UPK2_BOVIN
ID UPK2_BOVIN Reviewed; 185 AA.
AC Q08537;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uroplakin-2;
DE Short=UP2;
DE AltName: Full=Uroplakin II;
DE Short=UPII;
DE Flags: Precursor;
GN Name=UPK2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Urinary bladder urothelium;
RX PubMed=7507484; DOI=10.1016/s0021-9258(17)42095-3;
RA Lin J.-H., Wu X.-R., Kreibich G., Sun T.-T.;
RT "Precursor sequence, processing, and urothelium-specific expression of a
RT major 15-kDa protein subunit of asymmetric unit membrane.";
RL J. Biol. Chem. 269:1775-1784(1994).
RN [2]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH UPK1A.
RX PubMed=12475947; DOI=10.1091/mbc.e02-04-0211;
RA Tu L., Sun T.-T., Kreibich G.;
RT "Specific heterodimer formation is a prerequisite for uroplakins to exit
RT from the endoplasmic reticulum.";
RL Mol. Biol. Cell 13:4221-4230(2002).
CC -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC specialized biomembrane elaborated by terminally differentiated
CC urothelial cells. May play an important role in regulating the assembly
CC of the AUM.
CC -!- SUBUNIT: Interacts with uroplakin-1a (UPK1A).
CC {ECO:0000269|PubMed:12475947}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A
CC is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC {ECO:0000269|PubMed:12475947}.
CC -!- TISSUE SPECIFICITY: Bladder epithelium.
CC -!- SIMILARITY: Belongs to the uroplakin-2 family. {ECO:0000305}.
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DR EMBL; L20633; AAC37317.1; -; mRNA.
DR PIR; A49713; A49713.
DR RefSeq; NP_776639.1; NM_174214.2.
DR RefSeq; XP_010810719.1; XM_010812417.2.
DR AlphaFoldDB; Q08537; -.
DR STRING; 9913.ENSBTAP00000016947; -.
DR PaxDb; Q08537; -.
DR Ensembl; ENSBTAT00000016947; ENSBTAP00000016947; ENSBTAG00000012750.
DR GeneID; 281569; -.
DR KEGG; bta:281569; -.
DR CTD; 7379; -.
DR VEuPathDB; HostDB:ENSBTAG00000012750; -.
DR VGNC; VGNC:36686; UPK2.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00390000006115; -.
DR HOGENOM; CLU_126065_0_0_1; -.
DR InParanoid; Q08537; -.
DR OMA; PRRNMES; -.
DR OrthoDB; 1415812at2759; -.
DR TreeFam; TF337797; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000012750; Expressed in urethra and 28 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0120001; C:apical plasma membrane urothelial plaque; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IDA:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR CDD; cd09967; UP_II; 1.
DR InterPro; IPR009952; Uroplakin-2.
DR PANTHER; PTHR17573; PTHR17573; 1.
DR Pfam; PF07353; Uroplakin_II; 1.
DR PIRSF; PIRSF016439; Uroplakin_II; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cleavage on pair of basic residues;
KW Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..85
FT /id="PRO_0000022628"
FT CHAIN 86..185
FT /note="Uroplakin-2"
FT /id="PRO_0000022629"
FT TOPO_DOM 86..156
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 185 AA; 19619 MW; CD8BA31D57489173 CRC64;
MASPWPVWTL SWILILLAVL VPGAAADFNI SSLSGLLSPV MTESLLVALP PCHLTGGNAT
LTVRRANDSK VVRSSFVVPP CRGRRELVSV VDSGSGFTVT RLSAYQVTNL APGTKYYISY
LVTKGASTES SREIPMSTFP RRKAESIGLA MARTGGMVVI TVLLSVAMFL LVLGLIIALA
LGARK
