UP3_ARATH
ID UP3_ARATH Reviewed; 263 AA.
AC Q9SIP1; Q0WR03;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Stress-response A/B barrel domain-containing protein UP3 {ECO:0000305};
DE AltName: Full=Unknown protein 3 {ECO:0000303|PubMed:17951448};
GN Name=UP3 {ECO:0000303|PubMed:17951448};
GN OrderedLocusNames=At2g31670 {ECO:0000312|Araport:AT2G31670};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17951448; DOI=10.1105/tpc.107.050989;
RA Reumann S., Babujee L., Ma C., Wienkoop S., Siemsen T., Antonicelli G.E.,
RA Rasche N., Lueder F., Weckwerth W., Jahn O.;
RT "Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting
RT peptides, metabolic pathways, and defense mechanisms.";
RL Plant Cell 19:3170-3193(2007).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=24130194; DOI=10.1104/pp.113.223453;
RA Quan S., Yang P., Cassin-Ross G., Kaur N., Switzenberg R., Aung K., Li J.,
RA Hu J.;
RT "Proteome analysis of peroxisomes from etiolated Arabidopsis seedlings
RT identifies a peroxisomal protease involved in beta-oxidation and
RT development.";
RL Plant Physiol. 163:1518-1538(2013).
CC -!- FUNCTION: Involved in stress response. {ECO:0000305}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9LUV2}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:24130194}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF00446.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007071; AAD24844.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08571.1; -; Genomic_DNA.
DR EMBL; BT010905; AAR24683.1; -; mRNA.
DR EMBL; BT011004; AAR25640.1; -; mRNA.
DR EMBL; AK228524; BAF00446.1; ALT_INIT; mRNA.
DR PIR; F84723; F84723.
DR RefSeq; NP_180725.1; NM_128724.4.
DR AlphaFoldDB; Q9SIP1; -.
DR SMR; Q9SIP1; -.
DR STRING; 3702.AT2G31670.1; -.
DR iPTMnet; Q9SIP1; -.
DR MetOSite; Q9SIP1; -.
DR PaxDb; Q9SIP1; -.
DR PRIDE; Q9SIP1; -.
DR ProteomicsDB; 232999; -.
DR EnsemblPlants; AT2G31670.1; AT2G31670.1; AT2G31670.
DR GeneID; 817723; -.
DR Gramene; AT2G31670.1; AT2G31670.1; AT2G31670.
DR KEGG; ath:AT2G31670; -.
DR Araport; AT2G31670; -.
DR TAIR; locus:2065949; AT2G31670.
DR eggNOG; ENOG502QTKV; Eukaryota.
DR HOGENOM; CLU_087754_0_0_1; -.
DR InParanoid; Q9SIP1; -.
DR OMA; SAMRVTF; -.
DR OrthoDB; 1217016at2759; -.
DR PhylomeDB; Q9SIP1; -.
DR PRO; PR:Q9SIP1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIP1; baseline and differential.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; HDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005777; C:peroxisome; IDA:TAIR.
DR InterPro; IPR013097; Dabb.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR044662; HS1/DABB1-like.
DR PANTHER; PTHR33178; PTHR33178; 1.
DR Pfam; PF07876; Dabb; 2.
DR SMART; SM00886; Dabb; 2.
DR SUPFAM; SSF54909; SSF54909; 2.
DR PROSITE; PS51502; S_R_A_B_BARREL; 2.
PE 1: Evidence at protein level;
KW Peroxisome; Reference proteome; Stress response.
FT CHAIN 1..263
FT /note="Stress-response A/B barrel domain-containing protein
FT UP3"
FT /id="PRO_0000436070"
FT DOMAIN 49..142
FT /note="Stress-response A/B barrel 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00835"
FT DOMAIN 158..252
FT /note="Stress-response A/B barrel 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00835"
FT MOTIF 261..263
FT /note="Peroxisomal targeting signal"
FT /evidence="ECO:0000305|PubMed:24130194"
SQ SEQUENCE 263 AA; 28865 MW; 9C7718A4E2E27BE4 CRC64;
MICARIRPLI SSPLAFTIST TKHSRINLRL LPRRSFSVMS SSTPQSQIIE HIVLFKTKDD
ADSTKITSMI NNLNALAYLD QVLHISTSPL HRISSATAFT HVLHSRYESK EDLASYAAHP
DHVRVVKESV LPICDDIMAV DWIADRIPGT VAPLPGSVAK LTLLKLKEDV ADEAKSEITG
VIKGLSEKFP GIDQITVGEN FSPARAKGFS IASIAYFKDL SEMEAVDAQK ELVNSQKDKV
RDYVDSTIVV EFVVPSSSQS SSL
