM3; NbExp=4; IntAct=EBI-747505, EBI-355607;
CC Q8TAB5; Q5VU62: TPM3; NbExp=3; IntAct=EBI-747505, EBI-10184033;
CC Q8TAB5; Q13077: TRAF1; NbExp=6; IntAct=EBI-747505, EBI-359224;
CC Q8TAB5; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-747505, EBI-2130429;
CC Q8TAB5; Q6ZMU5: TRIM72; NbExp=3; IntAct=EBI-747505, EBI-2341648;
CC Q8TAB5; Q8N6Y0: USHBP1; NbExp=7; IntAct=EBI-747505, EBI-739895;
CC Q8TAB5; P08670: VIM; NbExp=3; IntAct=EBI-747505, EBI-353844;
CC Q8TAB5; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-747505, EBI-2799833;
CC Q8TAB5; O76024: WFS1; NbExp=3; IntAct=EBI-747505, EBI-720609;
CC Q8TAB5; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-747505, EBI-4395669;
CC -!- SIMILARITY: Belongs to the UPF0500 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04799.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK096303; BAC04755.1; -; mRNA.
DR EMBL; AK096466; BAC04799.1; ALT_INIT; mRNA.
DR EMBL; CH471059; EAX07403.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07404.1; -; Genomic_DNA.
DR EMBL; BC026909; AAH26909.1; -; mRNA.
DR CCDS; CCDS395.1; -.
DR RefSeq; NP_001335620.1; NM_001348691.1.
DR RefSeq; NP_689587.1; NM_152374.1.
DR AlphaFoldDB; Q8TAB5; -.
DR SMR; Q8TAB5; -.
DR BioGRID; 126079; 72.
DR IntAct; Q8TAB5; 89.
DR MINT; Q8TAB5; -.
DR STRING; 9606.ENSP00000425166; -.
DR iPTMnet; Q8TAB5; -.
DR PhosphoSitePlus; Q8TAB5; -.
DR BioMuta; C1orf216; -.
DR DMDM; 74730336; -.
DR jPOST; Q8TAB5; -.
DR MassIVE; Q8TAB5; -.
DR PaxDb; Q8TAB5; -.
DR PeptideAtlas; Q8TAB5; -.
DR PRIDE; Q8TAB5; -.
DR ProteomicsDB; 73852; -.
DR Antibodypedia; 31583; 85 antibodies from 17 providers.
DR DNASU; 127703; -.
DR Ensembl; ENST00000270815.5; ENSP00000425166.1; ENSG00000142686.8.
DR GeneID; 127703; -.
DR KEGG; hsa:127703; -.
DR MANE-Select; ENST00000270815.5; ENSP00000425166.1; NM_152374.2; NP_689587.1.
DR UCSC; uc001bzh.2; human.
DR CTD; 127703; -.
DR GeneCards; C1orf216; -.
DR HGNC; HGNC:26800; C1orf216.
DR HPA; ENSG00000142686; Tissue enhanced (brain).
DR neXtProt; NX_Q8TAB5; -.
DR OpenTargets; ENSG00000142686; -.
DR PharmGKB; PA162378892; -.
DR VEuPathDB; HostDB:ENSG00000142686; -.
DR eggNOG; ENOG502S1PX; Eukaryota.
DR GeneTree; ENSGT00390000001867; -.
DR HOGENOM; CLU_1156086_0_0_1; -.
DR InParanoid; Q8TAB5; -.
DR OMA; GMPGKVE; -.
DR OrthoDB; 1593675at2759; -.
DR PhylomeDB; Q8TAB5; -.
DR TreeFam; TF335932; -.
DR PathwayCommons; Q8TAB5; -.
DR SignaLink; Q8TAB5; -.
DR BioGRID-ORCS; 127703; 42 hits in 1057 CRISPR screens.
DR ChiTaRS; C1orf216; human.
DR GenomeRNAi; 127703; -.
DR Pharos; Q8TAB5; Tdark.
DR PRO; PR:Q8TAB5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TAB5; protein.
DR Bgee; ENSG00000142686; Expressed in middle temporal gyrus and 165 other tissues.
DR Genevisible; Q8TAB5; HS.
DR InterPro; IPR027812; DUF4653.
DR PANTHER; PTHR35673; PTHR35673; 1.
DR Pfam; PF15546; DUF4653; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..229
FT /note="UPF0500 protein C1orf216"
FT /id="PRO_0000309178"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 19
FT /note="P -> T (in Ref. 1; BAC04799)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 24968 MW; 281250E30DC4E730 CRC64;
MFAIQPGLAE GGQFLGDPPP GLCQPELQPD SNSNFMASAK DANENWHGMP GRVEPILRRS
SSESPSDNQA FQAPGSPEEG VRSPPEGAEI PGAEPEKMGG AGTVCSPLED NGYASSSLSI
DSRSSSPEPA CGTPRGPGPP DPLLPSVAQA VQHLQVQERY KEQEKEKHHV HLVMYRRLAL
LQWIRGLQHQ LIDQQARLQE SFDTILDNRK ELIRCLQQRA APSRPQDQA
