ID   UPK1B_NEOVI             Reviewed;         260 AA.
AC   P30413;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uroplakin-1b;
DE            Short=UP1b;
DE   AltName: Full=Protein TI 1;
DE   AltName: Full=Uroplakin Ib;
DE            Short=UPIb;
GN   Name=UPK1B;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung epithelium;
RX   PubMed=1922049; DOI=10.1128/mcb.11.10.5338-5345.1991;
RA   Kallin B., de Martin R., Etzold T., Sorrentino V., Philipson L.;
RT   "Cloning of a growth arrest-specific and transforming growth factor beta-
RT   regulated gene, TI 1, from an epithelial cell line.";
RL   Mol. Cell. Biol. 11:5338-5345(1991).
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC       specialized biomembrane elaborated by terminally differentiated
CC       urothelial cells.
CC   -!- SUBUNIT: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: Down-regulated by TGF-beta and serum in quiescent cells.
CC       Rapidly and transiently induced by TGF-beta in actively growing cells.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; M64428; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A41531; A41531.
DR   AlphaFoldDB; P30413; -.
DR   SMR; P30413; -.
DR   Ensembl; ENSNVIT00000016835; ENSNVIP00000014418; ENSNVIG00000011317.
DR   GeneTree; ENSGT00940000160779; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0120001; C:apical plasma membrane urothelial plaque; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   InterPro; IPR034766; Uroplakin-1b.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   PANTHER; PTHR19282:SF24; PTHR19282:SF24; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="Uroplakin-1b"
FT                   /id="PRO_0000219291"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..60
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..229
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29686 MW;  5F83FD17B1DBE9B7 CRC64;
     MAKDDSSVRC FQGLLIFGNV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW
     IGMFVGICLF CLSVLGIVGI MKSNRKILLA YFILMFIVYG FEVASCITAA TQRDFFTPNL
     FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDHCC GVNGPSDWQR YTSAFRTANN
     DADYPWPRQC CVMNSLKEPL NVEACKLGVP GYYHKEGCYE LISGPMNRHA WGVAWFGFAI
     LCWTFWVLLG TMFYWSRIEY