ID   UPK1B_RAT               Reviewed;         260 AA.
AC   Q566D0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Uroplakin-1b;
DE            Short=UP1b;
DE   AltName: Full=Uroplakin Ib;
DE            Short=UPIb;
GN   Name=Upk1b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC       specialized biomembrane elaborated by terminally differentiated
CC       urothelial cells. May play an important role in normal bladder
CC       epithelial physiology, possibly in regulating membrane permeability of
CC       superficial umbrella cells or in stabilizing the apical membrane
CC       through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- PTM: N-glycosylated with high-mannose oligosaccharides. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC093613; AAH93613.1; -; mRNA.
DR   RefSeq; NP_001019424.1; NM_001024253.1.
DR   RefSeq; XP_006248430.1; XM_006248368.3.
DR   AlphaFoldDB; Q566D0; -.
DR   SMR; Q566D0; -.
DR   STRING; 10116.ENSRNOP00000004315; -.
DR   PaxDb; Q566D0; -.
DR   PRIDE; Q566D0; -.
DR   GeneID; 303924; -.
DR   KEGG; rno:303924; -.
DR   CTD; 7348; -.
DR   RGD; 1307806; Upk1b.
DR   eggNOG; KOG3882; Eukaryota.
DR   HOGENOM; CLU_088971_1_0_1; -.
DR   InParanoid; Q566D0; -.
DR   PhylomeDB; Q566D0; -.
DR   TreeFam; TF335659; -.
DR   PRO; PR:Q566D0; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q566D0; RN.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR   GO; GO:0120001; C:apical plasma membrane urothelial plaque; ISO:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; ISO:RGD.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   InterPro; IPR034766; Uroplakin-1b.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   PANTHER; PTHR19282:SF24; PTHR19282:SF24; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="Uroplakin-1b"
FT                   /id="PRO_0000219292"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..229
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29813 MW;  97FAB4CE28937EBE CRC64;
     MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT NNDDIFGAAW
     IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG FEVASCITAA TQRDFFTTNL
     FLKQMLMRYQ NNSPPTNDDK WKNSYVTKTW DRLMLQDHCC GVNGPSDWQK YTSAFRVENS
     DADYPWPRQC CVMDKLQEPL NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI
     LCWTFWVLLG TMFYWSRIEY