UP2_RAT
ID UP2_RAT Reviewed; 101 AA.
AC P81828;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Urinary protein 2;
DE Short=UP-2;
DE Short=rUP-2;
DE Flags: Precursor;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J.,
RA Kerlavage A.R., Adams M.D.;
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION, AND PROTEIN SEQUENCE OF 22-47.
RC TISSUE=Urine;
RX PubMed=11840564;
RX DOI=10.1002/1615-9861(200202)2:2<187::aid-prot187>3.0.co;2-a;
RA Southan C., Cutler P., Birrell H., Connell J., Fantom K.G.M., Sims M.,
RA Shaikh N., Schneider K.;
RT "The characterisation of novel secreted Ly-6 proteins from rat urine by the
RT combined use of two-dimensional gel electrophoresis, microbore high
RT performance liquid chromatography and expressed sequence tag data.";
RL Proteomics 2:187-196(2002).
RN [3]
RP PROTEIN SEQUENCE OF 27-40.
RX PubMed=11565799;
RX DOI=10.1002/1522-2683(200108)22:14<3043::aid-elps3043>3.0.co;2-m;
RA Wait R., Gianazza E., Eberini I., Sironi L., Dunn M.J., Gemeiner M.,
RA Miller I.;
RT "Proteins of rat serum, urine, and cerebrospinal fluid: VI. Further protein
RT identifications and interstrain comparison.";
RL Electrophoresis 22:3043-3052(2001).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: N-glycosylated. {ECO:0000305}.
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DR EMBL; AA945091; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P81828; -.
DR SMR; P81828; -.
DR GlyGen; P81828; 2 sites.
DR PaxDb; P81828; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:11840564"
FT CHAIN 22..101
FT /note="Urinary protein 2"
FT /id="PRO_0000036170"
FT DOMAIN 22..99
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..51
FT /evidence="ECO:0000255"
FT DISULFID 27..36
FT /evidence="ECO:0000255"
FT DISULFID 43..70
FT /evidence="ECO:0000255"
FT DISULFID 73..89
FT /evidence="ECO:0000255"
FT DISULFID 90..96
FT /evidence="ECO:0000255"
SQ SEQUENCE 101 AA; 11068 MW; 538BD57FA3033857 CRC64;
MGKHILLLPL GLSLLMSSLL ALQCFRCTSF DSTGFCHVGR QKCQTYPDEI CAWVVVTTRD
GKFVYGNQSC AECNATTVEH GSLIVSTNCC SATPFCNMVH R