ID   UP1_URTPI               Reviewed;          46 AA.
AC   P0C1G1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Toxin Up-1;
DE            Short=UpI {ECO:0000303|PubMed:8868062};
DE   Flags: Fragment;
OS   Urticina piscivora (Fish-eating sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Urticina.
OX   NCBI_TaxID=386596;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RX   PubMed=8868062; DOI=10.1016/s1043-6618(05)80020-9;
RA   Cline E.I., Wiebe L.I., Young J.D., Samuel J.;
RT   "Toxic effects of the novel protein UpI from the sea anemone Urticina
RT   piscivora.";
RL   Pharmacol. Res. 32:309-314(1995).
RN   [2]
RP   FUNCTION, AND BIOASSAY.
RA   Cline E.I.;
RT   "UpI: in vivo studies involving the potent cardiac stimulant and haemolysin
RT   from the sea anemone Urticina piscivora.";
RL   Phytother. Res. 11:348-353(1997).
CC   -!- FUNCTION: This toxin is a potent hemolysin devoid of enzymatic
CC       activity. Its hemolytic activity is inhibited by sphingomyelin but not
CC       by cholesterol. In erythrocyte membranes, it causes numerous cell
CC       membrane ruptures. It also exerces cytotoxicity to different cell
CC       lines. It exerces a positive inotropic effect. Also causes hemorrhage
CC       and necrosis by dilation of the blood vessels in the skin, and vascular
CC       leakage of fluids and rupture of alveolar walls of the lungs. Is a
CC       potent ichtyotoxin. May act as a pore-forming toxin.
CC       {ECO:0000269|PubMed:8868062, ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst. Target cell membrane
CC       {ECO:0000250}. Note=Forms a membrane channel in the prey.
CC       {ECO:0000250}.
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DR   AlphaFoldDB; P0C1G1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Hemolysis; Ion transport; Membrane;
KW   Nematocyst; Secreted; Target cell membrane; Target membrane; Toxin;
KW   Transmembrane; Transport.
FT   CHAIN           1..>46
FT                   /note="Toxin Up-1"
FT                   /id="PRO_0000239810"
FT   NON_TER         46
SQ   SEQUENCE   46 AA;  4989 MW;  5B6C519B2DF6B9CB CRC64;
     DENENLYGPN ENKAKAKDLT AGASYLTKEA GCTKLQAGCT MYQAYN