ID   UP1_RAT                 Reviewed;         101 AA.
AC   P81827; Q53ZD7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Urinary protein 1;
DE            Short=UP-1;
DE            Short=rUP-1;
DE   AltName: Full=Liver regeneration-related protein LRRG05;
DE   Flags: Precursor;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-47, AND IDENTIFICATION.
RC   TISSUE=Urine;
RX   PubMed=11840564;
RX   DOI=10.1002/1615-9861(200202)2:2<187::aid-prot187>3.0.co;2-a;
RA   Southan C., Cutler P., Birrell H., Connell J., Fantom K.G.M., Sims M.,
RA   Shaikh N., Schneider K.;
RT   "The characterisation of novel secreted Ly-6 proteins from rat urine by the
RT   combined use of two-dimensional gel electrophoresis, microbore high
RT   performance liquid chromatography and expressed sequence tag data.";
RL   Proteomics 2:187-196(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RA   Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yang K.J.,
RA   Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Shi J.B.,
RA   Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 22-37 AND 42-62.
RX   PubMed=11565799;
RX   DOI=10.1002/1522-2683(200108)22:14<3043::aid-elps3043>3.0.co;2-m;
RA   Wait R., Gianazza E., Eberini I., Sironi L., Dunn M.J., Gemeiner M.,
RA   Miller I.;
RT   "Proteins of rat serum, urine, and cerebrospinal fluid: VI. Further protein
RT   identifications and interstrain comparison.";
RL   Electrophoresis 22:3043-3052(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: N-glycosylated. {ECO:0000305}.
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DR   EMBL; AF198441; AAF15598.1; -; mRNA.
DR   EMBL; AY327506; AAP97738.1; -; mRNA.
DR   RefSeq; NP_001030122.2; NM_001034950.2.
DR   AlphaFoldDB; P81827; -.
DR   SMR; P81827; -.
DR   STRING; 10116.ENSRNOP00000050106; -.
DR   GlyGen; P81827; 1 site.
DR   PaxDb; P81827; -.
DR   Ensembl; ENSRNOT00000042860; ENSRNOP00000050106; ENSRNOG00000045799.
DR   GeneID; 619560; -.
DR   KEGG; rno:619560; -.
DR   UCSC; RGD:1561250; rat.
DR   CTD; 619560; -.
DR   GeneTree; ENSGT00940000163158; -.
DR   HOGENOM; CLU_178161_0_0_1; -.
DR   InParanoid; P81827; -.
DR   OrthoDB; 1575740at2759; -.
DR   PhylomeDB; P81827; -.
DR   TreeFam; TF337781; -.
DR   PRO; PR:P81827; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000045799; Expressed in liver and 17 other tissues.
DR   Genevisible; P81827; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:11565799,
FT                   ECO:0000269|PubMed:11840564"
FT   CHAIN           22..101
FT                   /note="Urinary protein 1"
FT                   /id="PRO_0000036169"
FT   DOMAIN          22..99
FT                   /note="UPAR/Ly6"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        24..51
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..36
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..70
FT                   /evidence="ECO:0000255"
FT   DISULFID        73..89
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..96
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  10960 MW;  03021BC9FFE75646 CRC64;
     MGKPILLLPL GLSLLMSSLL ALQCFRCESL DSTGLCRVGR RICQTYPDEI CAWVVVTTRD
     GKFVYGNQSC AECIGTTVEH GSLIISTNCC SATPFCNMVH P