UPK1B_MOUSE
ID UPK1B_MOUSE Reviewed; 260 AA.
AC Q9Z2C6; Q8C448; Q8K4M0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uroplakin-1b;
DE Short=UP1b;
DE AltName: Full=Uroplakin Ib;
DE Short=UPIb;
GN Name=Upk1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Urinary bladder;
RA Zhou G., Kong X.-P.;
RT "Mouse uroplakin Ib (UPIb) mRNA.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Hippocampus, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-141.
RX PubMed=10343097; DOI=10.1159/000015208;
RA Webb G.C., Finch J.L., Cowled P.A.;
RT "Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands
RT B5-C2 by in situ hybridization.";
RL Cytogenet. Cell Genet. 84:37-38(1999).
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in normal bladder
CC epithelial physiology, possibly in regulating membrane permeability of
CC superficial umbrella cells or in stabilizing the apical membrane
CC through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Bladder epithelium.
CC -!- PTM: N-glycosylated with high-mannose oligosaccharides. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF274865; AAM97593.1; -; mRNA.
DR EMBL; AK053004; BAC35237.1; -; mRNA.
DR EMBL; AK083101; BAC38760.1; -; mRNA.
DR EMBL; AK086926; BAC39763.1; -; mRNA.
DR EMBL; BC046604; AAH46604.1; -; mRNA.
DR EMBL; AF073956; AAD02834.1; -; Genomic_DNA.
DR CCDS; CCDS28174.1; -.
DR RefSeq; NP_849255.2; NM_178924.4.
DR RefSeq; XP_017172432.1; XM_017316943.1.
DR AlphaFoldDB; Q9Z2C6; -.
DR IntAct; Q9Z2C6; 2.
DR STRING; 10090.ENSMUSP00000052469; -.
DR PhosphoSitePlus; Q9Z2C6; -.
DR MaxQB; Q9Z2C6; -.
DR PaxDb; Q9Z2C6; -.
DR PRIDE; Q9Z2C6; -.
DR ProteomicsDB; 297869; -.
DR Antibodypedia; 32685; 240 antibodies from 28 providers.
DR Ensembl; ENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436.
DR GeneID; 22268; -.
DR KEGG; mmu:22268; -.
DR UCSC; uc007zfm.2; mouse.
DR CTD; 7348; -.
DR MGI; MGI:98912; Upk1b.
DR VEuPathDB; HostDB:ENSMUSG00000049436; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000160779; -.
DR HOGENOM; CLU_088971_1_0_1; -.
DR InParanoid; Q9Z2C6; -.
DR OMA; QDHCCGV; -.
DR OrthoDB; 944403at2759; -.
DR PhylomeDB; Q9Z2C6; -.
DR TreeFam; TF335659; -.
DR BioGRID-ORCS; 22268; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9Z2C6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9Z2C6; protein.
DR Bgee; ENSMUSG00000049436; Expressed in urinary bladder urothelium and 118 other tissues.
DR Genevisible; Q9Z2C6; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0120001; C:apical plasma membrane urothelial plaque; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; ISO:MGI.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR InterPro; IPR034766; Uroplakin-1b.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR PANTHER; PTHR19282:SF24; PTHR19282:SF24; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..260
FT /note="Uroplakin-1b"
FT /id="PRO_0000219290"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 136
FT /note="T -> N (in Ref. 4; AAD02834)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="E -> Q (in Ref. 4; AAD02834)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="F -> L (in Ref. 2; BAC38760)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29762 MW; 91EB5816D59070A4 CRC64;
MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT NNDDIFGAAW
IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG FEVASCITAA TQRDFFTTNL
FLKQMLMRYQ NNSPPTNDDE WKNNGVTKTW DRLMLQDHCC GVNGPSDWQK YTSAFRVENN
DADYPWPRQC CVMDKLKEPL NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI
LCWTFWVLLG TMFYWSRIEY
